Human Calcium-Sensing Receptor bound with L-Trp and calcium ions. Determined by electron microscopy at 3.5 Å resolution. Released 10 Mar 2021.
Explore 7DTV in 3D Show helices and sheets RCSB PDB PDBe
7DTV contains 74 α-helices and 68 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 26-28 | 3 | 1 |
| β-strand | 32-33 | 2 | 2 |
| β-strand | 36-38 | 3 | 1 |
| β-strand | 44 | 1 | 3 |
| α-helix | 54-55 | 2 | |
| α-helix | 57-59 | 3 | |
| β-strand | 60 | 1 | 3 |
| α-helix | 65-83 | 19 | |
| β-strand | 93-94 | 2 | 2 |
| β-strand | 95-99 | 5 | 1 |
| α-helix | 104-114 | 11 | |
| α-helix | 136-137 | 2 | |
| β-strand | 138 | 1 | 2 |
| β-strand | 141 | 1 | 4 |
| β-strand | 142-143 | 2 | 1 |
| α-helix | 150-153 | 4 | |
| β-strand | 164-166 | 3 | 4 |
| α-helix | 173-175 | 3 | |
| β-strand | 183-185 | 3 | 4 |
| α-helix | 193-203 | 11 | |
| β-strand | 209-214 | 6 | 5 |
| α-helix | 220-229 | 10 | |
| β-strand | 237-243 | 7 | 5 |
| α-helix | 249-260 | 12 | |
| β-strand | 266-270 | 5 | 5 |
| α-helix | 277-286 | 10 | |
| β-strand | 292-295 | 4 | 5 |
| α-helix | 308-310 | 3 | |
| β-strand | 325 | 1 | 6 |
| α-helix | 330-334 | 5 | |
| α-helix | 348-356 | 9 | |
| α-helix | 393-395 | 3 | |
| β-strand | 414 | 1 | 6 |
| α-helix | 416-435 | 20 | |
| α-helix | 437-438 | 2 | |
| α-helix | 445-447 | 3 | |
| α-helix | 457-465 | 9 | |
| β-strand | 469-470 | 2 | 7 |
| β-strand | 476-477 | 2 | 7 |
| β-strand | 484 | 1 | 4 |
| β-strand | 489 | 1 | 8 |
| β-strand | 492-495 | 4 | 9 |
| α-helix | 496-497 | 2 | |
| β-strand | 504-507 | 4 | 9 |
| β-strand | 509-511 | 3 | 8 |
| β-strand | 521-523 | 3 | 8 |
| β-strand | 530 | 1 | 10 |
| β-strand | 534 | 1 | 10 |
| α-helix | 537-539 | 3 | |
| α-helix | 544-546 | 3 | |
| β-strand | 550 | 1 | 11 |
| β-strand | 553-554 | 2 | 12 |
| β-strand | 563-564 | 2 | 12 |
| β-strand | 567 | 1 | 11 |
| β-strand | 589-590 | 2 | 13 |
| β-strand | 600-601 | 2 | 13 |
| α-helix | 614-636 | 23 | |
| α-helix | 653-663 | 11 | |
| α-helix | 664-666 | 3 | |
| α-helix | 674-678 | 5 | |
| α-helix | 682-690 | 9 | |
| α-helix | 693-696 | 4 | |
| α-helix | 728-730 | 3 | |
| α-helix | 732-745 | 14 | |
| α-helix | 771-779 | 9 | |
| α-helix | 783-786 | 4 | |
| α-helix | 788-791 | 4 | |
| α-helix | 803-826 | 24 | |
| α-helix | 831-834 | 4 | |
| α-helix | 837-850 | 14 | |
| α-helix | 853-857 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Extracellular calcium-sensing receptor | A, B | protein | 1099 | Homo sapiens | P41180 (AlphaFold model) |
>7DTV_1 Extracellular calcium-sensing receptor (chains A, B) MKTIIALSYIFCLVFADYKDDDDENLYFQGYGPDQRAQKKGDIILGGLFPIHFGVAAKDQ DLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALE ATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYAS SSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREE AEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNIT GKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAK EFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYI DYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNF TNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKIL WSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDF WSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRE LSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAK IPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGS LMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTY GKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATL RRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLT LPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTR HEPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGS TVTENVVNSHHHHHHHHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 8 |
| CA | Calcium ion | Ca | 4 |
| TRP | Tryptophan | C11 H12 N2 O2 | 2 |
Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan. Ling, S., Shi, P., Liu, S. et al. Cell Res (2021) 31:383-394. DOI 10.1038/s41422-021-00474-0 · PubMed
Other PDB entries of the same protein (UniProt P41180 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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