8P4A: DNA-directed RNA polymerase subunit

Name: PDB 8P4A: Structural insights into human co-transcriptional capping - structure 1
Published: 2023-08-16
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Structural insights into human co-transcriptional capping - structure 1. Determined by electron microscopy at 3.6 Å resolution. Released 16 Aug 2023.

Method: Electron microscopy
Resolution: 3.6 Å
Organisms: Sus scrofa, unidentified, Homo sapiens
Chains: 16
Atoms: 36,673
Mol. weight: 614.72 kDa
Ligands: MG, ZN
Released: 16 Aug 2023

Explore 8P4A in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8P4A contains 205 α-helices and 252 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 76 helices, 67 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	1
β-strand	20-25	6	2
α-helix	26-27	2
α-helix	28-34	7
β-strand	47-48	2	3
β-strand	51-52	2	3
α-helix	53	1
β-strand	86-88	3	4
β-strand	94-95	2	5
α-helix	99-109	11
α-helix	124-132	9
α-helix	137-148	12
β-strand	190-194	5	6
β-strand	197-201	5	6
β-strand	213-215	3	6
α-helix	216-217	2
α-helix	218-225	8
α-helix	230-236	7
α-helix	245-248	4
β-strand	249-250	2	5
β-strand	253-255	3	4
α-helix	256	1
α-helix	275-292	18
α-helix	293-297	5
α-helix	302-318	17
α-helix	326-328	3
α-helix	334-336	3
α-helix	339-344	6
α-helix	350-355	6
β-strand	357-359	3	7
β-strand	362-369	8	8
β-strand	377-380	4	8
α-helix	382-385	4
β-strand	389-393	5	9
α-helix	394	1
α-helix	399-408	10
β-strand	416-420	5	9
β-strand	426-428	3	9
α-helix	435-438	4
β-strand	445-449	5	9
α-helix	450	1
β-strand	455-459	5	8
α-helix	466-468	3
β-strand	469-476	8	8
β-strand	482-484	3	8
α-helix	489-492	4
β-strand	500-504	5	8
α-helix	509-518	10
β-strand	520	1	8
α-helix	521-524	4
β-strand	526	1	10
β-strand	533	1	10
α-helix	539-548	10
β-strand	554-555	2	11
α-helix	557-563	7
α-helix	564-566	3
α-helix	574	1
β-strand	575	1	12
α-helix	576-577	2
β-strand	579-581	3	13
β-strand	585	1	13
β-strand	586-587	2	11
α-helix	588-595	8
β-strand	602-605	4	14
β-strand	627-631	5	14
β-strand	634-637	4	14
α-helix	642-645	4
α-helix	652-659	8
α-helix	663-683	21
β-strand	685-686	2	15
α-helix	689-691	3
α-helix	696-721	26
α-helix	726-728	3
α-helix	733-756	24
α-helix	765-771	7
α-helix	778-785	8
β-strand	789-790	2	16
β-strand	793	1	17
β-strand	796	1	17
β-strand	802	1	18
β-strand	805	1	18
β-strand	822-823	2	16
α-helix	833-867	35
β-strand	872-873	2	19
β-strand	879-880	2	19
β-strand	886-888	3	19
α-helix	891-893	3
β-strand	896	1	20
β-strand	902-905	4	21
α-helix	913-920	8
α-helix	927-933	7
β-strand	934	1	22
α-helix	936-944	9
α-helix	947-969	23
β-strand	976-979	4	21
α-helix	983-994	12
β-strand	1002	1	22
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1053	3
α-helix	1054-1058	5
α-helix	1062-1078	17
β-strand	1080	1	20
α-helix	1081-1082	2
α-helix	1087-1101	15
α-helix	1121-1128	8
β-strand	1139-1140	2	23
β-strand	1141-1142	2	24
β-strand	1143	1	25
α-helix	1146-1149	4
α-helix	1151-1159	9
β-strand	1164	1	26
β-strand	1170-1177	8	27
α-helix	1190-1193	4
β-strand	1210-1216	7	27
α-helix	1219-1223	5
α-helix	1228-1239	12
α-helix	1240-1242	3
β-strand	1243-1246	4	27
β-strand	1255-1261	7	27
α-helix	1282-1295	14
β-strand	1299	1	26
β-strand	1308-1310	3	24
β-strand	1319-1322	4	28
β-strand	1328-1331	4	28
β-strand	1335-1337	3	24
β-strand	1352	1	25
β-strand	1358-1359	2	23
α-helix	1362-1368	7
α-helix	1372-1387	16
α-helix	1395-1404	10
α-helix	1416-1419	4
α-helix	1426-1430	5
α-helix	1436-1444	9
β-strand	1448-1449	2	2
α-helix	1455-1460	6
α-helix	1463-1464	2
β-strand	1472-1475	4	29
α-helix	1483	1
β-strand	1484	1	30
α-helix	1485-1486	2

Chain B: 51 helices, 77 β-strands

Element	Residues	Length	Sheet
α-helix	22-36	15
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-64	2
β-strand	65-67	3	31
β-strand	84-93	10	31
β-strand	97-98	2	32
β-strand	106-107	2	32
α-helix	110-115	6
β-strand	121-131	11	31
β-strand	141-153	13	31
β-strand	155	1	33
α-helix	168-173	6
β-strand	185-187	3	33
β-strand	190-194	5	33
β-strand	196-200	5	34
α-helix	201	1
β-strand	206-208	3	35
β-strand	215-223	9	35
β-strand	233-240	8	35
α-helix	241	1
β-strand	256-259	4	35
β-strand	263	1	36
β-strand	267-268	2	35
α-helix	269-275	7
α-helix	281-288	8
α-helix	295-307	13
α-helix	314-322	9
β-strand	325	1	36
α-helix	336-345	10
α-helix	355-357	3
α-helix	358-377	20
α-helix	381-384	4
α-helix	388-390	3
β-strand	391-394	4	34
α-helix	396-423	28
α-helix	431-434	4
α-helix	438-450	13
β-strand	467-469	3	33
α-helix	470-471	2
α-helix	475-481	7
β-strand	484-486	3	34
α-helix	503-505	3
β-strand	509	1	37
β-strand	524-525	2	34
β-strand	526	1	37
β-strand	527	1	38
β-strand	531-532	2	39
α-helix	539-547	9
β-strand	550-552	3	40
α-helix	553-555	3
β-strand	565-569	5	40
β-strand	572-577	6	40
α-helix	584-591	8
β-strand	602-606	5	40
β-strand	611-615	5	40
β-strand	621-627	7	39
β-strand	628	1	41
β-strand	633	1	41
α-helix	637-644	8
α-helix	653-658	6
β-strand	662-666	5	39
α-helix	667-670	4
β-strand	675-676	2	39
α-helix	679-682	4
β-strand	695-696	2	39
α-helix	700-703	4
β-strand	705	1	38
α-helix	708-710	3
α-helix	714-716	3
α-helix	719-729	11
β-strand	732	1	42
β-strand	748-751	4	43
β-strand	755	1	44
β-strand	759-760	2	45
α-helix	764-767	4
β-strand	776-782	7	46
β-strand	783-784	2	15
β-strand	793-797	5	46
α-helix	798-802	5
β-strand	808-817	10	43
β-strand	827-829	3	47
β-strand	838	1	47
β-strand	848	1	48
β-strand	853	1	49
β-strand	854	1	48
α-helix	855	1
β-strand	859-860	2	43
β-strand	865-867	3	49
β-strand	869-871	3	47
β-strand	890-891	2	47
β-strand	894-895	2	49
α-helix	896-897	2
β-strand	902-911	10	43
β-strand	917-927	11	43
β-strand	934-936	3	46
β-strand	942-949	8	46
β-strand	956	1	50
β-strand	965-967	3	46
α-helix	971-975	5
α-helix	978-993	16
β-strand	997-998	2	45
α-helix	1008-1016	9
β-strand	1025-1026	2	46
α-helix	1028	1
β-strand	1029	1	50
α-helix	1030	1
α-helix	1035	1
β-strand	1036	1	50
α-helix	1037	1
β-strand	1041-1050	10	46
β-strand	1051	1	42
β-strand	1060-1062	3	8
β-strand	1067	1	51
β-strand	1074	1	51
α-helix	1078-1080	3
β-strand	1084-1086	3	7
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1115-1119	5	1
β-strand	1125	1	1
β-strand	1127-1129	3	52
β-strand	1134-1136	3	52
β-strand	1146-1150	5	1
α-helix	1153-1164	12
β-strand	1167-1172	6	2

Chain C: 12 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	53
β-strand	18-24	7	53
α-helix	28-36	9
α-helix	37-41	5
β-strand	44-55	12	54
α-helix	61-69	9
β-strand	73	1	55
α-helix	82-84	3
α-helix	85-87	3
β-strand	99-106	8	54
β-strand	113-116	4	56
α-helix	117-119	3
β-strand	121-122	2	54
β-strand	129	1	55
α-helix	145-147	3
β-strand	149-153	5	56
β-strand	158-168	11	54
α-helix	174-176	3
β-strand	179-185	7	53
α-helix	200-202	3
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-235	7	53
α-helix	241-270	30

Chain D: 9 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	57
α-helix	17-19	3
β-strand	21	1	57
α-helix	24-27	4
β-strand	30-31	2	29
α-helix	34-49	16
α-helix	59-70	12
α-helix	77-87	11
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14

Chain E: 11 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	4-24	21
β-strand	26	1	58
α-helix	30-33	4
α-helix	37-44	8
β-strand	63	1	59
β-strand	64	1	58
β-strand	71	1	59
β-strand	75	1	60
α-helix	84-96	13
β-strand	102-106	5	60
α-helix	109-111	3
α-helix	112-119	8
β-strand	127-131	5	60
α-helix	132-136	5
α-helix	139-141	3
β-strand	147-150	4	61
α-helix	151-152	2
α-helix	153-163	11
β-strand	172-173	2	62
α-helix	178-183	6
β-strand	191-197	7	61
β-strand	201-207	7	61
β-strand	208-209	2	62

Chain F: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	63
α-helix	59-74	16
α-helix	77-78	2
β-strand	79	1	30
α-helix	89-99	11
β-strand	104-109	6	29
β-strand	115-119	5	29
β-strand	124	1	63
α-helix	125	1

Chain G: 4 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	2-13	12	29
α-helix	15-17	3
α-helix	23-33	11
β-strand	38-39	2	29
β-strand	43-54	12	29
β-strand	58-59	2	29
α-helix	60	1
β-strand	66-77	12	29
β-strand	84-92	9	64
β-strand	97-101	5	64
β-strand	104-107	4	64
α-helix	110-112	3
β-strand	118-120	3	65
β-strand	127-129	3	65
β-strand	136-137	2	65
β-strand	142-152	11	64
β-strand	157-162	6	64
β-strand	169-170	2	64

Chain H: 1 helix, 14 β-strands

Element	Residues	Length	Sheet
β-strand	4-15	12	66
β-strand	25-32	8	66
β-strand	38-44	7	66
β-strand	55-61	7	66
β-strand	65	1	67
β-strand	74	1	12
β-strand	83	1	67
α-helix	84-87	4
β-strand	90	1	66
β-strand	91-92	2	13
β-strand	94-101	8	66
β-strand	111-118	8	66
β-strand	121-128	8	66
β-strand	140-141	2	66
β-strand	145-148	4	66

5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1984	Sus scrofa	A0A7M4DUC2
RNA (5'-r(papapapapcpcpcpapgpgpgpapapcpcpcpapcp*u)-3')	P	RNA	19	unidentified
DNA-directed RNA polymerase subunit beta	B	protein	1174	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	I3LCH3 (AlphaFold model)
RNA polymerase II subunit D	D	protein	142	Sus scrofa	A0A4X1VM56 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7
DNA-directed RNA polymerase II subunit F	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A8W4F9W9
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Sus scrofa	F1RKE4

4 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>8P4A_1 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPT
SPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSY
SPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTS
PKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDS
DEEN

Sequence of entity 2 (P), FASTA

>8P4A_2 RNA (5'-R(P*AP*AP*AP*AP*CP*CP*CP*AP*GP*GP*GP*AP*AP*CP*CP*CP*AP*CP*U)-3') (chains P)
AAAACCCAGGGAACCCACU

Sequence of entity 3 (B), FASTA

>8P4A_3 DNA-directed RNA polymerase subunit beta (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 4 (C), FASTA

>8P4A_4 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 5 (D), FASTA

>8P4A_5 RNA polymerase II subunit D (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 6 (E), FASTA

>8P4A_6 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 7 (F), FASTA

>8P4A_7 DNA-directed RNA polymerase II subunit F (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 8 (G), FASTA

>8P4A_8 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 9 (H), FASTA

>8P4A_9 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 10 (I), FASTA

>8P4A_10 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 11 (J), FASTA

>8P4A_11 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 12 (K), FASTA

>8P4A_12 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	8

Primary citation

Structural insights into human co-transcriptional capping. Garg, G., Dienemann, C., Farnung, L. et al. Mol Cell (2023) 83:2464-2477.e5. DOI 10.1016/j.molcel.2023.06.002 · PubMed

Other PDB entries of the same protein (UniProt A0A7M4DUC2), best resolution first:

9BZ0 1.9 Å, Structure of an STK19-containing TC-NER complex
8S52 2.9 Å, RNA polymerase II core initially transcribing complex with an ordered RNA of 10 nt
9EGX 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27
9EGY 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27
9EGZ 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27
7UNC 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome
7UND 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38)
8A40 3.0 Å, Structure of mammalian Pol II-TFIIS elongation complex
6TED 3.1 Å, Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers…
9EH2 3.1 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream
8A3Y 3.3 Å, Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex
9ER2 3.3 Å, PolII-TCR-STK19 structure.

Browse structure collections

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