6LQI: Mouse Piezo1 isoform Piezo1.1

Cryo-EM structure of the mouse Piezo1 isoform Piezo1.1. Determined by electron microscopy at 4.5 Å resolution. Released 4 Mar 2020.

Method
Electron microscopy
Resolution
4.5 Å
Organism
Mus musculus
Chains
3
Atoms
26,934
Mol. weight
868.77 kDa
Released
4 Mar 2020

Explore 6LQI in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6LQI contains 180 α-helices and 51 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 60 helices, 18 β-strands

ElementResiduesLengthSheet
α-helix578-5847
α-helix587-5959
α-helix605-62420
α-helix632-64918
α-helix693-70614
α-helix707-7115
α-helix712-7154
α-helix786-80318
α-helix805-82016
α-helix829-83911
α-helix846-86520
α-helix925-94925
α-helix974-98310
α-helix990-100516
α-helix1008-102215
α-helix1028-105225
α-helix1092-111019
α-helix1141-11444
α-helix1149-11557
α-helix1156-11605
α-helix1161-117414
α-helix1182-119918
α-helix1203-122321
α-helix1281-129818
α-helix1303-131412
α-helix1316-136449
α-helix1388-13903
α-helix1481-152040
α-helix1633-164412
α-helix1648-166114
α-helix1664-167613
α-helix1682-16843
α-helix1685-16895
α-helix1690-16945
α-helix1701-17022
α-helix1705-171915
α-helix1757-177620
α-helix1935-19417
α-helix1953-196917
α-helix1992-201524
α-helix2020-203617
α-helix2050-207526
α-helix2092-210110
α-helix2108-211811
α-helix2125-214925
α-helix2161-218020
α-helix2182-21876
β-strand219511
β-strand2201-220882
β-strand2215-222062
α-helix2221-22233
β-strand2224-222633
α-helix2227-22282
α-helix2229-22379
α-helix2243-22519
α-helix2254-22563
β-strand2257-226373
β-strand226514
α-helix2274-228613
β-strand2291-2300102
β-strand2311-231442
β-strand2317-232042
α-helix2325-23339
β-strand234815
β-strand2351-235443
β-strand235912
β-strand2361-236223
β-strand237515
β-strand2377-238594
α-helix2397-24015
β-strand2402-241094
β-strand2419-242683
β-strand242911
α-helix2443-245715
α-helix2468-24714
α-helix2477-249216
α-helix2495-251016
α-helix2513-25164
Chain B: 60 helices, 17 β-strands
ElementResiduesLengthSheet
α-helix578-5847
α-helix587-5959
α-helix605-62420
α-helix632-64918
α-helix693-70614
α-helix707-7115
α-helix712-7154
α-helix786-80318
α-helix805-82016
α-helix829-83911
α-helix846-86520
α-helix925-94925
α-helix974-98310
α-helix990-100516
α-helix1008-102215
α-helix1028-105225
α-helix1092-111019
α-helix1141-11444
α-helix1149-11557
α-helix1156-11605
α-helix1161-117414
α-helix1182-119918
α-helix1203-122321
α-helix1281-129818
α-helix1303-131412
α-helix1316-136449
α-helix1388-13903
α-helix1481-152040
α-helix1633-164412
α-helix1648-166114
α-helix1664-167613
α-helix1682-16843
α-helix1685-16895
α-helix1690-16945
α-helix1701-17022
α-helix1705-171915
α-helix1757-177620
α-helix1935-19417
α-helix1953-196917
α-helix1992-201524
α-helix2020-203617
α-helix2050-207526
α-helix2092-210110
α-helix2108-211811
α-helix2125-214925
α-helix2161-218020
α-helix2182-21876
β-strand219516
β-strand2201-220887
β-strand2215-222067
α-helix2221-22233
β-strand2224-222638
α-helix2227-22282
α-helix2229-22379
α-helix2243-22519
α-helix2254-22563
β-strand2257-226378
β-strand226519
α-helix2274-228613
β-strand2291-2300107
β-strand2311-231447
β-strand2317-232047
α-helix2325-23339
β-strand2348110
β-strand2351-235448
β-strand2361-236228
β-strand2375110
β-strand2377-238599
α-helix2397-24015
β-strand2402-241099
β-strand2419-242688
β-strand242916
α-helix2443-245715
α-helix2468-24714
α-helix2477-249216
α-helix2495-251016
α-helix2513-25164
Chain C: 60 helices, 16 β-strands
ElementResiduesLengthSheet
α-helix578-5847
α-helix587-5959
α-helix605-62420
α-helix632-64918
α-helix693-70614
α-helix707-7115
α-helix712-7154
α-helix786-80318
α-helix805-82016
α-helix829-83911
α-helix845-86521
α-helix925-94925
α-helix974-98310
α-helix990-100516
α-helix1008-102215
α-helix1028-105225
α-helix1092-111019
α-helix1141-11444
α-helix1149-11557
α-helix1156-11605
α-helix1161-117414
α-helix1182-119918
α-helix1203-122321
α-helix1281-129818
α-helix1303-131412
α-helix1316-136449
α-helix1388-13903
α-helix1481-152040
α-helix1633-164412
α-helix1648-166114
α-helix1664-167613
α-helix1682-16843
α-helix1685-16895
α-helix1690-16945
α-helix1701-17022
α-helix1705-171915
α-helix1757-177620
α-helix1935-19417
α-helix1953-196917
α-helix1992-201524
α-helix2020-203617
α-helix2050-207526
α-helix2092-210110
α-helix2108-211811
α-helix2125-214925
α-helix2161-218020
α-helix2182-21876
β-strand2195111
β-strand2201-2208812
β-strand2215-2220612
α-helix2221-22233
β-strand2224-2226313
α-helix2227-22282
α-helix2229-22379
α-helix2243-22519
α-helix2254-22563
β-strand2257-2263713
β-strand2265114
α-helix2274-228613
β-strand2291-23001012
β-strand2311-23201012
α-helix2325-23339
β-strand2348115
β-strand2351-2354413
β-strand2361-2362213
β-strand2375115
β-strand2377-2385914
α-helix2397-24015
β-strand2402-2410914
β-strand2419-2426813
β-strand2429111
α-helix2443-245715
α-helix2468-24714
α-helix2477-249216
α-helix2495-251016
α-helix2513-25164

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Piezo-type mechanosensitive ion channel component 1A, B, Cprotein2523Mus musculusE2JF22 (AlphaFold model)
Sequence of entity 1 (A, B, C), FASTA
>6LQI_1 Piezo-type mechanosensitive ion channel component 1 (chains A, B, C)
MEPHVLGAGLYWLLLPCTLLAASLLRFNALSLVYLLFLLLLPWLPGPSRHSIPGHTGRLL
RALLCLSLLFLVAHLAFQICLHTVPHLDQFLGQNGSLWVKVSQHIGVTRLDLKDIFNTTR
LVAPDLGVLLASSLCLGLCGRLTRKAGQSRRTQELQDDDDDDDDDDEDIDAAPAVGLKGA
PALATKRRLWLASRFRVTAHWLLMTSGRTLVIVLLALAGIAHPSAFSSIYLVVFLAICTW
WSCHFPLSPLGFNTLCVMVSCFGAGHLICLYCYQTPFIQDMLPPGNIWARLFGLKNFVDL
PNYSSPNALVLNTKHAWPIYVSPGILLLLYYTATSLLKLHKSCPSELRKETPREDEEHEL
ELDHLEPEPQARDATQGEMPMTTEPDLDNCTVHVLTSQSPVRQRPVRPRLAELKEMSPLH
GLGHLIMDQSYVCALIAMMVWSIMYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLY
GLTLCCLRYVWAMELPELPTTLGPVSLHQLGLEHTRYPCLDLGAMLLYLLTFWLLLRQFV
KEKLLKKQKVPAALLEVTVADTEPTQTQTLLRSLGELVTGIYVKYWIYVCAGMFIVVSFA
GRLVVYKIVYMFLFLLCLTLFQVYYTLWRKLLRVFWWLVVAYTMLVLIAVYTFQFQDFPT
YWRNLTGFTDEQLGDLGLEQFSVSELFSSILIPGFFLLACILQLHYFHRPFMQLTDLEHV
PPPGTRHPRWAHRQDAVSEAPLLEHQEEEEVFREDGQSMDGPHQATQVPEGTASKWGLVA
DRLLDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFAL
PYPRFRPMASCLSTVWTCIIIVCKMLYQLKIVNPHEYSSNCTEPFPNNTNLQPLEINQSL
LYRGPVDPANWFGVRKGYPNLGYIQNHLQILLLLVFEAVVYRRQEHYRRQHQQAPLPAQA
VCADGTRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAI
LTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPALCIDYPWRWSKAIPMNSALIKWL
YLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGINTDHLEPLRGEPNPI
PNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQ
KDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSNFCWVIQLFSLVCTVKGYYD
PKEMMTRDRDCLLPVEEAGIIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGF
ALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSKDPQDPSQE
PVIHSGDYFLFESDSEEEEEALPEDPRPAAQSAFQMAYQAWVTNAQTVLRQRRERARQER
AEQLASGGDLNPDVEPVDVPEDEMAGRSHMMQRVLSTMQFLWVLGQATVDGLTRWLRAFT
KHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLYVGEDEATLSGPVETRDGPSTASSG
LGAEEPLSSMTDDTSSPLSTGYNTRSGSEEIVTDAGDLQAGTSLHGSQELLANARTRMRT
ASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGYQCVAAHSELLCYFIIILNHMVTAS
AASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYVVLRRYE
NKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLWDHEEDRYPKDHCRSSVKD
REAKEEPEAKLESQSETGTGHPKEPVLAGTPRDHIQGKGSIRSKDVIQDPPEDLKPRHTR
HISIRFRRRKETPGPKGTAVMETEHEEGEGKETTERKRPRHTQEKSKFRERMKAAGRRLQ
SFCVSLAQSFYQPLQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAFGKHSAA
TDIASSLSDDQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGKLAFQVVLVVAIHIWMFFI
LPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQG
FRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKK
KIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQ
QPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQM
KQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQ
SVVIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLGVRIQLRREQVGTGASGEQAGTKAS
DFLEWWVIELQDCKADCNLLPMVIFSDKVSPPSLGFLAGYGIVGLYVSIVLVVGKFVRGF
FSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTR
ERE

Primary citation

A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel. Geng, J., Liu, W., Zhou, H. et al. Neuron (2020) 106:438. DOI 10.1016/j.neuron.2020.02.010 · PubMed

Other PDB entries of the same protein (UniProt E2JF22 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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