6U0M: S. cerevisiae replicative helicase CMG
Structure of the S. cerevisiae replicative helicase CMG in complex with a forked DNA. Determined by electron microscopy at 3.9 Å resolution. Released 25 Mar 2020.
- Method
- Electron microscopy
- Resolution
- 3.9 Å
- Organism
- Saccharomyces cerevisiae
- Chains
- 13
- Atoms
- 41,146
- Mol. weight
- 661.1 kDa
- Ligands
- ATP
- Released
- 25 Mar 2020
Explore 6U0M in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6U0M contains 208 α-helices and 184 β-strands across 11 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 2: 28 helices, 23 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 203-216 | 14 | |
| α-helix | 227-236 | 10 | |
| α-helix | 246-251 | 6 | |
| α-helix | 257-259 | 3 | |
| α-helix | 266-280 | 15 | |
| α-helix | 286-288 | 3 | |
| α-helix | 311-313 | 3 | |
| β-strand | 317-324 | 8 | 15 |
| β-strand | 331-333 | 3 | 16 |
| β-strand | 338 | 1 | 17 |
| β-strand | 340 | 1 | 18 |
| β-strand | 350 | 1 | 17 |
| α-helix | 371-373 | 3 | |
| β-strand | 374 | 1 | 18 |
| β-strand | 383-385 | 3 | 16 |
| β-strand | 390-391 | 2 | 15 |
| β-strand | 405 | 1 | 15 |
| β-strand | 408-409 | 2 | 19 |
| α-helix | 412-414 | 3 | |
| β-strand | 423-429 | 7 | 15 |
| β-strand | 431 | 1 | 20 |
| α-helix | 442 | 1 | |
| β-strand | 446 | 1 | 21 |
| β-strand | 450 | 1 | 20 |
| β-strand | 451-452 | 2 | 19 |
| β-strand | 453-457 | 5 | 15 |
| α-helix | 494-497 | 4 | |
| α-helix | 509-520 | 12 | |
| β-strand | 541-542 | 2 | 22 |
| α-helix | 549-559 | 11 | |
| β-strand | 565-567 | 3 | 23 |
| β-strand | 579-581 | 3 | 24 |
| α-helix | 582-583 | 2 | |
| β-strand | 590-592 | 3 | 24 |
| α-helix | 595-598 | 4 | |
| β-strand | 603-605 | 3 | 23 |
| α-helix | 610-616 | 7 | |
| β-strand | 649-650 | 2 | 22 |
| α-helix | 663-666 | 4 | |
| α-helix | 671-674 | 4 | |
| β-strand | 681-682 | 2 | 22 |
| α-helix | 690-702 | 13 | |
| α-helix | 738-750 | 13 | |
| α-helix | 764-766 | 3 | |
| α-helix | 767-770 | 4 | |
| α-helix | 784-786 | 3 | |
| α-helix | 787-796 | 10 | |
| α-helix | 807-822 | 16 | |
| α-helix | 832-838 | 7 | |
| α-helix | 842-846 | 5 | |
| α-helix | 857-860 | 4 | |
Chain 3: 23 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 22-30 | 9 | |
| α-helix | 39-47 | 9 | |
| α-helix | 49-52 | 4 | |
| β-strand | 99 | 1 | 25 |
| α-helix | 100-104 | 5 | |
| α-helix | 109-112 | 4 | |
| α-helix | 113-115 | 3 | |
| α-helix | 122-134 | 13 | |
| β-strand | 158 | 1 | 25 |
| β-strand | 179-186 | 8 | 26 |
| β-strand | 193-199 | 7 | 27 |
| β-strand | 201-203 | 3 | 28 |
| α-helix | 205-207 | 3 | |
| β-strand | 208-209 | 2 | 28 |
| β-strand | 212-213 | 2 | 27 |
| α-helix | 224-226 | 3 | |
| β-strand | 241-243 | 3 | 28 |
| α-helix | 245-247 | 3 | |
| β-strand | 249-253 | 5 | 27 |
| β-strand | 254-258 | 5 | 26 |
| β-strand | 274-278 | 5 | 26 |
| α-helix | 280-282 | 3 | |
| β-strand | 291-301 | 11 | 26 |
| β-strand | 318-328 | 11 | 26 |
| α-helix | 344-352 | 9 | |
| α-helix | 359-365 | 7 | |
| α-helix | 375-386 | 12 | |
| α-helix | 392-393 | 2 | |
| β-strand | 405 | 1 | 29 |
| β-strand | 406-409 | 4 | 30 |
| α-helix | 448-450 | 3 | |
| α-helix | 480-491 | 12 | |
| β-strand | 494-495 | 2 | 31 |
| β-strand | 506-507 | 2 | 31 |
| β-strand | 513 | 1 | 29 |
| β-strand | 516 | 1 | 30 |
| α-helix | 537-542 | 6 | |
| β-strand | 546-549 | 4 | 30 |
| α-helix | 557-564 | 8 | |
| α-helix | 653-660 | 8 | |
| α-helix | 675-687 | 13 | |
| α-helix | 701-716 | 16 | |
| α-helix | 725-737 | 13 | |
Chain 4: 23 helices, 23 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 189-199 | 11 | |
| α-helix | 225-234 | 10 | |
| β-strand | 240-243 | 4 | 32 |
| α-helix | 255-261 | 7 | |
| α-helix | 267-284 | 18 | |
| α-helix | 291-293 | 3 | |
| α-helix | 300-301 | 2 | |
| β-strand | 302-305 | 4 | 32 |
| β-strand | 326-335 | 10 | 33 |
| β-strand | 342 | 1 | 34 |
| β-strand | 348-349 | 2 | 35 |
| β-strand | 382-383 | 2 | 35 |
| β-strand | 391 | 1 | 34 |
| β-strand | 395 | 1 | 36 |
| β-strand | 397-400 | 4 | 33 |
| α-helix | 411-412 | 2 | |
| β-strand | 414-416 | 3 | 33 |
| β-strand | 419 | 1 | 36 |
| β-strand | 432-442 | 11 | 33 |
| β-strand | 458-467 | 10 | 33 |
| α-helix | 504-514 | 11 | |
| α-helix | 518-525 | 8 | |
| α-helix | 536-544 | 9 | |
| β-strand | 564-566 | 3 | 37 |
| α-helix | 574-584 | 11 | |
| α-helix | 617-619 | 3 | |
| α-helix | 620-623 | 4 | |
| β-strand | 629-632 | 4 | 37 |
| α-helix | 645-650 | 6 | |
| β-strand | 653-657 | 5 | 38 |
| β-strand | 662-666 | 5 | 38 |
| β-strand | 671-674 | 4 | 37 |
| α-helix | 696-699 | 4 | |
| β-strand | 706 | 1 | 37 |
| α-helix | 717-725 | 9 | |
| α-helix | 746-757 | 12 | |
| β-strand | 761 | 1 | 39 |
| α-helix | 764-777 | 14 | |
| α-helix | 796-811 | 16 | |
| β-strand | 816 | 1 | 39 |
| α-helix | 822-832 | 11 | |
| α-helix | 856-875 | 20 | |
| α-helix | 883-893 | 11 | |
| α-helix | 905-911 | 7 | |
| β-strand | 917-918 | 2 | 40 |
| β-strand | 924-925 | 2 | 40 |
Chain 5: 25 helices, 32 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 25-32 | 8 | |
| α-helix | 47-50 | 4 | |
| α-helix | 51-53 | 3 | |
| β-strand | 60 | 1 | 41 |
| α-helix | 65-68 | 4 | |
| α-helix | 73-80 | 8 | |
| α-helix | 86-100 | 15 | |
| β-strand | 136 | 1 | 41 |
| β-strand | 160-168 | 9 | 42 |
| β-strand | 175-178 | 4 | 43 |
| β-strand | 181-183 | 3 | 44 |
| β-strand | 189-190 | 2 | 44 |
| β-strand | 193 | 1 | 43 |
| β-strand | 241-243 | 3 | 44 |
| β-strand | 249-251 | 3 | 43 |
| β-strand | 256 | 1 | 45 |
| β-strand | 257-260 | 4 | 42 |
| α-helix | 269-271 | 3 | |
| β-strand | 273 | 1 | 42 |
| β-strand | 276-277 | 2 | 45 |
| α-helix | 280-282 | 3 | |
| β-strand | 291-296 | 6 | 42 |
| β-strand | 300-301 | 2 | 46 |
| β-strand | 323 | 1 | 16 |
| β-strand | 325-326 | 2 | 46 |
| β-strand | 328-329 | 2 | 45 |
| β-strand | 330-332 | 3 | 42 |
| α-helix | 352-361 | 10 | |
| α-helix | 366-373 | 8 | |
| α-helix | 382-393 | 12 | |
| β-strand | 398 | 1 | 47 |
| β-strand | 406 | 1 | 47 |
| β-strand | 412-413 | 2 | 48 |
| β-strand | 414-415 | 2 | 49 |
| α-helix | 426-432 | 7 | |
| β-strand | 436-438 | 3 | 50 |
| α-helix | 447-450 | 4 | |
| β-strand | 452-456 | 5 | 51 |
| β-strand | 461-466 | 6 | 51 |
| β-strand | 476-478 | 3 | 50 |
| β-strand | 479-480 | 2 | 49 |
| α-helix | 489-493 | 5 | |
| β-strand | 501-503 | 3 | 52 |
| β-strand | 512-514 | 3 | 52 |
| β-strand | 521-523 | 3 | 49 |
| α-helix | 530-533 | 4 | |
| β-strand | 552-553 | 2 | 48 |
| α-helix | 564-576 | 13 | |
| α-helix | 581-584 | 4 | |
| α-helix | 596-607 | 12 | |
| α-helix | 616-618 | 3 | |
| α-helix | 619-634 | 16 | |
| α-helix | 637-639 | 3 | |
| α-helix | 653-667 | 15 | |
| α-helix | 674-684 | 11 | |
| α-helix | 685-687 | 3 | |
| α-helix | 689-691 | 3 | |
Chain 6: 22 helices, 26 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 104-120 | 17 | |
| α-helix | 135-146 | 12 | |
| β-strand | 153-154 | 2 | 53 |
| α-helix | 155-159 | 5 | |
| α-helix | 167-170 | 4 | |
| α-helix | 174-192 | 19 | |
| β-strand | 267-268 | 2 | 53 |
| β-strand | 274 | 1 | 54 |
| β-strand | 290 | 1 | 54 |
| β-strand | 293-295 | 3 | 55 |
| β-strand | 301-303 | 3 | 21 |
| β-strand | 306 | 1 | 56 |
| β-strand | 321 | 1 | 56 |
| β-strand | 354-356 | 3 | 21 |
| β-strand | 357-362 | 6 | 55 |
| α-helix | 365-367 | 3 | |
| β-strand | 378-381 | 4 | 55 |
| β-strand | 394 | 1 | 55 |
| β-strand | 396 | 1 | 57 |
| β-strand | 400-404 | 5 | 58 |
| α-helix | 434-436 | 3 | |
| β-strand | 451-455 | 5 | 58 |
| β-strand | 460 | 1 | 57 |
| α-helix | 512-519 | 8 | |
| α-helix | 525-530 | 6 | |
| α-helix | 541-551 | 11 | |
| β-strand | 571-572 | 2 | 59 |
| α-helix | 581-591 | 11 | |
| β-strand | 597 | 1 | 59 |
| α-helix | 612-614 | 3 | |
| α-helix | 629-631 | 3 | |
| β-strand | 634 | 1 | 60 |
| β-strand | 637-639 | 3 | 59 |
| α-helix | 648-657 | 10 | |
| β-strand | 661-663 | 3 | 61 |
| β-strand | 670-672 | 3 | 61 |
| β-strand | 676 | 1 | 60 |
| β-strand | 679-681 | 3 | 59 |
| α-helix | 695-698 | 4 | |
| α-helix | 704-708 | 5 | |
| α-helix | 723-735 | 13 | |
| α-helix | 748-758 | 11 | |
| β-strand | 764-765 | 2 | 62 |
| α-helix | 770-784 | 15 | |
| α-helix | 799-805 | 7 | |
| α-helix | 807-813 | 7 | |
| β-strand | 818-819 | 2 | 62 |
| α-helix | 825-838 | 14 | |
Chain 7: 28 helices, 23 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 15-22 | 8 | |
| α-helix | 62-71 | 10 | |
| β-strand | 80-81 | 2 | 63 |
| α-helix | 83-90 | 8 | |
| α-helix | 102-108 | 7 | |
| α-helix | 110-112 | 3 | |
| α-helix | 115-121 | 7 | |
| α-helix | 122-124 | 3 | |
| α-helix | 140-151 | 12 | |
| α-helix | 152-154 | 3 | |
| α-helix | 191-193 | 3 | |
| β-strand | 204-205 | 2 | 63 |
| β-strand | 225 | 1 | 64 |
| α-helix | 227-229 | 3 | |
| β-strand | 238-246 | 9 | 64 |
| β-strand | 254-255 | 2 | 65 |
| β-strand | 260-261 | 2 | 66 |
| β-strand | 269 | 1 | 66 |
| α-helix | 296-298 | 3 | |
| β-strand | 299-300 | 2 | 66 |
| β-strand | 307-308 | 2 | 65 |
| β-strand | 313-316 | 4 | 64 |
| α-helix | 327-328 | 2 | |
| β-strand | 331-334 | 4 | 64 |
| β-strand | 348-356 | 9 | 64 |
| β-strand | 371 | 1 | 27 |
| β-strand | 375-381 | 7 | 64 |
| α-helix | 398-407 | 10 | |
| α-helix | 413-417 | 5 | |
| α-helix | 430-437 | 8 | |
| β-strand | 456-459 | 4 | 67 |
| α-helix | 467-474 | 8 | |
| β-strand | 480-482 | 3 | 67 |
| β-strand | 496-497 | 2 | 68 |
| β-strand | 508-509 | 2 | 68 |
| β-strand | 520-522 | 3 | 67 |
| α-helix | 530-536 | 7 | |
| α-helix | 538-541 | 4 | |
| β-strand | 546-547 | 2 | 69 |
| β-strand | 556-557 | 2 | 69 |
| β-strand | 562-567 | 6 | 67 |
| α-helix | 587-591 | 5 | |
| β-strand | 597 | 1 | 67 |
| α-helix | 606-617 | 12 | |
| α-helix | 618-620 | 3 | |
| α-helix | 635-646 | 12 | |
| α-helix | 650-652 | 3 | |
| α-helix | 660-666 | 7 | |
| α-helix | 671-674 | 4 | |
| α-helix | 686-702 | 17 | |
| α-helix | 710-721 | 12 | |
Chain A: 8 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-23 | 20 | |
| α-helix | 34-57 | 24 | |
| α-helix | 66-94 | 29 | |
| α-helix | 125-127 | 3 | |
| α-helix | 128-144 | 17 | |
| α-helix | 157-158 | 2 | |
| β-strand | 162-165 | 4 | 1 |
| β-strand | 167 | 1 | 2 |
| β-strand | 188-192 | 5 | 1 |
| α-helix | 193-195 | 3 | |
| α-helix | 197-200 | 4 | |
| β-strand | 205 | 1 | 2 |
Chain B: 7 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 16-20 | 5 | |
| β-strand | 24-26 | 3 | 3 |
| β-strand | 27-29 | 3 | 4 |
| α-helix | 63-64 | 2 | |
| β-strand | 70-72 | 3 | 3 |
| α-helix | 73-81 | 9 | |
| β-strand | 85-87 | 3 | 4 |
| α-helix | 101-104 | 4 | |
| α-helix | 119-125 | 7 | |
| α-helix | 143-160 | 18 | |
| β-strand | 170 | 1 | 5 |
| α-helix | 175-197 | 23 | |
3 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| DNA replication complex GINS protein PSF1 | A | protein | 208 | Saccharomyces cerevisiae | Q12488 (AlphaFold model) |
| DNA replication complex GINS protein PSF2 | B | protein | 198 | Saccharomyces cerevisiae | P40359 (AlphaFold model) |
| DNA replication complex GINS protein PSF3 | C | protein | 191 | Saccharomyces cerevisiae | Q12146 (AlphaFold model) |
| DNA replication complex GINS protein SLD5 | D | protein | 291 | Saccharomyces cerevisiae | Q03406 (AlphaFold model) |
| Cell division control protein 45 | E | protein | 646 | Saccharomyces cerevisiae | Q08032 |
| DNA replication licensing factor MCM2 | 2 | protein | 664 | Saccharomyces cerevisiae | P29469 |
| DNA replication licensing factor MCM3 | 3 | protein | 722 | Saccharomyces cerevisiae | P24279 |
| DNA replication licensing factor MCM4 | 4 | protein | 753 | Saccharomyces cerevisiae | P30665 |
| Minichromosome maintenance protein 5 | 5 | protein | 670 | Saccharomyces cerevisiae | P29496 |
| DNA replication licensing factor MCM6 | 6 | protein | 667 | Saccharomyces cerevisiae | P53091 |
| DNA replication licensing factor MCM7 | 7 | protein | 729 | Saccharomyces cerevisiae | P38132 |
| DNA (26-mer) | F | DNA | 23 | Saccharomyces cerevisiae | |
1 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>6U0M_1 DNA replication complex GINS protein PSF1 (chains A)
MYGDLGNKLVLEAKRTKQLYARSNQDVNLPMYHEDIIRNILKEVSNLRKNTEYLKEQQQL
GMLDDKVAKCQYFVTLLCMERNKRCLLAYQRLRTDILDSMAWNNNGLDLMSSITFSQQDT
NNLSHQEQEYLKEYCDLITDLKSGDLVDIDLSGSLVPPSDVFIDVRVLKDAGEIQTEYGV
FNLIKDSQFFVRQSDVERLIQQGYLQKI
Sequence of entity 2 (B), FASTA
>6U0M_2 DNA replication complex GINS protein PSF2 (chains B)
LPAHLQQTFSPEEIQFIVENEPIKIFPRITTRQKIRGDDRGTGNHTRWQLITTDDKALNN
MVAMRSTEVVLWIALLLKQQSKCSIVAPQWLTTKELDRKIQYEKTHPDRFSELPWNWLVL
ARILFNKAKDDFHDPIHELRGKIQDLREIRQIKVLKGLKYLNESHLQLDNLSLLEINELR
PFITEIMDKLREIHTASL
Sequence of entity 3 (C), FASTA
>6U0M_3 DNA replication complex GINS protein PSF3 (chains C)
YYDIDDVLADGTEFPCKFQYDIPGLGYLENNPGRPITKNTKLSLPLWLARILAIVGGDEA
LVDEEPVPFVELLPPDMFSTKVMNAIKTDPVALDLHSINSHFFSLAIKWIMLFSEKELAN
VVSELLLQRAQELNHHASSLSIDLNADSTGKNSANTNIATSTFLLKLEEMEKEIYKKSHE
SYKDTKRWMFK
Sequence of entity 4 (D), FASTA
>6U0M_4 DNA replication complex GINS protein SLD5 (chains D)
INIDDILAELDKETTAVDSTKITQGSSSTTHRDANTIVGSSLDLNDKTQIYVSPQQDFSD
LMKSWKNERCSPELLPYPHQLMKRLLNRISMQSQLIENISMGFLDMQNASNANPPMPNES
KLPLLCMETELERLKFVIRSYIRCRLSKIDKFSLYLRQLNEDENSLISLTDLLSKDEIKY
HDTHSLIWLKLVNDSILKYMPEELQAINDTEGSVNMIDEPDWNKFVFIHVNGPPDGKWNE
DPLLQENEFGKPCYTVTIPDLKEEVELTIGSIYVMRYEVIRDLLRDDKVAL
Sequence of entity 5 (E), FASTA
>6U0M_5 Cell division control protein 45 (chains E)
ISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVPIFGY
SELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDIYVLD
AHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYKLLELDEESGDDELSGDENDNNGG
DDEATDADEVTDEDEEDEDETISNKRGNSSIGPNDLSKRKQRKKQIHEYEGVLEEYYSQG
TTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAYAQVYNRLYPLLQDEVKRLTP
SSRNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNENGKKRLHKMFA
RMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTLGYRGSISASEF
VEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRWVSNFWLSWDAL
DDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDGPDLDLYRNPLT
LLRLGNWLIECCAESEDKQLLPMVLASIDENTDTYLVAGLTPRYPRGLDTIHTKKPILNN
FSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLL
Sequence of entity 6 (2), FASTA
>6U0M_6 DNA replication licensing factor MCM2 (chains 2)
PNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFL
AKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRV
TGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIRISFCTNCKSKGPFRVNGEKT
VYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNA
KNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEEEREFRKISRDRGIIDKIISS
MAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTA
HRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSI
HEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDIL
CVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELKNNGESAIEQGEDEINEQLNA
RQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESIST
GSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVRRQLRRS
FAIY
Sequence of entity 7 (3), FASTA
>6U0M_7 DNA replication licensing factor MCM3 (chains 3)
PDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDDADERDLLGDDDGDD
LEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSM
DDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKL
IRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRI
TVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIG
FKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDH
IKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRG
SSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVT
IAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEI
RDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINPEEHSNSGAGVENEGED
DEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYVQYAKERVIPQLTQEAI
NVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFA
LL
Sequence of entity 8 (4), FASTA
>6U0M_8 DNA replication licensing factor MCM4 (chains 4)
LRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMREL
GTSNLNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEI
ETKFYKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTM
AVEIDRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSIS
LCVYDELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDV
DTSTIEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDV
KKGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGS
SAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISI
AKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKN
DRELAKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVG
MRKMGDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDY
ATDPKTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQD
RVESSDIQEALSRLQQEDKVIVLGEGVRRSVRL
Sequence of entity 9 (5), FASTA
>6U0M_9 Minichromosome maintenance protein 5 (chains 5)
NTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLIGYNEDIYKKLSDEP
SDIIPLFETAITQVAKRISILSRAQSANNNDKDPENTSMDTDSLLLNSLPTFQLILNSNA
NQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFNSITGN
TVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKLQEIPE
LVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGAGSGRSGGGNGGSGVAI
RTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNED
IKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKG
SSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTIS
IAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEE
RDISIANHVINIHTGNANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLS
SNFVTIRKQLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRL
FQASTMDAAS
Sequence of entity 10 (6), FASTA
>6U0M_10 DNA replication licensing factor MCM6 (chains 6)
VDDVTGEKVREAFEQFLEDFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRE
NGALAMAISEQYYRFLPFLQKGLRRVVRKYAPXXXXXXXXXXXXXXERVFQISFFNLPTV
HRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKASFTCDMCRAIVDNVEQSFKYTEPTFC
PNPSCENRAFWTLNVTRSRFLDWQKVRIQENANEIPTGSMPRTLDVILRGDSVERAKPGD
RCKFTGVEIVVPDVTQLGLPGVKPSSTLDTRGISKTTEGLNSGVTGLRSLGVRDLTYKIS
FLACHVISIGXXXXXXXXXXXXXXXXXXXXXXXXXXSDEINELKEMVKDEHIYDKLVRSI
APAVFGHEAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAP
RSVYTSGKASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIH
EAMEQQTISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFF
VILDDCNEKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYL
VEKYKELRKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQ
SIIRVDV
Sequence of entity 11 (7), FASTA
>6U0M_11 DNA replication licensing factor MCM7 (chains 7)
MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKG
PKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRA
IDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDA
LREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLIT
VRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFM
STRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPY
TGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAP
EIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRG
VYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEV
MEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLM
LDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYV
VQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLV
RVSKESLYQ
Sequence of entity 12 (F), FASTA
>6U0M_12 DNA (26-MER) (chains F)
GATCGATCGATAAAGTTTTTTTT
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 3 |
Primary citation
DNA unwinding mechanism of a eukaryotic replicative CMG helicase. Yuan, Z., Georgescu, R., Bai, L. et al. Nat Commun (2020) 11:688. DOI 10.1038/s41467-020-14577-6
Other PDB entries of the same protein (UniProt Q12488 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 28VY 2.7 Å, sCMGE assembled on ARS1 DNA with Sld2 and RPA
- 8KG6 3.07 Å, Yeast replisome in state I
- 7PMK 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
- 7PMN 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
- 9E2Y 3.2 Å, Cryo-EM structure of yeast CMG helicase stalled at G4-containing DNA template, state 3
- 9RHI 3.2 Å, pre-Initiation Complex on ARS1 DNA (monomer)
- 9E2W 3.3 Å, Cryo-EM structure of yeast CMG helicase stalled at G4-containing DNA template, state 1
- 9RHJ 3.4 Å, Pre-Initiation Complex on ARS1 DNA (dimer)
- 8B9A 3.5 Å, S. cerevisiae replisome + Ctf4, bound by pol alpha primase. Complex engaged with a fork…
- 8B9B 3.5 Å, S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA…
- 9E2X 3.5 Å, Cryo-EM structure of yeast CMG helicase stalled at G4-containing DNA template, state 2
- 3JC6 3.7 Å, Structure of the eukaryotic replicative CMG helicase and pumpjack motion
Browse structure collections
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