Tubulin gamma-1 chain (TUBG1) is a 451-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P23258.
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The mean pLDDT of this model is 91.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 77% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:38609661, PubMed:39321809). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). Plays a role in sperm morphological development during late stage spermiogenesis, particularly the anchoring of the…
Component of the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2 (PubMed:9566969, PubMed:39321809, PubMed:38609661, PubMed:38305685). TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 assemble in a 5:5:2:1:1 stoichiometry; each is associated with a gamma-tubulin, thereby arranging 14 gamma-tubulins in a helical manner…
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3CB2 | X-ray | 2.3 Å | A/B=1-451 |
| 1Z5V | X-ray | 2.71 Å | A=1-449 |
| 1Z5W | X-ray | 3.0 Å | A=1-449 |
| 8RX1 | EM | 3.57 Å | 1/2/O/P/Q/R/S/T/U/V/W/X/Y/Z=1-451 |
| 8Q62 | EM | 3.72 Å | a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-451 |
| 6V5V | EM | 3.8 Å | g=1-451 |
| 7AS4 | EM | 4.13 Å | 1/2/O/P/Q/R/S/T/U/V/W/X/Y/Z=1-447 |
| 6V6S | EM | 4.3 Å | a/b/c/d/e/f/g/h/i/j/k/l/m/t=1-451 |
| 8VA2 | EM | 4.5 Å | g/h=1-441 |
| 9H9P | EM | 4.5 Å | l/m=1-451 |
| 9QVN | EM | 4.7 Å | a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-451 |
| 7QJ0 | EM | 5.32 Å | U/V/W/X/Y/Z=1-451 |
| 9QVM | EM | 6.8 Å | a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-451 |
| 7QJ1 | EM | 7.0 Å | U/V/W/X/Y/Z=1-451 |
| 8VRD | EM | 7.0 Å | a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-451 |
| 7QJD | EM | 7.1 Å | 1/2/O/P/Q/R/S/T/U/V/W/X/Y/Z=1-451 |
| 7QJ3 | EM | 7.6 Å | 1/2/U/V/W/X/Y/Z=1-451 |
| 8VRJ | EM | 7.7 Å | a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-451 |
| 7QJ6 | EM | 7.8 Å | Q/R/S/T/U/V/W/X/Y/Z=1-451 |
| 7QJE | EM | 7.8 Å | W/X/Y/Z=1-451 |
Showing 20 of 32 experimental structures (best resolution first).
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