7UHG: PDB entry 7UHG

Human L-type voltage-gated calcium channel Cav1.3 at 3.0 Angstrom resolution. Determined by electron microscopy at 3.0 Å resolution. Released 11 May 2022.

Method
Electron microscopy
Resolution
3.0 Å
Organism
Homo sapiens
Chains
3
Atoms
20,414
Mol. weight
430.3 kDa
Ligands
3PE, CLR, CA, NAG
Released
11 May 2022

Explore 7UHG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7UHG contains 123 α-helices and 78 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 71 helices, 13 β-strands

ElementResiduesLengthSheet
α-helix129-14416
α-helix156-17924
α-helix196-21621
α-helix236-24813
α-helix249-2524
α-helix255-26612
α-helix269-29224
β-strand299-30353
β-strand30913
β-strand331-33553
α-helix350-36112
α-helix366-37611
α-helix382-3909
α-helix391-3966
α-helix397-41519
α-helix416-4194
α-helix421-43010
α-helix432-4398
α-helix518-5214
α-helix523-54119
α-helix549-57729
α-helix579-5846
α-helix586-60621
α-helix614-6196
α-helix622-6287
α-helix630-6323
α-helix637-6448
α-helix647-67226
α-helix691-70313
α-helix707-71610
α-helix727-7293
α-helix730-74617
α-helix748-7536
α-helix755-77117
α-helix877-8837
α-helix888-90417
α-helix914-94027
α-helix954-96916
α-helix980-9867
α-helix987-9893
α-helix991-9977
α-helix999-101416
α-helix1018-103720
β-strand104314
β-strand1058-106255
α-helix1063-10653
β-strand1070-107455
β-strand107814
α-helix1087-109812
α-helix1103-11119
α-helix1126-11283
α-helix1129-11357
α-helix1136-11438
α-helix1144-115815
α-helix1159-11613
α-helix1170-118011
α-helix1193-120210
α-helix1205-122319
α-helix1231-125929
α-helix1261-12644
α-helix1268-128720
α-helix1316-13194
α-helix1320-13223
α-helix1325-13306
α-helix1337-134913
α-helix1353-137220
β-strand137516
α-helix1376-13772
α-helix1392-140312
α-helix1408-14136
β-strand142017
β-strand142116
β-strand143317
α-helix1440-146425
α-helix1467-14704
α-helix1479-149113
β-strand1499-150028
α-helix1502-15043
α-helix1505-15106
α-helix1527-15337
β-strand1544-154528
α-helix1547-155711
α-helix1566-157510
α-helix1585-15884
Chain C: 11 helices, 10 β-strands
ElementResiduesLengthSheet
α-helix39-5517
β-strand62-6651
β-strand91-9881
β-strand103-10861
β-strand115-11951
α-helix121-13111
α-helix156-1583
β-strand171-17221
α-helix178-1792
β-strand180-18342
α-helix191-20717
β-strand212-21542
α-helix247-26216
β-strand266-26942
β-strand288-29252
α-helix297-30711
α-helix309-3135
α-helix315-32713
α-helix330-3323
β-strand335-33732
α-helix342-36019
Chain D: 41 helices, 55 β-strands
ElementResiduesLengthSheet
α-helix30-5122
α-helix54-6411
β-strand68-7259
α-helix75-10935
β-strand122-124310
β-strand125-126211
β-strand142-144310
β-strand150-152312
β-strand155-159512
β-strand160113
β-strand165-167311
α-helix177-1859
α-helix189-19911
β-strand206-210511
β-strand215-218411
β-strand220113
α-helix238-2403
α-helix242-2487
β-strand252-259814
α-helix262-2643
α-helix267-27913
α-helix280-2823
β-strand288114
β-strand289115
β-strand291-294414
β-strand298-300314
β-strand308115
α-helix312-32211
α-helix333-34311
β-strand355-362814
α-helix370-3767
β-strand383-389714
α-helix397-4059
β-strand410-413414
α-helix416-4183
α-helix419-4224
α-helix426-4305
α-helix432-4376
α-helix439-4413
β-strand445-446211
β-strand450-451211
β-strand458-4671011
β-strand484-4931011
α-helix494-4996
β-strand511-515516
β-strand520117
β-strand521-523316
α-helix531-5333
β-strand560117
α-helix561-5644
α-helix569-57911
β-strand584-5931016
β-strand599118
β-strand600-6111216
β-strand618-624716
β-strand629-63359
α-helix639-6468
α-helix650-6523
α-helix653-6564
β-strand658-659219
α-helix679-6879
α-helix700-71516
α-helix716-7205
β-strand729-736819
β-strand741-743319
α-helix746-7516
α-helix758-7603
α-helix762-7698
β-strand773120
β-strand774-776319
α-helix777-7793
β-strand792-797619
β-strand800-801221
β-strand806-807221
β-strand810-816719
α-helix818-8269
β-strand848-854722
β-strand858123
β-strand859-861322
β-strand874123
α-helix875-8773
α-helix880-8889
β-strand892-899818
β-strand903-904224
β-strand972-973224
β-strand975-983918
β-strand989-994622
β-strand1001-1007722
α-helix10081
β-strand1011120
β-strand1013-1019722
α-helix1029-10324
β-strand1036-1038318
α-helix10401
α-helix10421
α-helix1050-10523

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Voltage-dependent L-type calcium channel subunit beta-3Cprotein484Homo sapiensP54284 (AlphaFold model)
Voltage-dependent L-type calcium channel subunit alpha-1DAprotein2161Homo sapiensQ01668 (AlphaFold model)
Voltage-dependent calcium channel subunit alpha-2/delta-1Dprotein1103Homo sapiensP54289 (AlphaFold model)
Sequence of entity 1 (C), FASTA
>7UHG_1 Voltage-dependent L-type calcium channel subunit beta-3 (chains C)
MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPV
AFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPS
PQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPV
VLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIER
SSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVL
QRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRAT
HHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQR
SSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWP
KDSY
Sequence of entity 2 (A), FASTA
>7UHG_2 Voltage-dependent L-type calcium channel subunit alpha-1D (chains A)
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS
GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI
SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT
ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF
IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG
PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK
ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP
AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS
AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM
LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI
VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS
DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA
FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY
VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK
PKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRL
FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDN
NQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFA
IVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRI
KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI
KTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFK
KRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFK
RNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNH
HNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSS
VKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTW
SRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRR
SSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRS
WATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPAS
LTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEME
SAASTLLNGNVRPRANGDVGPLSHRQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITT
L
Sequence of entity 3 (D), FASTA
>7UHG_3 Voltage-dependent calcium channel subunit alpha-2/delta-1 (chains D)
MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDI
YEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASN
EVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVL
NELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRR
RPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQD
VSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIML
FTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIR
INTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLK
NQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTIN
LRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYI
DKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTF
IAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYW
SKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYF
NKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCD
CKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDY
QSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEM
EDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVES
KGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPS
LWYIIGIQFLLLWLVSGSTHRLL

Ligands and cofactors

IDNameFormulaCopies
3PE1,2-Distearoyl-sn-glycerophosphoethanolamineC41 H82 N O8 P1
CLRCholesterolC27 H46 O3
CACalcium ionCa2
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O62

Primary citation

Structural basis for pore blockade of human voltage-gated calcium channel Ca v 1.3 by motion sickness drug cinnarizine. Yao, X., Gao, S., Yan, N. Cell Res (2022) 32:946-948. DOI 10.1038/s41422-022-00663-5 · PubMed

Other PDB entries of the same protein (UniProt P54284 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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