6H67: DNA-directed RNA polymerase I subunit RPA190

Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (CPD). Determined by electron microscopy at 3.6 Å resolution. Released 29 Aug 2018.

Method: Electron microscopy
Resolution: 3.6 Å
Organisms: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae
Chains: 17
Atoms: 33,803
Mol. weight: 625.81 kDa
Ligands: MG, ZN
Released: 29 Aug 2018

Explore 6H67 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6H67 contains 169 α-helices and 243 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 72 helices, 61 β-strands

Element	Residues	Length	Sheet
β-strand	10-17	8	1
α-helix	21-27	7
β-strand	31	1	2
β-strand	34	1	3
β-strand	38	1	4
α-helix	43	1
β-strand	44	1	4
α-helix	45	1
β-strand	48	1	3
β-strand	77-86	10	2
α-helix	91-99	9
β-strand	101	1	5
β-strand	108	1	5
α-helix	112-124	13
α-helix	136-138	3
α-helix	177-198	22
α-helix	210-226	17
β-strand	243-246	4	6
β-strand	250-253	4	6
α-helix	254-257	4
α-helix	258-267	10
α-helix	318-329	12
α-helix	332-338	7
α-helix	352-354	3
β-strand	356-362	7	2
α-helix	365-367	3
α-helix	381-402	22
α-helix	428-438	11
α-helix	452-454	3
α-helix	467-471	5
β-strand	474-476	3	7
β-strand	479-486	8	8
β-strand	494-497	4	8
α-helix	499-504	6
β-strand	506-510	5	9
α-helix	513-515	3
α-helix	517-525	9
β-strand	533-537	5	9
β-strand	543-545	3	9
α-helix	557-559	3
β-strand	576-580	5	9
α-helix	581	1
β-strand	586-590	5	8
β-strand	600-607	8	8
β-strand	614-616	3	8
α-helix	620-622	3
β-strand	632-636	5	8
α-helix	641-646	6
β-strand	652	1	8
α-helix	653-655	3
β-strand	658	1	10
β-strand	665	1	10
α-helix	671-680	10
α-helix	689-699	11
β-strand	719-721	3	11
β-strand	725	1	11
α-helix	728-738	11
β-strand	749-751	3	12
β-strand	769-772	4	12
β-strand	775-776	2	12
α-helix	783-786	4
α-helix	794-800	7
α-helix	803-823	21
β-strand	826-827	2	13
α-helix	831-833	3
β-strand	835	1	14
α-helix	839-847	9
α-helix	853-861	9
α-helix	873-884	12
α-helix	888-910	23
β-strand	916	1	14
α-helix	924-929	6
α-helix	937-940	4
α-helix	941-945	5
β-strand	948	1	15
β-strand	952	1	16
β-strand	955	1	16
α-helix	970	1
β-strand	982	1	15
β-strand	985	1	17
β-strand	989	1	17
α-helix	992-1025	34
β-strand	1031-1032	2	18
β-strand	1038-1039	2	18
β-strand	1045-1047	3	18
β-strand	1055	1	19
α-helix	1058-1060	3
α-helix	1066-1070	5
α-helix	1073-1080	8
α-helix	1082-1084	3
β-strand	1090	1	20
α-helix	1092-1107	16
α-helix	1123-1126	4
β-strand	1132	1	20
α-helix	1138-1150	13
α-helix	1152-1156	5
α-helix	1163-1176	14
β-strand	1178	1	19
α-helix	1185-1194	10
α-helix	1196-1199	4
α-helix	1219-1222	4
α-helix	1223-1228	6
β-strand	1238-1241	4	21
β-strand	1242	1	22
α-helix	1248-1256	9
β-strand	1262	1	23
α-helix	1264-1266	3
β-strand	1267-1272	6	24
β-strand	1289-1296	8	24
α-helix	1299-1302	4
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1333	12
α-helix	1442-1453	12
β-strand	1457-1462	6	24
β-strand	1469-1475	7	24
α-helix	1485-1495	11
β-strand	1497	1	23
β-strand	1507-1508	2	21
β-strand	1518-1521	4	21
α-helix	1530-1532	3
β-strand	1536	1	22
β-strand	1542-1543	2	21
α-helix	1547-1552	6
α-helix	1554-1570	17
α-helix	1579-1589	11
α-helix	1600-1602	3
α-helix	1609-1613	5
α-helix	1619-1626	8
β-strand	1632	1	1
α-helix	1637-1642	6
α-helix	1650-1653	4
β-strand	1654-1658	5	25

Chain B: 49 helices, 85 β-strands

Element	Residues	Length	Sheet
β-strand	14	1	26
α-helix	18-26	9
α-helix	38-40	3
α-helix	43-50	8
α-helix	61-68	8
β-strand	71-73	3	27
β-strand	95-105	11	27
α-helix	106-107	2
β-strand	108-109	2	28
β-strand	119-120	2	28
α-helix	123-129	7
β-strand	134	1	29
β-strand	136-144	9	27
β-strand	154-159	6	27
β-strand	162	1	29
α-helix	177-182	6
β-strand	194-196	3	30
β-strand	199-201	3	30
β-strand	202-203	2	31
β-strand	206	1	32
α-helix	209-210	2
β-strand	215-216	2	33
α-helix	220-225	6
β-strand	229	1	34
β-strand	234-239	6	33
β-strand	245-252	8	33
β-strand	253	1	34
β-strand	258-264	7	33
β-strand	267-272	6	33
α-helix	273-280	8
α-helix	285-293	9
α-helix	300-305	6
α-helix	307-313	7
α-helix	323-333	11
α-helix	335-338	4
α-helix	346-356	11
α-helix	360-362	3
α-helix	367-381	15
α-helix	390-392	3
α-helix	397-399	3
β-strand	403	1	32
α-helix	406-434	29
α-helix	443-449	7
α-helix	457-467	11
α-helix	475-477	3
β-strand	485-486	2	31
α-helix	493-498	6
α-helix	499-501	3
β-strand	502-503	2	35
β-strand	504	1	32
α-helix	520-521	2
α-helix	522-524	3
β-strand	528	1	36
β-strand	543-544	2	35
β-strand	545	1	36
α-helix	549	1
β-strand	550-551	2	37
α-helix	561-567	7
β-strand	584-588	5	38
β-strand	591-596	6	38
α-helix	598-614	17
β-strand	625	1	39
β-strand	628-629	2	38
β-strand	639-641	3	38
β-strand	643	1	39
β-strand	649-650	2	37
β-strand	652-655	4	40
β-strand	660-663	4	40
β-strand	674	1	40
β-strand	688-689	2	40
α-helix	707-709	3
β-strand	710	1	41
α-helix	712-718	7
β-strand	725	1	42
β-strand	740-744	5	43
β-strand	748	1	44
β-strand	752-753	2	45
α-helix	755-757	3
α-helix	762-764	3
β-strand	769-775	7	46
β-strand	776-777	2	13
β-strand	786-790	5	46
α-helix	791-794	4
β-strand	801-810	10	43
β-strand	823-825	3	47
α-helix	835-838	4
β-strand	840	1	48
α-helix	845	1
β-strand	846	1	48
α-helix	847	1
β-strand	852	1	49
β-strand	857-860	4	50
β-strand	861-863	3	47
β-strand	871-873	3	50
α-helix	874	1
β-strand	880	1	49
β-strand	881-888	8	43
β-strand	900-909	10	43
β-strand	916-918	3	46
β-strand	925-931	7	46
β-strand	938-939	2	51
β-strand	947-949	3	46
α-helix	951-953	3
β-strand	959	1	41
α-helix	961-975	15
α-helix	977	1
β-strand	978	1	26
β-strand	979-980	2	45
α-helix	992-1000	9
α-helix	1001-1003	3
β-strand	1010	1	46
β-strand	1013-1014	2	51
β-strand	1021	1	51
β-strand	1027-1035	9	46
β-strand	1036	1	42
β-strand	1045	1	8
β-strand	1052	1	52
β-strand	1059	1	52
α-helix	1060-1061	2
β-strand	1069-1071	3	7
α-helix	1074-1081	8
α-helix	1089-1092	4
β-strand	1098-1099	2	53
β-strand	1102-1104	3	54
β-strand	1115	1	55
β-strand	1122	1	56
β-strand	1126	1	55
β-strand	1133-1134	2	57
β-strand	1158-1159	2	57
β-strand	1167-1168	2	57
β-strand	1173-1175	3	54
β-strand	1178-1179	2	53
α-helix	1180-1189	10
β-strand	1195-1201	7	1

Chain C: 11 helices, 19 β-strands

Element	Residues	Length	Sheet
α-helix	33-38	6
β-strand	41	1	58
β-strand	46-47	2	59
β-strand	52-56	5	59
β-strand	57	1	58
α-helix	61-72	12
β-strand	76-88	13	60
α-helix	94-102	9
β-strand	106	1	61
β-strand	132-138	7	60
β-strand	141-142	2	62
α-helix	153-156	4
β-strand	157-158	2	62
β-strand	161-163	3	63
β-strand	168-170	3	60
α-helix	175-178	4
β-strand	186	1	61
β-strand	192-195	4	63
β-strand	202-212	11	60
α-helix	217-219	3
β-strand	225-235	11	59
α-helix	243-250	8
α-helix	252	1
β-strand	256-259	4	64
β-strand	264-267	4	64
α-helix	279-281	3
α-helix	283-286	4
β-strand	289-302	14	59
α-helix	310-329	20
β-strand	334	1	65

Chain D: 2 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	22-24	3	66
β-strand	29-30	2	66
α-helix	42-46	5
α-helix	83-89	7

Chain E: 9 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	5-26	22
α-helix	32-35	4
α-helix	39-45	7
β-strand	47	1	67
β-strand	53	1	67
β-strand	60-62	3	68
α-helix	66-71	6
β-strand	78-81	4	68
α-helix	90-103	14
β-strand	107-111	5	68
α-helix	118-121	4
β-strand	131-135	5	68
α-helix	144-146	3
β-strand	152-155	4	69
α-helix	158-167	10
β-strand	177-178	2	70
α-helix	185-188	4
β-strand	196-201	6	69
β-strand	207-211	5	69
β-strand	213-214	2	70

Chain F: 6 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	56-70	15
β-strand	84	1	71
α-helix	85-86	2
α-helix	87-102	16
α-helix	117-124	8
α-helix	125-127	3
β-strand	133-137	5	25
β-strand	143-147	5	25
α-helix	148-150	3
β-strand	152	1	71

Chain G: 5 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	38-49	12	66
α-helix	51-53	3
α-helix	57-61	5
α-helix	62-66	5
α-helix	67-69	3
β-strand	73	1	66
β-strand	80-89	10	66
β-strand	105-106	2	25
β-strand	107	1	66
α-helix	108	1
β-strand	114-125	12	66
β-strand	133	1	72
β-strand	136-137	2	73
β-strand	147-149	3	73
β-strand	153-155	3	73
β-strand	168-169	2	74
β-strand	216-217	2	74
β-strand	231	1	72
β-strand	236-237	2	73
β-strand	240	1	56
β-strand	244-245	2	73

Chain H: 1 helix, 9 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	11
β-strand	23-30	8	11
β-strand	37-43	7	11
β-strand	54-60	7	11
β-strand	95-98	4	11
β-strand	100-105	6	11
β-strand	111-119	9	11
β-strand	121-128	8	11
α-helix	140	1
β-strand	141-145	5	11

6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P10964 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P22138 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P07703 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P50106 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20435
DNA-directed RNA polymerase I subunit RPA43	G	protein	326	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P46669
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20436
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P32529
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P28000
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P40422

5 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>6H67_1 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 2 (B), FASTA

>6H67_2 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 3 (C), FASTA

>6H67_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (D), FASTA

>6H67_4 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 5 (E), FASTA

>6H67_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>6H67_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>6H67_7 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Sequence of entity 8 (H), FASTA

>6H67_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>6H67_9 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 10 (J), FASTA

>6H67_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>6H67_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 12 (L), FASTA

>6H67_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	6

Primary citation

Structural basis of RNA polymerase I stalling at UV light-induced DNA damage. Sanz-Murillo, M., Xu, J., Belogurov, G.A. et al. Proc Natl Acad Sci U S A (2018) 115:8972-8977. DOI 10.1073/pnas.1802626115 · PubMed

Other PDB entries of the same protein (UniProt P10964 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
9G1V 2.7 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site
4C2M 2.8 Å, Structure of RNA polymerase I at 2.8 A resolution
9G27 2.8 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, pre-translocation…
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
4C3I 3.0 Å, Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
6HLQ 3.18 Å, Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP
6HLR 3.18 Å, Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused)
9G2B 3.2 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, 12-subunit
6HLS 3.21 Å, Yeast apo RNA polymerase I*

Browse structure collections

About this viewer

MolViewer shows 6H67 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.