8RX1: GTuRC-CM1dim complex
CryoEM structure of the gTuRC-CM1dim complex. Determined by electron microscopy at 3.57 Å resolution. Released 25 Sept 2024.
- Method
- Electron microscopy
- Resolution
- 3.57 Å
- Organisms
- Homo sapiens, Spodoptera frugiperda
- Chains
- 45
- Atoms
- 123,860
- Mol. weight
- 2969.31 kDa
- Released
- 25 Sept 2024
Explore 8RX1 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8RX1 contains 798 α-helices and 368 β-strands across 45 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 1: 18 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-6 | 3 | 1 |
| β-strand | 9-10 | 2 | 1 |
| α-helix | 14-29 | 16 | |
| β-strand | 31 | 1 | 2 |
| α-helix | 36 | 1 | |
| β-strand | 37 | 1 | 2 |
| α-helix | 38 | 1 | |
| β-strand | 52 | 1 | 3 |
| β-strand | 62 | 1 | 3 |
| β-strand | 66-67 | 2 | 1 |
| α-helix | 74-78 | 5 | |
| β-strand | 91-92 | 2 | 1 |
| α-helix | 104-127 | 24 | |
| β-strand | 132-140 | 9 | 1 |
| α-helix | 146-150 | 5 | |
| α-helix | 151-160 | 10 | |
| β-strand | 165-172 | 8 | 1 |
| α-helix | 184-193 | 10 | |
| α-helix | 194-198 | 5 | |
| β-strand | 201-206 | 6 | 1 |
| α-helix | 207-217 | 11 | |
| α-helix | 225-239 | 15 | |
| α-helix | 240-243 | 4 | |
| α-helix | 253-258 | 6 | |
| β-strand | 268-269 | 2 | 1 |
| β-strand | 270-273 | 4 | 4 |
| α-helix | 290-296 | 7 | |
| β-strand | 303 | 1 | 4 |
| β-strand | 317 | 1 | 5 |
| β-strand | 321-324 | 4 | 6 |
| α-helix | 332-343 | 12 | |
| β-strand | 357-360 | 4 | 6 |
| β-strand | 376-379 | 4 | 4 |
| β-strand | 381 | 1 | 5 |
| α-helix | 384-401 | 18 | |
| α-helix | 409-412 | 4 | |
| α-helix | 419-439 | 21 | |
Chain 2: 20 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-6 | 3 | 13 |
| β-strand | 9 | 1 | 13 |
| α-helix | 13-28 | 16 | |
| β-strand | 31 | 1 | 14 |
| α-helix | 36 | 1 | |
| β-strand | 37 | 1 | 14 |
| α-helix | 38 | 1 | |
| β-strand | 53-54 | 2 | 15 |
| β-strand | 60-61 | 2 | 15 |
| β-strand | 66 | 1 | 13 |
| α-helix | 75-78 | 4 | |
| α-helix | 82-85 | 4 | |
| α-helix | 104-112 | 9 | |
| α-helix | 117-126 | 10 | |
| β-strand | 132-140 | 9 | 13 |
| α-helix | 146-160 | 15 | |
| β-strand | 165-171 | 7 | 13 |
| β-strand | 172 | 1 | 16 |
| α-helix | 184-198 | 15 | |
| β-strand | 202-203 | 2 | 17 |
| β-strand | 206 | 1 | 16 |
| α-helix | 207-217 | 11 | |
| α-helix | 229-238 | 10 | |
| α-helix | 241-244 | 4 | |
| α-helix | 253-257 | 5 | |
| α-helix | 258-260 | 3 | |
| β-strand | 268-272 | 5 | 17 |
| α-helix | 293-297 | 5 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303 | 1 | 17 |
| β-strand | 317 | 1 | 18 |
| β-strand | 320-326 | 7 | 17 |
| α-helix | 333-343 | 11 | |
| β-strand | 356-358 | 3 | 17 |
| β-strand | 361-362 | 2 | 17 |
| β-strand | 373-380 | 8 | 17 |
| β-strand | 381 | 1 | 18 |
| α-helix | 385-399 | 15 | |
| α-helix | 409-414 | 6 | |
| α-helix | 422-437 | 16 | |
Chain 7: 19 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-9 | 2 | 27 |
| β-strand | 16 | 1 | 28 |
| β-strand | 21 | 1 | 27 |
| β-strand | 32 | 1 | 28 |
| β-strand | 35 | 1 | 29 |
| β-strand | 54 | 1 | 29 |
| α-helix | 55-58 | 4 | |
| β-strand | 71 | 1 | 30 |
| β-strand | 76 | 1 | 30 |
| α-helix | 79-87 | 9 | |
| α-helix | 89-92 | 4 | |
| β-strand | 103-104 | 2 | 27 |
| α-helix | 114-121 | 8 | |
| α-helix | 122-126 | 5 | |
| β-strand | 131-133 | 3 | 27 |
| α-helix | 137-140 | 4 | |
| α-helix | 142-145 | 4 | |
| β-strand | 154-155 | 2 | 31 |
| β-strand | 161-162 | 2 | 32 |
| β-strand | 176-177 | 2 | 32 |
| α-helix | 184-195 | 12 | |
| α-helix | 205-212 | 8 | |
| α-helix | 223-227 | 5 | |
| α-helix | 228-232 | 5 | |
| α-helix | 251-256 | 6 | |
| α-helix | 258-261 | 4 | |
| α-helix | 274-283 | 10 | |
| α-helix | 291-294 | 4 | |
| β-strand | 297-298 | 2 | 33 |
| β-strand | 300 | 1 | 31 |
| α-helix | 301-304 | 4 | |
| α-helix | 310-320 | 11 | |
| β-strand | 329-330 | 2 | 33 |
| α-helix | 335-348 | 14 | |
| α-helix | 353-355 | 3 | |
| β-strand | 356-358 | 3 | 27 |
Chain a: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 13-34 | 22 | |
| α-helix | 41-52 | 12 | |
| α-helix | 57-73 | 17 | |
Chain A: 35 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 152-165 | 14 | |
| α-helix | 179-182 | 4 | |
| α-helix | 185-187 | 3 | |
| α-helix | 205-207 | 3 | |
| α-helix | 210-225 | 16 | |
| β-strand | 234 | 1 | 40 |
| α-helix | 236-238 | 3 | |
| β-strand | 247 | 1 | 40 |
| α-helix | 254-263 | 10 | |
| α-helix | 265-280 | 16 | |
| α-helix | 283-285 | 3 | |
| α-helix | 287-316 | 30 | |
| α-helix | 321-327 | 7 | |
| α-helix | 329-345 | 17 | |
| α-helix | 352-354 | 3 | |
| α-helix | 355-365 | 11 | |
| α-helix | 372-395 | 24 | |
| β-strand | 409-411 | 3 | 41 |
| α-helix | 428-431 | 4 | |
| β-strand | 432-434 | 3 | 41 |
| α-helix | 444-462 | 19 | |
| α-helix | 483-485 | 3 | |
| α-helix | 486-491 | 6 | |
| α-helix | 492-496 | 5 | |
| α-helix | 497-505 | 9 | |
| α-helix | 511-519 | 9 | |
| α-helix | 528-534 | 7 | |
| α-helix | 535-537 | 3 | |
| α-helix | 548-561 | 14 | |
| α-helix | 563-566 | 4 | |
| α-helix | 568-570 | 3 | |
| β-strand | 575-577 | 3 | 42 |
| β-strand | 616-618 | 3 | 42 |
| α-helix | 632-662 | 31 | |
| α-helix | 678-699 | 22 | |
| α-helix | 703-710 | 8 | |
| α-helix | 711-714 | 4 | |
| α-helix | 719-736 | 18 | |
| α-helix | 747-756 | 10 | |
| α-helix | 757-762 | 6 | |
| α-helix | 817-842 | 26 | |
Chain b: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-20 | 12 | |
| α-helix | 29-39 | 11 | |
| α-helix | 51-64 | 14 | |
| α-helix | 70-83 | 14 | |
| α-helix | 90-100 | 11 | |
Chain B: 38 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 247-258 | 12 | |
| β-strand | 263 | 1 | 43 |
| β-strand | 266-268 | 3 | 43 |
| β-strand | 275-277 | 3 | 43 |
| α-helix | 288-294 | 7 | |
| α-helix | 296-313 | 18 | |
| α-helix | 315-317 | 3 | |
| α-helix | 319-345 | 27 | |
| α-helix | 364-367 | 4 | |
| α-helix | 368-372 | 5 | |
| α-helix | 373-375 | 3 | |
| α-helix | 379-388 | 10 | |
| α-helix | 393-403 | 11 | |
| α-helix | 413-433 | 21 | |
| α-helix | 459-463 | 5 | |
| α-helix | 468-470 | 3 | |
| α-helix | 477-496 | 20 | |
| α-helix | 531-548 | 18 | |
| α-helix | 555-561 | 7 | |
| α-helix | 562-566 | 5 | |
| α-helix | 571-586 | 16 | |
| α-helix | 589-591 | 3 | |
| α-helix | 594-598 | 5 | |
| α-helix | 605-607 | 3 | |
| α-helix | 609-612 | 4 | |
| α-helix | 615-620 | 6 | |
| β-strand | 624-625 | 2 | 44 |
| α-helix | 634-637 | 4 | |
| β-strand | 638-639 | 2 | 44 |
| α-helix | 647-650 | 4 | |
| α-helix | 654-671 | 18 | |
| α-helix | 673-690 | 18 | |
| α-helix | 695-721 | 27 | |
| α-helix | 722-728 | 7 | |
| α-helix | 729-737 | 9 | |
| α-helix | 746-749 | 4 | |
| α-helix | 751-761 | 11 | |
| α-helix | 769-787 | 19 | |
| α-helix | 788-792 | 5 | |
| α-helix | 793-807 | 15 | |
| α-helix | 810-813 | 4 | |
| α-helix | 826-862 | 37 | |
| α-helix | 873-879 | 7 | |
| β-strand | 885 | 1 | 45 |
| β-strand | 889 | 1 | 45 |
Chain c: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-34 | 16 | |
| α-helix | 41-51 | 11 | |
| α-helix | 57-73 | 17 | |
36 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Tubulin gamma-1 chain | 1, 2, O, P, Q, R, S, T, U, V, W, X, Y, Z | protein | 451 | Homo sapiens | P23258 (AlphaFold model) |
| Actin b | 7 | protein | 364 | Spodoptera frugiperda | P60709 (AlphaFold model) |
| Gamma-tubulin complex component 2 | A, C, E, M, f, k | protein | 902 | Homo sapiens | Q9BSJ2 (AlphaFold model) |
| Gamma-tubulin complex component 3 | B, D, F, N, b, n | protein | 907 | Homo sapiens | Q96CW5 (AlphaFold model) |
| CM1 | G, H, g, h, i, j, s, t, u, v | protein | 229 | Homo sapiens | Q96SN8 |
| Gamma-tubulin complex component 4 | I, K | protein | 667 | Homo sapiens | Q9UGJ1 |
| Gamma-tubulin complex component 5 | J | protein | 1024 | Homo sapiens | Q96RT8 |
| Gamma-tubulin complex component 6 | L, d | protein | 1819 | Homo sapiens | Q96RT7 |
| Mitotic-spindle organizing protein 1 | a, c | protein | 82 | Homo sapiens | Q08AG7 |
| Mitotic-spindle organizing protein 2A | e | protein | 158 | Homo sapiens | Q6P582 |
Sequence of entity 1 (1, 2, O, P, Q, R, S, T, U, V, W, X, Y, Z), FASTA
>8RX1_1 Tubulin gamma-1 chain (chains 1, 2, O, P, Q, R, S, T, U, V, W, X, Y, Z)
MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHY
IPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFD
IIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSD
VVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSAST
TTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQP
KNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVAL
SRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQYDKLRKREAFLEQFRKEDMFKDNFDE
MDTSREIVQQLIDEYHAATRPDYISWGTQEQ
Sequence of entity 2 (7), FASTA
>8RX1_2 Actin b (chains 7)
DEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRKDSYVGDEAQSKRGILTLKYPI
EHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPA
MYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMK
ILTERGYSFTTTEEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELKDGQVITIG
NERFRCPEALFQPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIAD
RMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVH
RKCF
Sequence of entity 3 (A, C, E, M, f, k), FASTA
>8RX1_3 Gamma-tubulin complex component 2 (chains A, C, E, M, f, k)
MSEFRIHHDVNELLSLLRVHGGDGAEVYIDLLQKNRTPYVTTTVSAHSAKVKIAEFSRTP
EDFLKKYDELKSKNTRNLDPLVYLLSKLTEDKETLQYLQQNAKERAELAAAAVGSSTTSI
NVPAAASKISMQELEELRKQLGSVATGSTLQQSLELKRKMLRDKQNKKNSGQHLPIFPAW
VYERPALIGDFLIGAGISTDTALPIGTLPLASQESAVVEDLLYVLVGVDGRYVSAQPLAG
RQSRTFLVDPNLDLSIRELVHRILPVAASYSAVTRFIEEKSSFEYGQVNHALAAAMRTLV
KEHLILVSQLEQLHRQGLLSLQKLWFYIQPAMRTMDILASLATSVDKGECLGGSTLSLLH
DRSFSYTGDSQAQELCLYLTKAASAPYFEVLEKWIYRGIIHDPYSEFMVEEHELRKERIQ
EDYNDKYWDQRYTIVQQQIPSFLQKMADKILSTGKYLNVVRECGHDVTCPVAKEIIYTLK
ERAYVEQIEKAFNYASKVLLDFLMEEKELVAHLRSIKRYFLMDQGDFFVHFMDLAEEELR
KPVEDITPPRLEALLELALRMSTANTDPFKDDLKIDLMPHDLITQLLRVLAIETKQEKAM
AHADPTELALSGLEAFSFDYIVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQLCSVWI
SNKTAKQHSLHSAQWFAGAFTLRQRMLNFVQNIQYYMMFEVMEPTWHILEKNLKSASNID
DVLGHHTGFLDTCLKDCMLTNPELLKVFSKLMSVCVMFTNCMQKFTQSMKLDGELGGQTL
EHSTVLGLPAGAEERARKELARKHLAEHADTVQLVSGFEATINKFDKNFSAHLLDLLARL
SIYSTSDCEHGMASVISRLDFNGFYTERLERLSAERSQKATPQVPVLRGPPAPAPRVAVT
AQ
Sequence of entity 4 (B, D, F, N, b, n), FASTA
>8RX1_4 Gamma-tubulin complex component 3 (chains B, D, F, N, b, n)
MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKK
ELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLSLSEDPRRQPSKVSSYATLFAQ
ALPRDAHSTPYYYARPQTLPLSYQDRSAQSAQSSGSVGSSGISSIGLCALSGPAPAPQSL
LPGQSNQAPGVGDCLRQQLGSRLAWTLTANQPSSQATTSKGVPSAVSRNMTRSRREGDTG
GTMEITEAALVRDILYVFQGIDGKNIKMNNTENCYKVEGKANLSRSLRDTAVRLSELGWL
HNKIRRYTDQRSLDRSFGLVGQSFCAALHQELREYYRLLSVLHSQLQLEDDQGVNLGLES
SLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMRSLVQHILS
LVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFMTMDQS
RKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPQDAADLFTDLENAFQGKIDAAYFE
TSKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGI
LETAVRATNAQFDSPEILRRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHY
LRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQY
YITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIISRCLLDSDSRALLNQLRAVFD
QIIELQNAQDAIYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIGEFKESI
PKMCSQLRILTHFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAREPRLRVSLGTR
GRRSSHT
Sequence of entity 5 (G, H, g, h, i, j, s, t, u, v), FASTA
>8RX1_5 CM1 (chains G, H, g, h, i, j, s, t, u, v)
MGSSHHHHHHGSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLME
AFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGGAWSHPQFEKSAT
VSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGDDEAAELMQQVNVLKLT
VEDLEKERDFYFGKLRNIELICQENEGENDPVLQRIVDILYATDEGFVI
Sequence of entity 6 (I, K), FASTA
>8RX1_6 Gamma-tubulin complex component 4 (chains I, K)
MIHELLLALSGYPGSIFTWNKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIE
QYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLGDPHLSIS
HVNYFLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCH
GVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQD
LRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFENQNVNLTRKGSIL
KNQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEHLWKLMVEESDLLGQLKIIKDF
YLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDDDNLLPLLHLTIEY
HGKEHKADATQAREGPSRETSPREAPASGWAALGLSYKVQWPLHILFTPAVLEKYNVVFK
YLLSVRRVQAELQHCWALQMQRKHLKSNQTDAIKWRLRNHMAFLVDNLQYYLQVDVLESQ
FSQLLHQINSTRDFESIRLAHDHFLSNLLAQSFILLKPVFHCLNEILDLCHSFCSLVSQN
LGPLDERGAAQLSILVKGFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQAGG
TLGSFGM
Sequence of entity 7 (J), FASTA
>8RX1_7 Gamma-tubulin complex component 5 (chains J)
MARHGPPWSRLDAQQERDVRELVRGVAGLQDEADPNFQLALNFAWSNFRFHRFLDVNSHK
IEKTIEGIYEKFVIHSDLSKAASWKRLTEEFLNAPLPSIKEIKTDAHYSILSLLLCLSDS
PSNSSYVETPRNKEVEKKDDFDWGKYLMEDEEMDIGPYMDTPNWSEESEEENDQQPLSRE
DSGIQVDRTPLEEQDQNRKLDPCISWKDEPDDRSWLEHHVVHQYWTARPSQFPHSLHLHS
NLAAVWDQHLYSSDPLYVPDDRVLVTETQVIRETLWLLSGVKKLFIFQLIDGKVTVRNNI
IVTHLTHSCLRSVLEQIAAYGQVVFRLQEFIDEVMGHSSESMLPGSGSVPKKSTEAPFRT
YQAFMWALYKYFISFKEELAEIEKCIINNDTTITLAIVVDKLAPRLSQLKVLHKVFSTGV
AEVPPDTRNVVRASHLLNTLYKAILEYDNVGEASEQTVSLLFSLWVETVRPYLQTVDEWI
VHGHLWDGAREFIIQRNKNVPVNHRDFWYATYTLYSVSEKTENEEKMSDNASASSGSDQG
PSSRQHTMVSFLKPVLKQIIMAGKSMQLLKNLQCAESTTCQAGARDAERKSLYTLFLESV
QSRLRHGEDSTPQVLTEQQATKENLMKMQSIAESHLELDDVHDPLLAINFARMYLEQSDF
HEKFAGGDVCVDRSSESVTCQTFELTLRSCLYPHIDKQYLDCCGNLMQTLKKDYRLVEYL
QAMRNFFLMEGGDTMYDFYTSIFDKIREKETWQNVSFLNVQLQEAVGQRYPEDSSRLSIS
FENVDTAKKKLPVHILDGLTLSYKVPWPVDIVISLECQKIYNQVFLLLLQIKWAKYSLDV
LLFGELVSTAEKPRLKEGLIHEQDTVAQFGPQKEPVRQQIHRMFLLRVKLMHFVNSLHNY
IMTRILHSTGLEFQHQVEEAKDLDQLIKIHYRYLSTIHDRCLLREKVSFVKEAIMKVLNL
ALMFADGWQAGLGTWRMESIEKMESDFKNCHMFLVTILNKAVCRGSFPHLESLALSLMAG
MEQS
Sequence of entity 8 (L, d), FASTA
>8RX1_8 Gamma-tubulin complex component 6 (chains L, d)
MASITQLFDDLCEALLPAAKTHLGQRSVNRKRAKRSLKKVAYNALFTNLFQDETQQLQPD
MSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEVGSVLDLLVQLAGS
GPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQ
VMEAAPGTGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNAD
LSGLAIKVPPSVDQWEDEGFQSASNLTPDSQSEPSVTPDVDLWEAALTYEASKRRCWERV
GCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAPQPVLVKECELVKDVLNVL
IGVVSATFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPVLD
SLYSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVG
AVLPGTCGGGPRAAFPTGVKLLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWV
YSGVFRDAYGEFMIQVNHEYLSFRDKLYWTHGYVLISKEVEDCVPVFLKHIAHDIYVCGK
TINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEE
KELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERR
QAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALW
RIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGG
QGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFL
PVGPGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPA
VATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQ
PTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTH
GHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSNA
SIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGE
SVSDMAPTRPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSDVV
STRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSTVLDCGPR
LPVEVGPSLSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGDSVSEELGPGRSGDTEDL
SPNWPLNSQEDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSE
PPIAHLLRPVLPRAFAFPVDPQVQSAADETAVQLSELLTLPVLMKRSITAPLAAHISLVN
KAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNS
VLSKALQCSLHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGC
VSKYSGVFSFLLQLKLMMWALKDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVI
QGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSI
FSLVLKFRSQLISQAWGPPGGPRGAEHPNFALMQQSYNTFKYYSHFLFKVVTKLVNRGYQ
PHLEDFLLRINFNNYYQDA
Sequence of entity 9 (a, c), FASTA
>8RX1_9 Mitotic-spindle organizing protein 1 (chains a, c)
MASSSGAGAAAAAAAANLNAVRETMDVLLEISRILNTGLDMETLSICVRLCEQGINPEAL
SSVIKELRKATEALKAAENMTS
Sequence of entity 10 (e), FASTA
>8RX1_10 Mitotic-spindle organizing protein 2A (chains e)
MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGGIDPDVFKILV
DLLKLNVAPLAVFQMLKSMCAGQRLASEPQDPAAVSLPTSSVPETRGRDKGSAALGGVLA
LAERSNHEGSSQRMPRQPSATRLPKGGGPGKSPTQGST
Primary citation
CDK5RAP2 activates microtubule nucleator gamma TuRC by facilitating template formation and actin release. Serna, M., Zimmermann, F., Vineethakumari, C. et al. Dev Cell (2024) 59:3175. DOI 10.1016/j.devcel.2024.09.001 · PubMed
Other PDB entries of the same protein (UniProt P23258 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 3CB2 2.3 Å, Crystal structure of human gamma-tubulin bound to GDP
- 1Z5V 2.71 Å, Crystal structure of human gamma-tubulin bound to GTPgammaS
- 1Z5W 3.0 Å, Crystal Structure of gamma-tubulin bound to GTP
- 9SMX 3.67 Å, CM1-activated gTuRC in complex with nascent alpha-E254D mutant microtubules
- 8Q62 3.72 Å, Early closed conformation of the g-tubulin ring complex
- 6V5V 3.8 Å, Structure of gamma-tubulin in the native human gamma-tubulin ring complex
- 7AS4 4.13 Å, Recombinant human gTuRC
- 6V6S 4.3 Å, Structure of the native human gamma-tubulin ring complex
- 8VA2 4.5 Å, Symmetry expanded map of 2 gamma-tubulins bound to 2 alpha tubulins in gamma tubulin…
- 9H9P 4.5 Å, Spokes 12 and 13 of the human gamma-tubulin ring complex in complex with CDK5RAP2 and…
- 9QVN 4.7 Å, Cryo-EM reconstruction of the NEDD1 anchor protein bound to the gamma-tubulin ring complex
- 7QJ0 5.32 Å, Structure of recombinant human gamma-Tubulin Ring Complex 6-spoked assembly intermediate…
Browse structure collections
About this viewer
MolViewer shows 8RX1 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.