6HKO: Yeast RNA polymerase I elongation complex

Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP. Determined by electron microscopy at 3.42 Å resolution. Released 3 Apr 2019.

Method: Electron microscopy
Resolution: 3.42 Å
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Chains: 17
Atoms: 34,518
Mol. weight: 621.02 kDa
Ligands: MG, ZN, G2P
Released: 3 Apr 2019

Explore 6HKO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6HKO contains 188 α-helices and 236 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 80 helices, 64 β-strands

Element	Residues	Length	Sheet
β-strand	9	1	1
β-strand	11	1	2
β-strand	14-15	2	3
β-strand	18	1	4
α-helix	23-25	3
β-strand	38	1	5
α-helix	43	1
β-strand	44	1	5
α-helix	45	1
α-helix	52-54	3
β-strand	77-78	2	6
β-strand	85-86	2	7
α-helix	91-98	8
β-strand	101	1	8
β-strand	108	1	8
α-helix	112-126	15
α-helix	132-135	4
α-helix	175-198	24
α-helix	210-227	18
α-helix	241-242	2
β-strand	243-244	2	9
β-strand	252-253	2	9
α-helix	255-257	3
α-helix	264-266	3
β-strand	313-314	2	9
α-helix	317-330	14
α-helix	332-338	7
α-helix	348-350	3
α-helix	352-354	3
β-strand	356-357	2	7
β-strand	361-362	2	6
α-helix	363-364	2
α-helix	365-368	4
β-strand	371-373	3	10
β-strand	376-378	3	10
α-helix	381-399	19
α-helix	414-438	25
α-helix	452-454	3
α-helix	467-470	4
β-strand	474-475	2	11
β-strand	479-486	8	12
β-strand	494-497	4	12
α-helix	498	1
β-strand	506-510	5	13
α-helix	518-525	8
β-strand	533-537	5	13
β-strand	543-545	3	13
α-helix	551-559	9
α-helix	575	1
β-strand	576-580	5	13
α-helix	581	1
β-strand	586-590	5	12
α-helix	597-599	3
β-strand	600-607	8	12
β-strand	614-616	3	12
α-helix	621-624	4
β-strand	632-636	5	12
α-helix	641-647	7
β-strand	652	1	12
β-strand	658	1	14
β-strand	665	1	14
α-helix	672-680	9
β-strand	686-687	2	15
α-helix	689-699	11
α-helix	702-704	3
β-strand	719	1	16
β-strand	725	1	16
β-strand	726-727	2	15
α-helix	728-738	11
α-helix	741	1
α-helix	745-747	3
β-strand	749-752	4	17
β-strand	768-772	5	17
β-strand	775-778	4	17
α-helix	793-800	8
α-helix	803-816	14
β-strand	826	1	18
β-strand	835	1	19
α-helix	837-846	10
α-helix	849-851	3
α-helix	853-861	9
α-helix	864-865	2
α-helix	873-884	12
α-helix	886-911	26
β-strand	916	1	19
α-helix	924-930	7
α-helix	937-944	8
β-strand	948-949	2	20
α-helix	970	1
α-helix	977-979	3
β-strand	981-982	2	20
α-helix	992-1010	19
α-helix	1013-1027	15
β-strand	1031	1	21
β-strand	1039	1	21
β-strand	1045	1	21
α-helix	1050-1052	3
β-strand	1055	1	22
α-helix	1057-1059	3
α-helix	1066-1071	6
α-helix	1073-1080	8
α-helix	1082-1084	3
β-strand	1090	1	23
α-helix	1092-1107	16
β-strand	1132	1	23
α-helix	1140-1150	11
α-helix	1164-1176	13
β-strand	1178	1	22
α-helix	1179-1180	2
α-helix	1185-1197	13
α-helix	1219-1222	4
α-helix	1223-1227	5
β-strand	1238-1241	4	24
β-strand	1242	1	25
α-helix	1249-1252	4
α-helix	1255-1258	4
β-strand	1261-1262	2	26
β-strand	1267-1276	10	27
β-strand	1289-1296	8	27
α-helix	1299-1305	7
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1335	14
α-helix	1441-1453	13
β-strand	1461-1462	2	27
β-strand	1469-1475	7	27
α-helix	1481-1483	3
α-helix	1487-1495	9
β-strand	1497-1499	3	26
β-strand	1507-1508	2	24
β-strand	1518-1521	4	24
α-helix	1528-1530	3
β-strand	1536	1	25
β-strand	1543	1	24
α-helix	1548-1552	5
α-helix	1556-1567	12
α-helix	1581-1589	9
α-helix	1609-1615	7
α-helix	1623-1626	4
β-strand	1631-1632	2	3
α-helix	1639-1642	4
α-helix	1645-1647	3
α-helix	1650-1652	3
β-strand	1654-1660	7	28

Chain B: 55 helices, 80 β-strands

Element	Residues	Length	Sheet
α-helix	18-26	9
α-helix	33	1
α-helix	39-41	3
α-helix	43-51	9
α-helix	56-58	3
α-helix	59-68	10
β-strand	71	1	29
β-strand	96-104	9	29
α-helix	105-107	3
β-strand	108-110	3	30
α-helix	117	1
β-strand	118-120	3	30
α-helix	123-128	6
β-strand	134-144	11	29
β-strand	145	1	31
β-strand	150	1	31
β-strand	155-162	8	29
α-helix	163	1
β-strand	164	1	32
α-helix	177-182	6
β-strand	194-196	3	32
β-strand	199-203	5	32
α-helix	204	1
β-strand	205-209	5	33
α-helix	210	1
β-strand	215-218	4	34
α-helix	220-225	6
β-strand	229-239	11	34
β-strand	245-253	9	34
β-strand	258-263	6	34
β-strand	268-272	5	34
α-helix	273-280	8
α-helix	287-292	6
α-helix	300-316	17
α-helix	323-333	11
α-helix	346-356	11
α-helix	367-385	19
α-helix	397-399	3
β-strand	400-403	4	33
α-helix	407-433	27
α-helix	443-449	7
α-helix	457-467	11
β-strand	485-487	3	32
α-helix	493-498	6
β-strand	502-504	3	33
α-helix	507-510	4
α-helix	522-524	3
β-strand	528	1	35
β-strand	543-544	2	33
β-strand	545	1	35
α-helix	546	1
β-strand	550-551	2	36
α-helix	562-564	3
α-helix	570	1
β-strand	571-572	2	37
β-strand	584-588	5	37
β-strand	591-596	6	37
α-helix	598-613	16
β-strand	625-629	5	37
α-helix	637-638	2
β-strand	639-643	5	37
β-strand	649-650	2	36
β-strand	651-655	5	38
β-strand	660-664	5	38
α-helix	666-669	4
β-strand	674-675	2	38
β-strand	688-689	2	38
α-helix	699-702	4
α-helix	707-709	3
β-strand	710	1	39
α-helix	712-721	10
β-strand	725-726	2	40
β-strand	727	1	41
β-strand	740-744	5	41
β-strand	748	1	42
β-strand	753	1	43
α-helix	762-764	3
β-strand	768	1	42
β-strand	770-772	3	44
β-strand	773-775	3	45
β-strand	777	1	18
β-strand	787-790	4	45
α-helix	791-794	4
β-strand	801-810	10	41
β-strand	823-825	3	46
α-helix	834-837	4
β-strand	840	1	47
β-strand	846	1	47
α-helix	847	1
β-strand	851-852	2	41
β-strand	857-863	7	46
β-strand	868-873	6	46
β-strand	880-888	9	41
β-strand	900-909	10	41
β-strand	916-918	3	40
β-strand	925-926	2	40
β-strand	927-931	5	45
α-helix	933-935	3
β-strand	938-939	2	48
β-strand	947-949	3	45
α-helix	951-953	3
β-strand	959	1	39
α-helix	960-975	16
β-strand	980	1	43
α-helix	992-1003	12
β-strand	1010-1011	2	45
β-strand	1013-1014	2	48
α-helix	1020	1
β-strand	1021	1	48
α-helix	1022	1
β-strand	1026-1027	2	45
β-strand	1030-1032	3	44
β-strand	1034-1036	3	40
α-helix	1040-1042	3
β-strand	1045-1047	3	12
β-strand	1052	1	49
α-helix	1058	1
β-strand	1059	1	49
α-helix	1060	1
α-helix	1068-1069	2
β-strand	1070-1071	2	11
α-helix	1073-1076	4
α-helix	1077-1079	3
α-helix	1086-1089	4
α-helix	1090-1094	5
β-strand	1098-1104	7	1
β-strand	1114-1115	2	50
β-strand	1126-1127	2	50
β-strand	1158-1160	3	51
β-strand	1166-1168	3	51
β-strand	1173-1179	7	1
α-helix	1180-1190	11
β-strand	1194	1	4
β-strand	1197	1	3
β-strand	1200	1	2

Chain C: 11 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	33-39	7
β-strand	41-46	6	52
β-strand	51-57	7	52
α-helix	61-73	13
β-strand	77-88	12	53
α-helix	94-102	9
β-strand	106-107	2	54
β-strand	132-139	8	53
β-strand	141-142	2	55
α-helix	146-147	2
α-helix	153-156	4
β-strand	157-158	2	55
β-strand	161-162	2	56
α-helix	164-166	3
β-strand	168-170	3	53
α-helix	175-178	4
β-strand	185-186	2	54
β-strand	194-195	2	56
β-strand	201-211	11	53
α-helix	217-219	3
β-strand	222-235	14	52
α-helix	248-250	3
β-strand	256-258	3	57
β-strand	265-267	3	57
α-helix	279-281	3
β-strand	289-304	16	52
α-helix	310-330	21

Chain D: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	21-24	4	28
β-strand	29-30	2	28
α-helix	33-40	8
α-helix	45-48	4
α-helix	83-86	4
α-helix	90-93	4

Chain E: 10 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	5-26	22
β-strand	28	1	58
α-helix	32-35	4
α-helix	39-45	7
β-strand	47	1	59
β-strand	53	1	59
β-strand	61-62	2	60
β-strand	64	1	58
α-helix	66-71	6
β-strand	78-82	5	60
β-strand	87-88	2	61
α-helix	90-102	13
β-strand	107-112	6	60
β-strand	115-116	2	61
α-helix	120-122	3
β-strand	131-136	6	60
α-helix	144-146	3
β-strand	152-155	4	62
α-helix	159-168	10
α-helix	176	1
β-strand	177-178	2	62
α-helix	185-188	4
β-strand	195-202	8	62
β-strand	206-214	9	62

Chain F: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	56-71	16
β-strand	73	1	28
β-strand	84-85	2	63
α-helix	87-102	16
α-helix	105-107	3
α-helix	117-126	10
β-strand	132-137	6	28
β-strand	143-147	5	28
β-strand	152-153	2	63

Chain G: 4 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	38-49	12	28
α-helix	51-53	3
α-helix	57-61	5
α-helix	62-66	5
β-strand	73	1	28
β-strand	80-89	10	28
β-strand	103-107	5	28
α-helix	108	1
β-strand	114-125	12	28
β-strand	132-134	3	64
β-strand	136-140	5	65
β-strand	144-149	6	65
β-strand	153-158	6	65
β-strand	167-168	2	66
β-strand	217-218	2	66
β-strand	224	1	66
β-strand	230-232	3	64
β-strand	235-237	3	65
β-strand	244-246	3	65

Chain H: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	16
β-strand	23-30	8	16
β-strand	37-43	7	16
β-strand	54-60	7	16
α-helix	89-92	4
β-strand	95-108	14	16
β-strand	111-118	8	16
β-strand	121-127	7	16
α-helix	132-134	3
β-strand	139-145	7	16

6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P10964 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P22138 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P07703 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P50106 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20435
DNA-directed RNA polymerase I subunit RPA43	G	protein	326	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P46669
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20436
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P32529
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P28000
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P40422

5 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>6HKO_1 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 2 (B), FASTA

>6HKO_2 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 3 (C), FASTA

>6HKO_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (D), FASTA

>6HKO_4 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 5 (E), FASTA

>6HKO_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>6HKO_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>6HKO_7 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Sequence of entity 8 (H), FASTA

>6HKO_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>6HKO_9 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 10 (J), FASTA

>6HKO_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>6HKO_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 12 (L), FASTA

>6HKO_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	6
G2P	Phosphomethylphosphonic acid guanylate ester	C11 H18 N5 O13 P3	1

Primary citation

The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Tafur, L., Sadian, Y., Hanske, J. et al. Elife (2019) 8. DOI 10.7554/eLife.43204 · PubMed

Other PDB entries of the same protein (UniProt P10964 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
9G1V 2.7 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site
4C2M 2.8 Å, Structure of RNA polymerase I at 2.8 A resolution
9G27 2.8 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, pre-translocation…
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
4C3I 3.0 Å, Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
6HLQ 3.18 Å, Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP
6HLR 3.18 Å, Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused)
9G2B 3.2 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, 12-subunit
6HLS 3.21 Å, Yeast apo RNA polymerase I*

Browse structure collections

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