6HLR: Yeast RNA polymerase I elongation complex

Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused). Determined by electron microscopy at 3.18 Å resolution. Released 3 Apr 2019.

Method: Electron microscopy
Resolution: 3.18 Å
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Chains: 15
Atoms: 32,370
Mol. weight: 547.36 kDa
Ligands: G2P, ZN, MG
Released: 3 Apr 2019

Explore 6HLR in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6HLR contains 190 α-helices and 220 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 85 helices, 67 β-strands

Element	Residues	Length	Sheet
β-strand	11	1	1
β-strand	14-18	5	2
α-helix	23-26	4
β-strand	31	1	3
β-strand	38	1	4
α-helix	40-42	3
α-helix	43	1
β-strand	44	1	4
α-helix	45	1
β-strand	77-78	2	3
β-strand	85-86	2	5
α-helix	91-98	8
β-strand	101	1	6
β-strand	108	1	6
α-helix	112-126	15
α-helix	175-198	24
α-helix	210-227	18
β-strand	232	1	7
β-strand	239	1	7
β-strand	243-244	2	8
β-strand	252-253	2	8
α-helix	254-257	4
β-strand	313-314	2	8
α-helix	317-330	14
α-helix	332-338	7
α-helix	348-350	3
α-helix	352-354	3
β-strand	356-357	2	5
β-strand	361-362	2	3
α-helix	363-364	2
β-strand	371	1	9
β-strand	378	1	9
α-helix	381-399	19
α-helix	414-438	25
α-helix	452-454	3
α-helix	457-459	3
α-helix	467-470	4
β-strand	474-475	2	10
β-strand	479-486	8	11
β-strand	494-497	4	11
α-helix	499-504	6
β-strand	506-510	5	12
α-helix	511	1
α-helix	518-525	8
β-strand	533-537	5	12
β-strand	543-545	3	12
α-helix	551-559	9
α-helix	568-570	3
β-strand	576-580	5	12
α-helix	581	1
β-strand	586-590	5	11
α-helix	597-599	3
β-strand	600-607	8	11
β-strand	614-616	3	11
α-helix	618-620	3
α-helix	621-624	4
β-strand	632-636	5	11
α-helix	641-649	9
β-strand	652	1	11
α-helix	655-657	3
β-strand	658	1	13
β-strand	665	1	13
α-helix	672-680	9
β-strand	686-687	2	14
α-helix	689-697	9
α-helix	702-704	3
β-strand	719-721	3	15
β-strand	725	1	15
β-strand	726-727	2	14
α-helix	729-738	10
α-helix	741	1
α-helix	745-747	3
β-strand	749-752	4	16
β-strand	768-772	5	16
β-strand	775-778	4	16
α-helix	793-800	8
α-helix	803-819	17
β-strand	826-827	2	17
α-helix	830-833	4
β-strand	835	1	18
α-helix	837-846	10
α-helix	849-851	3
α-helix	853-861	9
α-helix	873-884	12
α-helix	886-911	26
β-strand	916	1	18
α-helix	924-930	7
α-helix	937-944	8
β-strand	948-949	2	19
α-helix	970	1
β-strand	981-982	2	19
β-strand	985	1	20
β-strand	989	1	20
α-helix	992-1010	19
α-helix	1017-1026	10
β-strand	1031	1	21
β-strand	1039	1	21
β-strand	1045	1	21
α-helix	1050-1052	3
β-strand	1055	1	22
α-helix	1057-1059	3
α-helix	1066-1071	6
α-helix	1073-1080	8
α-helix	1083-1085	3
β-strand	1090	1	23
α-helix	1092-1107	16
α-helix	1113-1115	3
α-helix	1123-1126	4
β-strand	1132	1	23
α-helix	1138-1150	13
α-helix	1163-1176	14
β-strand	1178	1	22
α-helix	1179-1180	2
α-helix	1185-1194	10
α-helix	1196-1199	4
α-helix	1219-1222	4
α-helix	1223-1228	6
β-strand	1238-1241	4	24
β-strand	1242	1	25
α-helix	1243	1
α-helix	1249-1252	4
α-helix	1255-1258	4
β-strand	1261-1262	2	26
α-helix	1263-1266	4
β-strand	1267-1276	10	27
β-strand	1288-1296	9	27
α-helix	1299-1305	7
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1334	13
α-helix	1441-1453	13
β-strand	1459-1462	4	27
β-strand	1469-1476	8	27
α-helix	1487-1493	7
β-strand	1497-1499	3	26
β-strand	1507-1508	2	24
α-helix	1513-1515	3
β-strand	1518-1521	4	24
α-helix	1528-1530	3
β-strand	1536	1	25
α-helix	1538-1540	3
β-strand	1542-1543	2	24
α-helix	1548-1553	6
α-helix	1555-1567	13
α-helix	1579-1589	11
α-helix	1609-1615	7
α-helix	1618-1626	9
β-strand	1631-1632	2	2
α-helix	1637-1643	7
α-helix	1645-1647	3
α-helix	1650-1653	4
β-strand	1654-1660	7	28

Chain B: 55 helices, 77 β-strands

Element	Residues	Length	Sheet
β-strand	14	1	29
α-helix	21-26	6
α-helix	33	1
α-helix	36-39	4
α-helix	43-49	7
α-helix	56-58	3
α-helix	59-68	10
β-strand	71	1	30
β-strand	96-104	9	30
α-helix	105-107	3
β-strand	108-109	2	31
α-helix	117-118	2
β-strand	119-120	2	31
α-helix	121-122	2
α-helix	123-128	6
β-strand	134-144	11	30
β-strand	151-152	2	30
β-strand	155-162	8	30
α-helix	177-182	6
β-strand	194-196	3	32
β-strand	199-203	5	32
α-helix	204	1
β-strand	205-209	5	33
α-helix	210	1
β-strand	215-218	4	34
α-helix	220-225	6
β-strand	229-239	11	34
β-strand	245-253	9	34
β-strand	258-263	6	34
β-strand	268-272	5	34
α-helix	273-280	8
α-helix	286-292	7
α-helix	300-316	17
α-helix	323-333	11
α-helix	346-356	11
α-helix	367-385	19
α-helix	390-393	4
α-helix	397-399	3
β-strand	400-403	4	33
α-helix	408-433	26
α-helix	443-449	7
α-helix	457-467	11
β-strand	485-487	3	32
α-helix	493-498	6
β-strand	502-504	3	33
α-helix	507-510	4
α-helix	522-524	3
β-strand	528	1	35
β-strand	543-544	2	33
β-strand	545	1	35
β-strand	550-551	2	36
α-helix	561-565	5
α-helix	566-568	3
α-helix	570	1
β-strand	571-572	2	37
β-strand	584-588	5	37
β-strand	591-596	6	37
α-helix	598-613	16
β-strand	625-629	5	37
α-helix	637-638	2
β-strand	639-643	5	37
β-strand	649-650	2	36
β-strand	651-655	5	38
β-strand	660-664	5	38
α-helix	666-669	4
β-strand	674-675	2	38
α-helix	681-682	2
β-strand	688-689	2	38
α-helix	699-703	5
α-helix	707-709	3
α-helix	712-722	11
β-strand	725	1	39
β-strand	741-744	4	40
β-strand	748	1	41
β-strand	752-753	2	42
α-helix	762-764	3
β-strand	769-772	4	43
β-strand	773-775	3	44
β-strand	776-777	2	17
β-strand	787-790	4	44
β-strand	801-810	10	40
α-helix	819-821	3
β-strand	823-825	3	45
α-helix	834-837	4
β-strand	840	1	46
β-strand	846	1	46
α-helix	847	1
β-strand	851-852	2	40
β-strand	857-863	7	45
β-strand	869-873	5	45
β-strand	880-888	9	40
β-strand	900-909	10	40
β-strand	916-918	3	47
β-strand	925-926	2	47
β-strand	927-931	5	44
α-helix	933-935	3
β-strand	938-939	2	48
β-strand	947-949	3	44
α-helix	951-953	3
α-helix	960-975	16
β-strand	978	1	29
β-strand	979-980	2	42
α-helix	992-1002	11
β-strand	1010-1011	2	44
β-strand	1013-1014	2	48
α-helix	1020	1
β-strand	1021	1	48
α-helix	1022	1
α-helix	1025	1
β-strand	1026-1027	2	44
β-strand	1030-1033	4	43
β-strand	1034-1035	2	47
β-strand	1036	1	39
β-strand	1045	1	11
β-strand	1052	1	49
α-helix	1058	1
β-strand	1059	1	49
α-helix	1060	1
β-strand	1070-1071	2	10
α-helix	1073-1081	9
α-helix	1086-1089	4
α-helix	1090-1094	5
β-strand	1098-1104	7	50
β-strand	1109	1	50
β-strand	1114-1115	2	51
β-strand	1126-1127	2	51
β-strand	1158-1160	3	52
β-strand	1166-1168	3	52
β-strand	1173-1179	7	50
α-helix	1180-1192	13
β-strand	1194-1197	4	2
β-strand	1200	1	1

Chain C: 15 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	33-39	7
β-strand	41-46	6	53
β-strand	51-57	7	53
α-helix	61-73	13
β-strand	79-88	10	54
α-helix	94-102	9
β-strand	106-107	2	55
α-helix	110-112	3
α-helix	122-125	4
β-strand	132-139	8	54
β-strand	141-142	2	56
α-helix	146-147	2
α-helix	153-156	4
β-strand	157-158	2	56
β-strand	161-163	3	57
α-helix	164-166	3
β-strand	168-170	3	54
α-helix	175-178	4
β-strand	185-186	2	55
β-strand	192-195	4	57
β-strand	201-209	9	54
α-helix	217-219	3
β-strand	222-235	14	53
α-helix	242-244	3
α-helix	246-249	4
β-strand	256-258	3	58
β-strand	265-267	3	58
α-helix	278-281	4
α-helix	283-285	3
β-strand	289-304	16	53
α-helix	310-330	21

Chain D: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	21-24	4	28
β-strand	29-30	2	28
α-helix	33-43	11
α-helix	45-48	4
α-helix	83-95	13

Chain E: 10 helices, 15 β-strands

Element	Residues	Length	Sheet
α-helix	5-26	22
β-strand	28	1	59
α-helix	32-35	4
α-helix	39-45	7
β-strand	47	1	60
β-strand	53	1	60
β-strand	61-62	2	61
β-strand	64	1	59
α-helix	66-71	6
β-strand	78-82	5	61
β-strand	87-88	2	62
α-helix	92-102	11
β-strand	107-112	6	61
β-strand	115-116	2	62
β-strand	131-132	2	61
β-strand	135-136	2	61
α-helix	144-146	3
β-strand	152-155	4	63
α-helix	158-167	10
α-helix	176	1
β-strand	177-178	2	63
α-helix	185-188	4
α-helix	190-191	2
β-strand	195-201	7	63
β-strand	207-214	8	63

Chain F: 5 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	57-71	15
β-strand	73	1	28
α-helix	76-78	3
β-strand	84-85	2	64
α-helix	87-101	15
α-helix	105-107	3
α-helix	117-126	10
β-strand	132-137	6	28
β-strand	143-147	5	28
β-strand	152-153	2	64

Chain G: 5 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	38-49	12	28
α-helix	51-53	3
α-helix	57-61	5
α-helix	62-66	5
β-strand	73	1	28
β-strand	80-89	10	28
α-helix	90-91	2
β-strand	103-107	5	28
α-helix	108	1
β-strand	114-125	12	28
β-strand	132-133	2	65
β-strand	136-139	4	65
β-strand	144-149	6	65
β-strand	153-158	6	65
β-strand	167-168	2	66
β-strand	217-218	2	66
β-strand	224	1	66
β-strand	231-237	7	65
β-strand	244-248	5	65

Chain H: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	15
β-strand	23-30	8	15
β-strand	37-43	7	15
β-strand	54-60	7	15
α-helix	89-92	4
β-strand	95-108	14	15
β-strand	111-118	8	15
β-strand	121-127	7	15
β-strand	139-145	7	15

4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P10964 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P22138 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P07703 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P50106 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20435
DNA-directed RNA polymerase I subunit RPA43	G	protein	326	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P46669
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20436
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P32529
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P28000
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P40422

3 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>6HLR_1 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 2 (B), FASTA

>6HLR_2 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 3 (C), FASTA

>6HLR_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (D), FASTA

>6HLR_4 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 5 (E), FASTA

>6HLR_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>6HLR_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>6HLR_7 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Sequence of entity 8 (H), FASTA

>6HLR_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>6HLR_9 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 10 (J), FASTA

>6HLR_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>6HLR_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 12 (L), FASTA

>6HLR_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
G2P	Phosphomethylphosphonic acid guanylate ester	C11 H18 N5 O13 P3	1
ZN	Zinc ion	Zn	6
MG	Magnesium ion	Mg	1

Primary citation

The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Tafur, L., Sadian, Y., Hanske, J. et al. Elife (2019) 8. DOI 10.7554/eLife.43204 · PubMed

Other PDB entries of the same protein (UniProt P10964 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
9G1V 2.7 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site
4C2M 2.8 Å, Structure of RNA polymerase I at 2.8 A resolution
9G27 2.8 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, pre-translocation…
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
4C3I 3.0 Å, Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
6HLQ 3.18 Å, Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP
9G2B 3.2 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, 12-subunit
6HLS 3.21 Å, Yeast apo RNA polymerase I*
4C3H 3.27 Å, Structure of 14-subunit RNA polymerase I at 3.27 A resolution, crystal form C2-93

Browse structure collections

About this viewer

MolViewer shows 6HLR directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.