Crystal structure of CREBBP-Y1503C histone acetyltransferase domain in complex with Coenzyme A. Determined by X-ray diffraction at 1.99 Å resolution. Released 6 Mar 2024.
Explore 8CNB in 3D Show helices and sheets RCSB PDB PDBe
8CNB contains 31 α-helices and 16 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1087-1102 | 16 | |
| α-helix | 1109-1111 | 3 | |
| α-helix | 1117-1120 | 4 | |
| α-helix | 1125-1128 | 4 | |
| α-helix | 1135-1144 | 10 | |
| α-helix | 1150-1167 | 18 | |
| α-helix | 1173-1195 | 23 | |
| β-strand | 1205 | 1 | 1 |
| α-helix | 1206-1208 | 3 | |
| α-helix | 1276 | 1 | |
| β-strand | 1277 | 1 | 1 |
| α-helix | 1278-1279 | 2 | |
| β-strand | 1280-1282 | 3 | 2 |
| β-strand | 1289-1291 | 3 | 2 |
| α-helix | 1292-1295 | 4 | |
| α-helix | 1309-1315 | 7 | |
| α-helix | 1319-1321 | 3 | |
| α-helix | 1330-1331 | 2 | |
| α-helix | 1333-1349 | 17 | |
| β-strand | 1357-1370 | 14 | 3 |
| α-helix | 1371-1372 | 2 | |
| α-helix | 1373-1379 | 7 | |
| β-strand | 1388-1402 | 15 | 3 |
| β-strand | 1405-1417 | 13 | 3 |
| α-helix | 1422 | 1 | |
| β-strand | 1428-1436 | 9 | 3 |
| α-helix | 1443-1445 | 3 | |
| α-helix | 1446-1464 | 19 | |
| β-strand | 1468-1472 | 5 | 3 |
| α-helix | 1475-1476 | 2 | |
| α-helix | 1496-1512 | 17 | |
| β-strand | 1518-1521 | 4 | 3 |
| α-helix | 1522-1526 | 5 | |
| α-helix | 1534-1536 | 3 | |
| α-helix | 1544-1551 | 8 | |
| α-helix | 1621-1627 | 7 | |
| α-helix | 1629-1631 | 3 | |
| β-strand | 1632-1636 | 5 | 3 |
| α-helix | 1654-1655 | 2 | |
| α-helix | 1659-1661 | 3 | |
| α-helix | 1665-1674 | 10 | |
| α-helix | 1681-1698 | 18 | |
| β-strand | 1706 | 1 | 4 |
| β-strand | 1713 | 1 | 4 |
| β-strand | 1718-1720 | 3 | 5 |
| β-strand | 1727-1728 | 2 | 5 |
| β-strand | 1742-1744 | 3 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| histone acetyltransferase | A | protein | 619 | Mus musculus | P45481 (AlphaFold model) |
>8CNB_1 histone acetyltransferase (chains A) MGSSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMD LSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQ SLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDD PSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKK TGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPG MKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYL DSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIP KPKRLQEWCKKMLDKAFAERIINDYKDIFKQANEDRLTSAKELPYFEGDFWPNVLEESIK ESGGSGSQKLYATMEKHKEVFFVIHLHAGPVISTQPPIVDPDPLLSCDLMDGRDAFLTLA RDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCIN CYNTKSHTHKMVKWGLGLD
Crystal structure of CREBBP-Y1503C histone acetyltransferase domain in complex with Coenzyme A. Mechaly, A.E., Zhang, W., Haouz, A. et al. To be published.
Other PDB entries of the same protein (UniProt P45481 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 8CNB directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.