Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with Coenzyme A. Determined by X-ray diffraction at 2.25 Å resolution. Released 6 Mar 2024.
Explore 8CMZ in 3D Show helices and sheets RCSB PDB PDBe
8CMZ contains 29 α-helices and 16 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1087-1102 | 16 | |
| α-helix | 1109-1111 | 3 | |
| α-helix | 1117-1120 | 4 | |
| α-helix | 1125-1128 | 4 | |
| α-helix | 1135-1144 | 10 | |
| α-helix | 1150-1167 | 18 | |
| α-helix | 1173-1195 | 23 | |
| β-strand | 1205 | 1 | 1 |
| α-helix | 1206-1208 | 3 | |
| α-helix | 1276 | 1 | |
| β-strand | 1277 | 1 | 1 |
| α-helix | 1278-1279 | 2 | |
| β-strand | 1280-1282 | 3 | 2 |
| β-strand | 1289-1291 | 3 | 2 |
| α-helix | 1292-1295 | 4 | |
| α-helix | 1310-1314 | 5 | |
| α-helix | 1317-1321 | 5 | |
| α-helix | 1333-1349 | 17 | |
| β-strand | 1357-1370 | 14 | 3 |
| α-helix | 1371-1372 | 2 | |
| α-helix | 1373-1379 | 7 | |
| β-strand | 1388-1402 | 15 | 3 |
| β-strand | 1405-1417 | 13 | 3 |
| α-helix | 1422 | 1 | |
| β-strand | 1428-1436 | 9 | 3 |
| α-helix | 1443-1464 | 22 | |
| β-strand | 1468-1472 | 5 | 3 |
| α-helix | 1492-1495 | 4 | |
| α-helix | 1496-1512 | 17 | |
| β-strand | 1518-1521 | 4 | 3 |
| α-helix | 1522-1526 | 5 | |
| α-helix | 1534-1536 | 3 | |
| α-helix | 1544-1551 | 8 | |
| α-helix | 1621-1627 | 7 | |
| α-helix | 1629-1631 | 3 | |
| β-strand | 1632-1636 | 5 | 3 |
| α-helix | 1654-1655 | 2 | |
| α-helix | 1659-1661 | 3 | |
| α-helix | 1665-1674 | 10 | |
| α-helix | 1681-1697 | 17 | |
| β-strand | 1706 | 1 | 4 |
| β-strand | 1713 | 1 | 4 |
| β-strand | 1718-1720 | 3 | 5 |
| β-strand | 1727-1728 | 2 | 5 |
| β-strand | 1742-1744 | 3 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| histone acetyltransferase | A | protein | 640 | Mus musculus | P45481 (AlphaFold model) |
>8CMZ_1 histone acetyltransferase (chains A) HHHHHHDYDIPTTENLYFQGAMGSSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQ PVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSR VYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNR YHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQI CVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPE AGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMH VQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLCTAVYHEILIGYLEYVKKLGYVTGHIWA CPPSEGDDYIFHCHPPDQKIPKPKRLQEWFKKMLDKAFAERIINDYKDIFKQANEDRLTS AKELPYFEGDFWPNVLEESIKESGGSGSQKLYATMEKHKEVFFVIHLHAGPVISTQPPIV DPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNEC KHHVETRWHCTVCEDYDLCINCYNTKSHTHKMVKWGLGLD
Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with Coenzyme A. Mechaly, A.E., Zhang, W., Haouz, A. et al. To be published.
Other PDB entries of the same protein (UniProt P45481 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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