7WLU: PDB entry 7WLU

The Flattened Structure of mPIEZO1 in Lipid Bilayer. Determined by electron microscopy at 6.81 Å resolution. Released 13 Apr 2022.

Method
Electron microscopy
Resolution
6.81 Å
Organism
Mus musculus
Chains
3
Atoms
34,761
Mol. weight
879.26 kDa
Ligands
PLX
Released
13 Apr 2022

Explore 7WLU in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7WLU contains 204 α-helices and 48 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, C and E: 68 helices, 16 β-strands

ElementResiduesLengthSheet
α-helix577-5848
α-helix587-59711
α-helix605-62420
α-helix626-6305
α-helix632-65221
α-helix657-66610
α-helix671-6766
α-helix683-70523
α-helix708-7158
α-helix785-82339
α-helix829-83911
α-helix845-86622
α-helix925-94925
α-helix966-9727
α-helix974-100532
α-helix1008-102215
α-helix1026-105126
α-helix1074-10796
α-helix1092-111423
α-helix1117-11226
α-helix1140-11423
α-helix1149-117527
α-helix1179-120022
α-helix1203-123331
α-helix1236-124813
α-helix1281-129818
α-helix1302-136362
α-helix1405-14095
α-helix1439-14468
α-helix1449-146719
α-helix1491-154656
α-helix1552-15587
α-helix1657-166812
α-helix1673-168614
α-helix1689-170113
α-helix1705-171814
α-helix1729-174820
α-helix1771-17744
α-helix1786-180318
α-helix1942-196726
α-helix1977-199317
α-helix1996-19983
α-helix2007-20137
α-helix2018-204023
α-helix2043-206018
α-helix2065-20684
α-helix2078-209922
α-helix2111-21133
α-helix2116-212611
α-helix2131-214212
α-helix2149-217426
α-helix2176-21783
α-helix2185-220824
α-helix2209-22135
β-strand221911
β-strand2223-2232102
β-strand2236-224382
β-strand2248-225033
α-helix2251-22522
α-helix2253-226210
α-helix2267-22759
α-helix2278-22803
β-strand2281-228443
β-strand2286-228724
α-helix2298-230912
β-strand2315-2325112
β-strand2335-2344102
α-helix2349-23579
β-strand2366-237275
β-strand2375-237843
α-helix23851
β-strand238613
α-helix23871
β-strand2399-2409115
α-helix2423-24253
β-strand2426-243495
β-strand2443-244424
β-strand2447-245043
β-strand245311
α-helix2466-248520
α-helix2501-251616
α-helix2519-253416
α-helix2536-25416
α-helix2545-25462

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Piezo-type mechanosensitive ion channel component 1A, C, Eprotein2547Mus musculusE2JF22 (AlphaFold model)
Sequence of entity 1 (A, C, E), FASTA
>7WLU_1 Piezo-type mechanosensitive ion channel component 1 (chains A, C, E)
MEPHVLGAGLYWLLLPCTLLAASLLRFNALSLVYLLFLLLLPWLPGPSRHSIPGHTGRLL
RALLCLSLLFLVAHLAFQICLHTVPHLDQFLGQNGSLWVKVSQHIGVTRLDLKDIFNTTR
LVAPDLGVLLASSLCLGLCGRLTRKAGQSRRTQELQDDDDDDDDDDEDIDAAPAVGLKGA
PALATKRRLWLASRFRVTAHWLLMTSGRTLVIVLLALAGIAHPSAFSSIYLVVFLAICTW
WSCHFPLSPLGFNTLCVMVSCFGAGHLICLYCYQTPFIQDMLPPGNIWARLFGLKNFVDL
PNYSSPNALVLNTKHAWPIYVSPGILLLLYYTATSLLKLHKSCPSELRKETPREDEEHEL
ELDHLEPEPQARDATQGEMPMTTEPDLDNCTVHVLTSQSPVRQRPVRPRLAELKEMSPLH
GLGHLIMDQSYVCALIAMMVWSIMYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLY
GLTLCCLRYVWAMELPELPTTLGPVSLHQLGLEHTRYPCLDLGAMLLYLLTFWLLLRQFV
KEKLLKKQKVPAALLEVTVADTEPTQTQTLLRSLGELVTGIYVKYWIYVCAGMFIVVSFA
GRLVVYKIVYMFLFLLCLTLFQVYYTLWRKLLRVFWWLVVAYTMLVLIAVYTFQFQDFPT
YWRNLTGFTDEQLGDLGLEQFSVSELFSSILIPGFFLLACILQLHYFHRPFMQLTDLEHV
PPPGTRHPRWAHRQDAVSEAPLLEHQEEEEVFREDGQSMDGPHQATQVPEGTASKWGLVA
DRLLDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFAL
PYPRFRPMASCLSTVWTCIIIVCKMLYQLKIVNPHEYSSNCTEPFPNNTNLQPLEINQSL
LYRGPVDPANWFGVRKGYPNLGYIQNHLQILLLLVFEAVVYRRQEHYRRQHQQAPLPAQA
VCADGTRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAI
LTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPALCIDYPWRWSKAIPMNSALIKWL
YLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGINTDHLEPLRGEPNPI
PNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQ
KDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSNFCWVIQLFSLVCTVKGYYD
PKEMMTRDRDCLLPVEEAGIIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGF
ALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSKDPQDPSQE
PGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLFESDSEEEEEALPEDPRPAAQSAFQM
AYQAWVTNAQTVLRQRRERARQERAEQLASGGDLNPDVEPVDVPEDEMAGRSHMMQRVLS
TMQFLWVLGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLY
VGEDEATLSGPVETRDGPSTASSGLGAEEPLSSMTDDTSSPLSTGYNTRSGSEEIVTDAG
DLQAGTSLHGSQELLANARTRMRTASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGY
QCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVM
VVTKYLFQFGFFPWNSYVVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQL
LCYGLWDHEEDRYPKDHCRSSVKDREAKEEPEAKLESQSETGTGHPKEPVLAGTPRDHIQ
GKGSIRSKDVIQDPPEDLKPRHTRHISIRFRRRKETPGPKGTAVMETEHEEGEGKETTER
KRPRHTQEKSKFRERMKAAGRRLQSFCVSLAQSFYQPLQRFFHDILHTKYRAATDVYALM
FLADIVDIIIIIFGFWAFGKHSAATDIASSLSDDQVPQAFLFMLLVQFGTMVIDRALYLR
KTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCG
YPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYA
NIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVV
NQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPED
IVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKH
TLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLG
VRIQLRREQVGTGASGEQAGTKASDFLEWWVIELQDCKADCNLLPMVIFSDKVSPPSLGF
LAGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELE
LEEELYAKLIFLYRSPETMIKWTRERE

Ligands and cofactors

IDNameFormulaCopies
PLX(9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2L…C42 H89 N O8 P3

Primary citation

Structure deformation and curvature sensing of PIEZO1 in lipid membranes. Yang, X., Lin, C., Chen, X. et al. Nature (2022) 604:377-383. DOI 10.1038/s41586-022-04574-8 · PubMed

Other PDB entries of the same protein (UniProt E2JF22 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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