7F1R: Chemokine receptor CCR5

Cryo-EM structure of the chemokine receptor CCR5 in complex with RANTES and Gi. Determined by electron microscopy at 3.0 Å resolution. Released 14 Jul 2021.

Method: Electron microscopy
Resolution: 3.0 Å
Organism: Homo sapiens
Chains: 4
Atoms: 6,621
Mol. weight: 137.83 kDa
Released: 14 Jul 2021

Explore 7F1R in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7F1R contains 29 α-helices and 38 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	7-32	26
β-strand	34-39	6	3
β-strand	185-190	6	3
β-strand	195-200	6	3
α-helix	208-210	3
α-helix	212-215	4
β-strand	220-226	7	3
α-helix	242-254	13
β-strand	263-269	7	3
α-helix	273-280	8
α-helix	283-285	3
α-helix	296-310	15
β-strand	319-323	5	3
α-helix	328-351	24

Chain B: 3 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	30-34	5
α-helix	38-39	2
β-strand	47-51	5	4
β-strand	58-63	6	5
β-strand	69-74	6	5
β-strand	78-83	6	5
β-strand	88-94	7	5
β-strand	103-105	3	6
β-strand	111-114	4	6
β-strand	121-125	5	6
β-strand	134-139	6	6
α-helix	145	1
β-strand	146-151	6	7
β-strand	156-161	6	7
β-strand	165-170	6	7
β-strand	176-181	6	7
β-strand	187-192	6	8
β-strand	198-203	6	8
β-strand	207-212	6	8
β-strand	218-223	6	8
β-strand	229-234	6	9
β-strand	240-245	6	9
β-strand	249-254	6	9
β-strand	259-265	7	9
β-strand	273-278	6	10
β-strand	284-289	6	10
β-strand	294-298	5	10
β-strand	304-308	5	10
β-strand	315-320	6	4
β-strand	327-331	5	4
β-strand	336-339	4	4

Chain C: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	30-44	15
α-helix	53-55	3

Chain R: 16 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	4-6	3
β-strand	28	1	1
β-strand	40	1	1
α-helix	57-64	8
α-helix	129-149	21
α-helix	150-154	5
α-helix	159-175	17
α-helix	178-184	7
α-helix	193-225	33
α-helix	228-234	7
α-helix	237-260	24
β-strand	262-263	2	2
β-strand	274-275	2	2
α-helix	282-294	13
α-helix	295-299	5
α-helix	300-316	17
α-helix	322-355	34
α-helix	365-389	25
α-helix	390-394	5
α-helix	397-407	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
C-C motif chemokine 5,C-C chemokine receptor type 5	R	protein	462	Homo sapiens	P13501 (AlphaFold model), P51681 (AlphaFold model)
Guanine nucleotide-binding protein G(i) subunit alpha-1	A	protein	354	Homo sapiens	P63096 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	B	protein	340	Homo sapiens	P62873 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	C	protein	71	Homo sapiens	P59768

Sequence of entity 1 (R), FASTA

>7F1R_1 C-C motif chemokine 5,C-C chemokine receptor type 5 (chains R)
SPYSSDTTPCCFAYIARPLPRAHIKEYCYTSGKCSNPAVVFVTRKNRQVCANPEKKWVRE
YINSLEMSEFLEGSGSGSGSGSGSGSGSGSGSGSGSDYQVSSPIYDINYYTSEPCQKINV
KQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPF
WAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFG
VVTSVITWVVAVFASLPNIIFTRSQKCGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVL
PLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFG
LNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKREFLEVL
FQGPGSWSHPQFEKGSGAGASAGSWSHPQFEKGSDYKDDDDK

Sequence of entity 2 (A), FASTA

>7F1R_2 Guanine nucleotide-binding protein G(i) subunit alpha-1 (chains A)
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKCTIVKQMKIIHEAG
YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMT
AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVK
TTGIVETHFTFKDLHFKMFDVTAQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHASMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAA
AYIQCQFEDLNKRKDTKEIYTHFTCSTDTKNVQFVFDAVTDVIIKNNLKDCGLF

Sequence of entity 3 (B), FASTA

>7F1R_3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains B)
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Sequence of entity 4 (C), FASTA

>7F1R_4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains C)
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

Primary citation

Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Zhang, H., Chen, K., Tan, Q. et al. Nat Commun (2021) 12:4151-4151. DOI 10.1038/s41467-021-24438-5 · PubMed

Other PDB entries of the same protein (UniProt P13501 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5COY 1.44 Å, Crystal structure of CC chemokine 5 (CCL5)
6STK 1.52 Å, Crystal structure of the CC-chemokine 5 (CCL5) E66S mutation
1B3A 1.6 Å, Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV…
1EQT 1.6 Å, Met-rantes
6AEZ 1.63 Å, Crystal structure of human CCL5 trimer
1U4P 1.7 Å, Crystal Structure of human RANTES mutant K45E
2VXW 1.7 Å, Structural and Functional Studies of the Potent Anti-HIV Chemokine Variant P2-RANTES
1U4L 2.0 Å, human RANTES complexed to heparin-derived disaccharide I-S
1U4M 2.0 Å, human RANTES complexed to heparin-derived disaccharide III-S
1U4R 2.2 Å, Crystal Structure of human RANTES mutant 44-AANA-47
5UIW 2.2 Å, Crystal Structure of CC Chemokine Receptor 5 (CCR5) in complex with high potency HIV…
5L2U 2.28 Å, Oligomer crystal structure of CC chemokine 5 (CCL5)

Browse structure collections

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