8S54: RNA polymerase II early elongation complex

RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state b (composite structure). Determined by electron microscopy at 3.4 Å resolution. Released 17 Apr 2024.

Method: Electron microscopy
Resolution: 3.4 Å
Organisms: Sus scrofa, unidentified adenovirus, Homo sapiens
Chains: 18
Atoms: 36,745
Mol. weight: 764.49 kDa
Ligands: MG, ZN
Released: 17 Apr 2024

Explore 8S54 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8S54 contains 191 α-helices and 253 β-strands across 15 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 71 helices, 62 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	1
β-strand	20-22	3	2
α-helix	28-34	7
α-helix	52-53	2
β-strand	86-94	9	3
α-helix	97-109	13
β-strand	110-111	2	4
β-strand	116-117	2	4
α-helix	124-132	9
α-helix	137-149	13
α-helix	187-189	3
β-strand	190-194	5	5
β-strand	197-201	5	5
β-strand	214-215	2	5
α-helix	218-226	9
α-helix	230-236	7
α-helix	240-242	3
α-helix	245-248	4
β-strand	250-255	6	3
β-strand	264	1	6
β-strand	272	1	6
α-helix	273-274	2
α-helix	275-295	21
α-helix	300-318	19
α-helix	326-328	3
β-strand	329	1	7
β-strand	335	1	7
α-helix	339-342	4
α-helix	350-355	6
β-strand	357-358	2	8
β-strand	362-369	8	9
β-strand	377-380	4	9
α-helix	382-387	6
β-strand	389-393	5	10
α-helix	399-408	10
β-strand	416-420	5	10
β-strand	426-428	3	10
β-strand	445-449	5	10
β-strand	455-459	5	9
α-helix	466-468	3
β-strand	469-476	8	9
β-strand	482-484	3	9
α-helix	487-489	3
β-strand	500-504	5	9
α-helix	509-518	10
β-strand	520	1	9
β-strand	526	1	11
β-strand	533	1	11
α-helix	541-549	9
β-strand	555	1	12
α-helix	557-563	7
α-helix	574-577	4
β-strand	579-581	3	13
β-strand	585	1	13
β-strand	586	1	12
α-helix	588-595	8
β-strand	602-604	3	14
α-helix	612-615	4
β-strand	628-631	4	14
β-strand	634-637	4	14
α-helix	642-645	4
α-helix	652-659	8
α-helix	663-683	21
α-helix	689-691	3
α-helix	696-721	26
α-helix	726-728	3
α-helix	733-758	26
α-helix	765-772	8
α-helix	778-785	8
β-strand	789	1	15
β-strand	793	1	16
β-strand	796	1	16
α-helix	811	1
α-helix	817-820	4
β-strand	823	1	15
α-helix	833-867	35
β-strand	872-873	2	17
β-strand	879-880	2	17
β-strand	886-888	3	17
α-helix	891-893	3
β-strand	896	1	18
β-strand	902-905	4	19
α-helix	913-920	8
α-helix	928-933	6
β-strand	934	1	20
α-helix	936-943	8
α-helix	946-969	24
β-strand	976-979	4	19
α-helix	983-993	11
α-helix	1001	1
β-strand	1002	1	20
α-helix	1006-1017	12
α-helix	1028-1048	21
α-helix	1051-1053	3
α-helix	1054-1058	5
α-helix	1062-1078	17
β-strand	1080	1	18
α-helix	1081-1082	2
α-helix	1087-1096	10
α-helix	1097-1100	4
α-helix	1121-1128	8
β-strand	1140-1142	3	21
β-strand	1143	1	22
α-helix	1146-1148	3
α-helix	1151-1161	11
α-helix	1166-1169	4
β-strand	1170-1177	8	23
α-helix	1190-1196	7
β-strand	1210-1216	7	23
α-helix	1218-1223	6
α-helix	1228-1238	11
β-strand	1243-1246	4	23
β-strand	1255-1261	7	23
α-helix	1282-1294	13
β-strand	1307-1310	4	21
β-strand	1319-1321	3	24
β-strand	1329-1331	3	24
β-strand	1335-1338	4	21
α-helix	1343-1346	4
β-strand	1352	1	22
α-helix	1363-1368	6
α-helix	1371-1386	16
α-helix	1395-1404	10
β-strand	1408-1409	2	25
α-helix	1419-1421	3
α-helix	1426-1429	4
α-helix	1435-1445	11
β-strand	1448-1449	2	2
α-helix	1455-1458	4
β-strand	1471-1475	5	26
α-helix	1477-1480	4
β-strand	1484	1	27

Chain B: 53 helices, 83 β-strands

Element	Residues	Length	Sheet
α-helix	22-36	15
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-60	6
β-strand	65-67	3	28
β-strand	83-87	5	28
β-strand	92-94	3	28
β-strand	97-99	3	29
β-strand	105-107	3	29
α-helix	108-109	2
α-helix	110-115	6
β-strand	121-133	13	28
β-strand	142-153	12	28
α-helix	168-173	6
β-strand	185-187	3	30
β-strand	190-193	4	30
α-helix	194-195	2
β-strand	196-200	5	31
α-helix	201	1
β-strand	208-209	2	32
β-strand	217-220	4	32
β-strand	223	1	33
β-strand	233	1	33
β-strand	236-239	4	32
α-helix	248-252	5
β-strand	256-259	4	32
β-strand	263	1	34
β-strand	266-268	3	32
α-helix	270-275	6
α-helix	281-288	8
α-helix	295-307	13
α-helix	308-310	3
α-helix	314-323	10
β-strand	325	1	34
α-helix	332-341	10
α-helix	342-346	5
α-helix	358-376	19
α-helix	382-384	3
β-strand	391-394	4	31
α-helix	396-423	28
α-helix	431-434	4
α-helix	437-449	13
β-strand	453	1	35
β-strand	463	1	35
β-strand	468-469	2	30
α-helix	470-471	2
α-helix	475-482	8
β-strand	484-486	3	31
β-strand	509	1	36
β-strand	524-525	2	31
β-strand	526	1	36
β-strand	527	1	37
β-strand	531-532	2	38
α-helix	533	1
α-helix	539-547	9
β-strand	551-552	2	39
α-helix	558-560	3
β-strand	565-569	5	39
β-strand	572-577	6	39
α-helix	580-592	13
β-strand	602-606	5	39
β-strand	611-615	5	39
β-strand	621-626	6	38
β-strand	628-629	2	40
β-strand	632-633	2	40
α-helix	637-644	8
α-helix	653-657	5
β-strand	662-666	5	38
α-helix	669-671	3
α-helix	679-683	5
α-helix	700-703	4
β-strand	705	1	37
α-helix	706-709	4
α-helix	719-728	10
α-helix	729-731	3
β-strand	732	1	41
β-strand	748-751	4	42
β-strand	755	1	43
β-strand	759-760	2	44
β-strand	776-782	7	45
β-strand	794-797	4	45
α-helix	798-802	5
β-strand	808-812	5	42
β-strand	815-817	3	46
β-strand	827-829	3	47
α-helix	831-833	3
β-strand	837	1	47
β-strand	848	1	48
β-strand	853	1	49
β-strand	854	1	48
α-helix	855	1
β-strand	859	1	42
β-strand	865-867	3	49
β-strand	869-872	4	47
α-helix	873	1
β-strand	889-891	3	47
β-strand	894-895	2	49
α-helix	896-897	2
β-strand	903-904	2	42
β-strand	908-911	4	46
β-strand	917-920	4	46
β-strand	923-927	5	42
β-strand	934-937	4	45
β-strand	943-949	7	45
β-strand	956	1	50
β-strand	965-967	3	45
α-helix	969-971	3
α-helix	978-993	16
α-helix	996	1
β-strand	997-998	2	44
α-helix	1008-1017	10
β-strand	1025-1026	2	45
β-strand	1029	1	50
α-helix	1035	1
β-strand	1036	1	50
α-helix	1037	1
β-strand	1041-1050	10	45
β-strand	1051	1	41
α-helix	1055-1058	4
β-strand	1060-1062	3	9
β-strand	1067	1	51
β-strand	1074	1	51
α-helix	1078-1080	3
β-strand	1085-1086	2	8
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1115-1119	5	1
β-strand	1125	1	1
β-strand	1127	1	52
β-strand	1136	1	52
β-strand	1137	1	53
β-strand	1142	1	53
β-strand	1146-1150	5	1
α-helix	1153-1164	12
β-strand	1170-1172	3	2

Chain C: 10 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	54
β-strand	18-24	7	54
α-helix	28-40	13
β-strand	44-55	12	55
α-helix	61-69	9
β-strand	73	1	56
α-helix	83-84	2
β-strand	99-106	8	55
α-helix	112	1
β-strand	113-116	4	57
α-helix	117-119	3
β-strand	121-122	2	55
β-strand	129	1	56
β-strand	149-153	5	57
β-strand	158-168	11	55
α-helix	174-176	3
β-strand	179	1	58
β-strand	184-186	3	54
α-helix	200-202	3
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-231	3	54
β-strand	233-234	2	54
β-strand	235	1	58
α-helix	243-270	28

Chain D: 10 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	59
β-strand	21	1	59
α-helix	24-26	3
β-strand	30	1	26
α-helix	31-33	3
α-helix	34-49	16
α-helix	55-58	4
α-helix	59-70	12
α-helix	77-89	13
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14

Chain E: 9 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	3-24	22
β-strand	26	1	60
α-helix	30-33	4
α-helix	37-43	7
β-strand	60-62	3	61
β-strand	64	1	60
β-strand	72-74	3	61
β-strand	81-82	2	62
α-helix	85-97	13
β-strand	101-106	6	63
β-strand	109-110	2	62
α-helix	112-119	8
β-strand	126-131	6	63
α-helix	133-136	4
β-strand	147-150	4	25
α-helix	151-152	2
α-helix	153-163	11
β-strand	172-173	2	25
α-helix	178-183	6
β-strand	190-197	8	25
β-strand	201-209	9	25

Chain F: 3 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	56-57	2	64
α-helix	59-74	16
α-helix	77-78	2
β-strand	79	1	27
α-helix	89-98	10
β-strand	104-109	6	26
β-strand	115-119	5	26
β-strand	124-125	2	64

Chain G: 3 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	3-13	11	26
α-helix	15-17	3
α-helix	23-34	12
β-strand	44-54	11	26
β-strand	58-59	2	26
α-helix	60	1
β-strand	66-77	12	26
β-strand	84-92	9	65
β-strand	97-101	5	65
β-strand	104-108	5	65
β-strand	117-120	4	66
β-strand	127-130	4	66
β-strand	137-138	2	66
β-strand	142-152	11	65
β-strand	157-162	6	65
β-strand	169-170	2	65

Chain H: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-14	11	13
β-strand	25-32	8	13
β-strand	38-44	7	13
β-strand	55-61	7	13
β-strand	90-101	12	13
β-strand	112-118	7	13
β-strand	121-127	7	13
α-helix	129-132	4
β-strand	140-147	8	13

7 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1984	Sus scrofa	A0A7M4DUC2
DNA-directed RNA polymerase subunit beta	B	protein	1300	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	I3LCH3 (AlphaFold model)
RNA polymerase II subunit D	D	protein	184	Sus scrofa	A0A287ADR4 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A4X1VYD0
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Sus scrofa	F1RKE4
RNA polymerase II subunit K	L	protein	58	Sus scrofa	A0A4X1TRS6

6 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>8S54_1 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPT
SPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSY
SPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTS
PKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDS
DEEN

Sequence of entity 2 (B), FASTA

>8S54_2 DNA-directed RNA polymerase subunit beta (chains B)
MKPLRPENPPKAELKGLLFVQQHCKTRLHSVAVTRPRGAATEESTPKLRMCSTNLSQALA
YFRAGANLTAASLWAGFRGSRRIFWERRKRKSLCLALRPGGACWRWLLAVSCVSLRGLGA
PGSCANMYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMS
VQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEAR
LRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCEL
NECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTST
IWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFED
PEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVS
DFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKE
VRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLT
FASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISV
GSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQM
DIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQ
DLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFP
DHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPA
GINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTR
ETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCST
FLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDM
PFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNL
LSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQP
MEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHT
YECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>8S54_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>8S54_4 RNA polymerase II subunit D (chains D)
MWGPAQPYSDSALSPKPRPFRAVFRGSALPFPAVRVEVRGRSMAAGGSDPRAGDVEEDAS
QLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRE
TIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKR
SFQY

Sequence of entity 5 (E), FASTA

>8S54_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>8S54_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>8S54_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>8S54_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>8S54_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>8S54_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>8S54_11 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>8S54_12 RNA polymerase II subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	9

Primary citation

Three-step mechanism of promoter escape by RNA polymerase II. Zhan, Y., Grabbe, F., Oberbeckmann, E. et al. Mol Cell (2024) 84:1699-1710.e6. DOI 10.1016/j.molcel.2024.03.016 · PubMed

Other PDB entries of the same protein (UniProt A0A7M4DUC2), best resolution first:

9BZ0 1.9 Å, Structure of an STK19-containing TC-NER complex
8S52 2.9 Å, RNA polymerase II core initially transcribing complex with an ordered RNA of 10 nt
9EGX 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27
9EGY 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27
9EGZ 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27
7UNC 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome
7UND 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38)
8A40 3.0 Å, Structure of mammalian Pol II-TFIIS elongation complex
6TED 3.1 Å, Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers…
9EH2 3.1 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream
8A3Y 3.3 Å, Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex
9ER2 3.3 Å, PolII-TCR-STK19 structure.

Browse structure collections

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