6TPS: DNA-directed RNA polymerase I subunit RPA190

early intermediate RNA Polymerase I Pre-initiation complex - eiPIC. Determined by electron microscopy at 3.54 Å resolution. Released 18 Mar 2020.

Method: Electron microscopy
Resolution: 3.54 Å
Organisms: Saccharomyces cerevisiae, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Synthetic construct
Chains: 22
Atoms: 50,070
Mol. weight: 880.41 kDa
Ligands: MG, ZN
Released: 18 Mar 2020

Explore 6TPS in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6TPS contains 265 α-helices and 299 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 77 helices, 67 β-strands

Element	Residues	Length	Sheet
β-strand	10-15	6	1
β-strand	18	1	2
α-helix	21-27	7
β-strand	38	1	3
β-strand	44	1	3
β-strand	77-80	4	4
α-helix	92-98	7
β-strand	101	1	5
β-strand	108	1	5
α-helix	113-124	12
α-helix	130-134	5
α-helix	178-195	18
α-helix	212-225	14
β-strand	232	1	6
β-strand	239	1	6
β-strand	242-245	4	7
β-strand	251-254	4	7
α-helix	258-266	9
β-strand	313-314	2	7
α-helix	315	1
α-helix	318-330	13
α-helix	332-338	7
α-helix	352-355	4
β-strand	359-362	4	4
α-helix	363-364	2
α-helix	365-367	3
β-strand	371-373	3	8
β-strand	376-378	3	8
α-helix	379-380	2
α-helix	381-405	25
α-helix	415-419	5
α-helix	423-438	16
α-helix	457-459	3
β-strand	474	1	9
β-strand	479-483	5	10
β-strand	484-486	3	11
β-strand	494-497	4	11
β-strand	506-510	5	12
α-helix	516-524	9
β-strand	533-537	5	12
β-strand	543-545	3	12
α-helix	551-558	8
α-helix	563-566	4
α-helix	575	1
β-strand	576-580	5	12
α-helix	581	1
β-strand	586-587	2	11
β-strand	588-590	3	10
α-helix	597-599	3
β-strand	602	1	13
β-strand	603-607	5	11
β-strand	614-616	3	11
α-helix	618-621	4
β-strand	632-636	5	10
α-helix	642-649	8
β-strand	652	1	13
β-strand	658	1	14
β-strand	665	1	14
α-helix	671-680	10
β-strand	686-687	2	15
α-helix	689-700	12
β-strand	721	1	16
β-strand	726-727	2	15
α-helix	731-739	9
β-strand	749-751	3	17
α-helix	757-759	3
β-strand	769-771	3	17
β-strand	776-778	3	17
α-helix	783-786	4
α-helix	793-800	8
α-helix	803-819	17
β-strand	826	1	18
α-helix	831-833	3
β-strand	835	1	19
α-helix	839-848	10
α-helix	853-862	10
α-helix	873-883	11
α-helix	886-911	26
β-strand	916	1	19
α-helix	924-930	7
α-helix	938-944	7
β-strand	948-949	2	20
β-strand	952	1	21
β-strand	955	1	21
α-helix	958-959	2
α-helix	970	1
β-strand	981-982	2	20
α-helix	992-1009	18
α-helix	1018-1026	9
β-strand	1031-1032	2	22
β-strand	1038-1039	2	22
β-strand	1045-1047	3	22
β-strand	1055	1	23
α-helix	1057-1059	3
α-helix	1066-1071	6
α-helix	1073-1080	8
α-helix	1082-1088	7
α-helix	1093-1107	15
α-helix	1113-1115	3
α-helix	1123-1126	4
α-helix	1138-1148	11
α-helix	1163-1176	14
β-strand	1178	1	23
α-helix	1179-1180	2
β-strand	1184	1	22
α-helix	1185-1190	6
α-helix	1196-1199	4
α-helix	1219-1222	4
α-helix	1223-1228	6
β-strand	1237-1240	4	24
β-strand	1242	1	25
α-helix	1248-1257	10
β-strand	1260-1262	3	26
α-helix	1263-1265	3
β-strand	1267-1275	9	27
β-strand	1288-1296	9	27
α-helix	1299-1306	8
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1334	13
α-helix	1335-1337	3
α-helix	1442-1452	11
β-strand	1457-1462	6	27
β-strand	1470-1476	7	27
α-helix	1486-1493	8
β-strand	1497-1500	4	26
β-strand	1507-1508	2	24
β-strand	1513	1	28
β-strand	1516	1	28
β-strand	1519-1522	4	24
α-helix	1527-1530	4
β-strand	1536	1	25
β-strand	1542-1543	2	24
α-helix	1549-1552	4
α-helix	1556-1572	17
α-helix	1579-1586	8
α-helix	1600-1603	4
α-helix	1609-1613	5
α-helix	1618-1628	11
α-helix	1630-1631	2
β-strand	1632	1	1
α-helix	1639-1643	5
α-helix	1650-1652	3
β-strand	1654-1661	8	29

Chain B: 54 helices, 83 β-strands

Element	Residues	Length	Sheet
α-helix	18-26	9
α-helix	36-38	3
α-helix	43-46	4
α-helix	59-66	8
β-strand	71-73	3	30
β-strand	95-104	10	30
β-strand	108-109	2	31
β-strand	119-120	2	31
α-helix	123-128	6
β-strand	134-136	3	32
β-strand	137-145	9	30
β-strand	152-155	4	30
β-strand	160-162	3	32
α-helix	177-182	6
β-strand	194-196	3	33
β-strand	199-203	5	33
β-strand	206-209	4	34
α-helix	210	1
β-strand	215-217	3	35
β-strand	229-239	11	35
β-strand	245-253	9	35
β-strand	258-264	7	35
β-strand	267-272	6	35
α-helix	273-280	8
α-helix	285-292	8
α-helix	303-313	11
α-helix	323-333	11
α-helix	348-356	9
α-helix	360-362	3
α-helix	369-385	17
α-helix	390-392	3
α-helix	397-399	3
β-strand	400-403	4	34
α-helix	406-432	27
α-helix	443-449	7
α-helix	458-467	10
β-strand	485-487	3	33
α-helix	493-497	5
β-strand	502	1	36
α-helix	507-509	3
β-strand	528	1	37
β-strand	544	1	36
β-strand	545	1	37
β-strand	552	1	38
α-helix	555-557	3
α-helix	561-566	6
α-helix	570	1
β-strand	571-572	2	39
β-strand	584-588	5	39
β-strand	592-596	5	39
α-helix	598-614	17
β-strand	625-629	5	39
α-helix	637-638	2
β-strand	639-643	5	39
β-strand	648	1	38
β-strand	651-655	5	40
β-strand	661-664	4	40
α-helix	667-669	3
β-strand	674-675	2	40
α-helix	681-682	2
β-strand	688-689	2	40
α-helix	693-696	4
α-helix	707-709	3
β-strand	710	1	41
α-helix	712-721	10
β-strand	725	1	42
β-strand	740-744	5	43
β-strand	748	1	44
β-strand	752-753	2	45
α-helix	756-759	4
β-strand	768	1	44
β-strand	770-775	6	46
β-strand	777	1	18
β-strand	786-790	5	46
α-helix	791-794	4
β-strand	801-810	10	43
β-strand	823-826	4	47
β-strand	840	1	48
β-strand	846	1	48
α-helix	847	1
β-strand	851-852	2	49
β-strand	854	1	50
β-strand	856	1	50
β-strand	857-859	3	51
β-strand	861-863	3	47
β-strand	869	1	47
β-strand	872-873	2	51
β-strand	880-881	2	49
β-strand	884-888	5	43
α-helix	889-890	2
β-strand	900-909	10	43
β-strand	916-918	3	46
β-strand	925-931	7	46
α-helix	933-935	3
β-strand	939	1	52
β-strand	947-949	3	46
α-helix	951-953	3
α-helix	954-957	4
β-strand	959	1	41
α-helix	961-975	15
β-strand	979-980	2	45
α-helix	992-1002	11
β-strand	1010-1011	2	46
β-strand	1013	1	52
β-strand	1014	1	53
α-helix	1020	1
β-strand	1021	1	53
α-helix	1022	1
β-strand	1026-1032	7	46
β-strand	1034-1035	2	46
β-strand	1036	1	42
α-helix	1040-1042	3
β-strand	1045-1047	3	10
α-helix	1051	1
β-strand	1052	1	54
α-helix	1053	1
α-helix	1058	1
β-strand	1059	1	54
α-helix	1060	1
β-strand	1071	1	9
α-helix	1074-1081	8
α-helix	1088-1089	2
α-helix	1090-1094	5
β-strand	1099-1104	6	55
β-strand	1113-1115	3	56
α-helix	1116	1
β-strand	1117	1	57
α-helix	1118	1
β-strand	1126-1128	3	56
β-strand	1133-1134	2	57
α-helix	1135-1138	4
β-strand	1158-1160	3	57
β-strand	1166-1168	3	57
β-strand	1173-1178	6	55
α-helix	1181-1191	11
β-strand	1194	1	2
β-strand	1197-1201	5	1

Chain C: 10 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	34-37	4
β-strand	41-47	7	58
β-strand	51-57	7	58
α-helix	61-73	13
β-strand	76-88	13	59
α-helix	94-102	9
β-strand	106	1	60
α-helix	115-117	3
β-strand	132-139	8	59
β-strand	141-142	2	61
α-helix	146-147	2
β-strand	157-158	2	61
β-strand	161-162	2	62
α-helix	167	1
β-strand	168-170	3	59
α-helix	175-178	4
β-strand	186	1	60
β-strand	194-195	2	62
β-strand	201-212	12	59
β-strand	222-226	5	58
β-strand	229-235	7	58
β-strand	240	1	63
α-helix	242-248	7
β-strand	256-258	3	64
β-strand	264	1	63
β-strand	265-267	3	64
α-helix	279-281	3
β-strand	289-304	16	58
α-helix	310-328	19
β-strand	334	1	65

Chain D: 2 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	21-24	4	66
β-strand	29-30	2	66
α-helix	33-44	12
α-helix	83-97	15

Chain E: 13 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	7-25	19
α-helix	32-34	3
α-helix	39-46	8
β-strand	47	1	67
β-strand	53	1	67
α-helix	55-57	3
β-strand	60-62	3	68
α-helix	66-71	6
β-strand	78-82	5	68
α-helix	90-101	12
β-strand	107-111	5	68
α-helix	120-126	7
β-strand	131-132	2	68
β-strand	135	1	68
α-helix	138-140	3
α-helix	144-146	3
β-strand	152-155	4	69
α-helix	156-157	2
α-helix	158-164	7
α-helix	172-174	3
β-strand	177	1	70
α-helix	183-188	6
β-strand	196-201	6	69
β-strand	207-212	6	69
β-strand	213	1	70

Chain F: 6 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	56-72	17
β-strand	73	1	29
α-helix	74-75	2
α-helix	76-78	3
β-strand	84	1	71
α-helix	87-102	16
α-helix	105-107	3
α-helix	117-125	9
β-strand	132-137	6	29
β-strand	143-147	5	29
β-strand	152	1	71

Chain G: 6 helices, 17 β-strands

Element	Residues	Length	Sheet
α-helix	18-20	3
β-strand	28	1	72
β-strand	35	1	72
β-strand	38-46	9	66
β-strand	47-49	3	29
α-helix	57-61	5
α-helix	62-66	5
α-helix	67-69	3
β-strand	73	1	66
β-strand	80-88	9	66
α-helix	89-91	3
β-strand	102-107	6	29
α-helix	108	1
β-strand	114-116	3	29
β-strand	119-125	7	66
β-strand	132-140	9	73
β-strand	144-149	6	73
β-strand	153-158	6	73
β-strand	167-169	3	74
β-strand	216-218	3	74
β-strand	224	1	74
β-strand	229-237	9	73
β-strand	244-248	5	73

Chain H: 2 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	16
β-strand	10-16	7	16
β-strand	23-30	8	16
β-strand	37-43	7	16
α-helix	49-50	2
β-strand	54-60	7	16
α-helix	89-91	3
β-strand	95-106	12	16
β-strand	111-118	8	16
β-strand	121-128	8	16
β-strand	139-145	7	16

10 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae	P10964 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae	P22138 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae	P07703 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae	P50106 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae	P20435
DNA-directed RNA polymerase I subunit RPA43	G	protein	326	Saccharomyces cerevisiae	P46669
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae	P20436
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	Saccharomyces cerevisiae	P32529
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	Saccharomyces cerevisiae	P28000
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	Saccharomyces cerevisiae	P40422

10 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>6TPS_1 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 2 (B), FASTA

>6TPS_2 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 3 (C), FASTA

>6TPS_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (D), FASTA

>6TPS_4 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 5 (E), FASTA

>6TPS_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>6TPS_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>6TPS_7 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Sequence of entity 8 (H), FASTA

>6TPS_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>6TPS_9 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 10 (J), FASTA

>6TPS_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>6TPS_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 12 (L), FASTA

>6TPS_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	7

Primary citation

Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting. Pilsl, M., Engel, C. Nat Commun (2020) 11:1206-1206. DOI 10.1038/s41467-020-15052-y · PubMed

Other PDB entries of the same protein (UniProt P10964 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
9G1V 2.7 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site
4C2M 2.8 Å, Structure of RNA polymerase I at 2.8 A resolution
9G27 2.8 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, pre-translocation…
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
4C3I 3.0 Å, Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
6HLQ 3.18 Å, Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP
6HLR 3.18 Å, Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused)
9G2B 3.2 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, 12-subunit
6HLS 3.21 Å, Yeast apo RNA polymerase I*

Browse structure collections

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