8S5N: DNA-directed RNA polymerase subunit

RNA polymerase II core initially transcribing complex with an ordered RNA of 12 nt. Determined by electron microscopy at 3.4 Å resolution. Released 10 Apr 2024.

Method: Electron microscopy
Resolution: 3.4 Å
Organisms: Sus scrofa, Homo sapiens, unidentified adenovirus
Chains: 23
Atoms: 44,716
Mol. weight: 923.62 kDa
Ligands: ZN, MG
Released: 10 Apr 2024

Explore 8S5N in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8S5N contains 237 α-helices and 289 β-strands across 20 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 77 helices, 67 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	1
β-strand	20-24	5	2
α-helix	25-27	3
α-helix	28-34	7
β-strand	47-48	2	3
β-strand	51-52	2	3
α-helix	78-80	3
β-strand	88-94	7	4
α-helix	100-107	8
β-strand	110	1	5
β-strand	117	1	5
α-helix	125-129	5
α-helix	137-145	9
α-helix	188-189	2
β-strand	190-191	2	6
β-strand	199-201	3	6
β-strand	213-215	3	6
α-helix	218-226	9
α-helix	230-236	7
α-helix	245-248	4
β-strand	250-253	4	4
α-helix	262-263	2
β-strand	264	1	7
α-helix	265	1
β-strand	272	1	7
α-helix	273-274	2
α-helix	275-296	22
α-helix	300-318	19
α-helix	326-327	2
β-strand	328-329	2	8
β-strand	335	1	8
α-helix	340-343	4
α-helix	349-350	2
α-helix	351-355	5
β-strand	357-358	2	9
β-strand	362-369	8	10
β-strand	377-380	4	10
α-helix	382-387	6
β-strand	389-393	5	11
α-helix	399-408	10
β-strand	416-420	5	11
β-strand	426-427	2	11
β-strand	445-449	5	11
α-helix	450	1
β-strand	455-459	5	10
α-helix	466-468	3
β-strand	469-476	8	10
β-strand	482-484	3	10
α-helix	489-492	4
β-strand	500-504	5	10
α-helix	509-518	10
β-strand	520	1	10
β-strand	526-527	2	12
β-strand	532-533	2	12
α-helix	539-548	10
β-strand	554-555	2	13
α-helix	557-563	7
α-helix	564-566	3
α-helix	574	1
β-strand	575	1	14
α-helix	576-577	2
β-strand	579	1	15
β-strand	585	1	15
β-strand	586-587	2	13
α-helix	588-595	8
β-strand	604-605	2	16
α-helix	613-615	3
β-strand	627-628	2	16
α-helix	642-645	4
α-helix	652-660	9
α-helix	663-683	21
β-strand	686	1	17
α-helix	689-691	3
α-helix	696-721	26
α-helix	726-728	3
α-helix	733-758	26
α-helix	765-770	6
α-helix	778-784	7
β-strand	789-790	2	18
β-strand	793	1	19
β-strand	796	1	19
β-strand	822-823	2	18
α-helix	833-867	35
β-strand	872-873	2	20
β-strand	879-880	2	20
β-strand	886-888	3	20
α-helix	891-893	3
β-strand	896	1	21
β-strand	902-903	2	22
α-helix	913-920	8
α-helix	927-933	7
β-strand	934	1	23
α-helix	936-944	9
α-helix	946-969	24
β-strand	978-979	2	22
α-helix	983-993	11
β-strand	1002	1	23
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1053	3
α-helix	1054-1058	5
α-helix	1062-1078	17
β-strand	1080	1	21
α-helix	1081-1082	2
α-helix	1087-1096	10
α-helix	1097-1099	3
α-helix	1121-1128	8
β-strand	1140-1142	3	24
α-helix	1146-1148	3
α-helix	1151-1161	11
β-strand	1164	1	25
α-helix	1166-1169	4
β-strand	1170-1174	5	26
β-strand	1177	1	27
α-helix	1193-1196	4
β-strand	1210	1	27
β-strand	1212	1	28
β-strand	1213-1216	4	26
α-helix	1218-1223	6
α-helix	1228-1236	9
β-strand	1259	1	28
α-helix	1263-1265	3
α-helix	1284-1291	8
β-strand	1299	1	25
β-strand	1307	1	29
α-helix	1310-1312	3
β-strand	1319-1322	4	30
β-strand	1328-1331	4	30
β-strand	1335-1337	3	24
β-strand	1338	1	29
α-helix	1343-1347	5
α-helix	1362-1369	8
α-helix	1372-1385	14
α-helix	1391-1394	4
α-helix	1398-1405	8
β-strand	1408	1	31
α-helix	1411-1413	3
α-helix	1416-1419	4
α-helix	1426-1432	7
α-helix	1435-1445	11
β-strand	1448-1449	2	2
α-helix	1454-1459	6
β-strand	1473-1475	3	32

Chain B: 53 helices, 82 β-strands

Element	Residues	Length	Sheet
α-helix	22-36	15
α-helix	42-51	10
α-helix	55-61	7
α-helix	63-64	2
β-strand	65-66	2	33
β-strand	83-94	12	33
β-strand	97-99	3	34
β-strand	105-107	3	34
α-helix	110-115	6
β-strand	121-133	13	33
β-strand	142-153	12	33
α-helix	154-155	2
α-helix	168-173	6
β-strand	185-187	3	35
β-strand	190-194	5	35
β-strand	196-200	5	36
α-helix	201	1
β-strand	208-209	2	37
β-strand	215-218	4	37
β-strand	223	1	38
β-strand	233	1	38
β-strand	238-240	3	37
β-strand	256-258	3	37
β-strand	267-268	2	37
α-helix	269-275	7
α-helix	281-288	8
α-helix	296-306	11
α-helix	314-323	10
α-helix	332-345	14
α-helix	359-377	19
α-helix	381-383	3
α-helix	388-390	3
β-strand	391-394	4	36
α-helix	396-421	26
α-helix	431-434	4
α-helix	438-450	13
β-strand	453	1	39
β-strand	463	1	39
β-strand	467-469	3	35
β-strand	472	1	40
β-strand	474	1	40
α-helix	475-482	8
β-strand	484-486	3	36
α-helix	501-502	2
β-strand	509	1	41
α-helix	517-519	3
β-strand	520	1	36
β-strand	523-525	3	36
β-strand	526	1	41
β-strand	531-532	2	42
α-helix	533	1
α-helix	539-547	9
α-helix	550	1
β-strand	551-552	2	43
α-helix	558-560	3
β-strand	565-569	5	43
β-strand	572-577	6	43
α-helix	580-593	14
β-strand	606	1	43
β-strand	611-613	3	43
β-strand	621-627	7	42
β-strand	628	1	44
β-strand	633	1	44
α-helix	637-643	7
α-helix	653-658	6
β-strand	662-666	5	42
α-helix	669-672	4
β-strand	675-676	2	42
β-strand	695-696	2	42
α-helix	700-703	4
α-helix	714-716	3
α-helix	719-728	10
β-strand	732	1	45
β-strand	747-751	5	46
β-strand	755	1	47
β-strand	759-760	2	48
α-helix	762-765	4
β-strand	776-782	7	49
β-strand	783	1	17
β-strand	793-797	5	49
α-helix	798-802	5
β-strand	808-817	10	46
β-strand	827-829	3	50
β-strand	839	1	50
β-strand	848	1	51
β-strand	853	1	52
β-strand	854	1	51
α-helix	855	1
β-strand	859-860	2	46
β-strand	865	1	53
β-strand	867	1	52
β-strand	869-872	4	50
α-helix	873	1
β-strand	889-891	3	50
α-helix	893-894	2
β-strand	895	1	53
α-helix	896-897	2
β-strand	902-911	10	46
β-strand	917-927	11	46
β-strand	934-937	4	49
β-strand	944-949	6	49
β-strand	956	1	54
α-helix	961-963	3
β-strand	965-967	3	49
α-helix	969-971	3
α-helix	978-993	16
α-helix	996	1
β-strand	997-998	2	48
α-helix	1008-1016	9
β-strand	1025-1026	2	49
β-strand	1029	1	54
α-helix	1035	1
β-strand	1036	1	54
α-helix	1037	1
β-strand	1041-1050	10	49
β-strand	1051	1	45
α-helix	1055-1057	3
β-strand	1060-1061	2	10
β-strand	1067	1	55
β-strand	1074	1	55
α-helix	1075	1
α-helix	1078-1080	3
β-strand	1085-1086	2	9
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1115-1119	5	1
β-strand	1125	1	1
β-strand	1127	1	56
β-strand	1136	1	56
β-strand	1137	1	57
β-strand	1142	1	57
β-strand	1146-1150	5	1
α-helix	1153-1164	12
β-strand	1168-1172	5	2

Chain C: 10 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	8-11	4	58
β-strand	18	1	59
β-strand	21-24	4	58
α-helix	28-39	12
β-strand	44-55	12	60
α-helix	61-69	9
β-strand	73	1	61
α-helix	78-81	4
α-helix	95-97	3
β-strand	99-107	9	60
β-strand	113-116	4	62
α-helix	117-119	3
β-strand	121-122	2	60
β-strand	129	1	61
β-strand	149-153	5	62
β-strand	157-168	12	60
α-helix	174-176	3
β-strand	179	1	63
β-strand	184-185	2	58
α-helix	200-202	3
α-helix	204-205	2
α-helix	218-220	3
β-strand	229-231	3	58
β-strand	234	1	59
β-strand	235	1	63
α-helix	241-268	28

Chain D: 13 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	64
α-helix	17-19	3
β-strand	21	1	64
α-helix	24-26	3
α-helix	29	1
β-strand	30	1	32
α-helix	31	1
α-helix	34-49	16
α-helix	55-57	3
α-helix	59-70	12
α-helix	77-89	13
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14
α-helix	139-140	2

Chain E: 11 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	3-23	21
β-strand	26-27	2	65
α-helix	30-33	4
α-helix	37-43	7
α-helix	55-57	3
β-strand	62-64	3	65
β-strand	71-72	2	65
β-strand	81-82	2	66
α-helix	84-95	12
β-strand	103-106	4	67
β-strand	109-110	2	66
α-helix	112-121	10
β-strand	128-131	4	67
α-helix	133-135	3
α-helix	139-141	3
β-strand	147-150	4	31
α-helix	153-159	7
α-helix	171	1
β-strand	172-173	2	31
α-helix	178-183	6
β-strand	190-195	6	31
β-strand	203-209	7	31

Chain F: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	59-74	16
α-helix	77-79	3
α-helix	89-99	11
β-strand	105-109	5	32
β-strand	115-119	5	32

Chain G: 2 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	2-13	12	32
α-helix	15-17	3
α-helix	22-34	13
β-strand	39	1	68
β-strand	43	1	68
β-strand	44-54	11	32
β-strand	57-59	3	32
β-strand	66-77	12	32
β-strand	84-92	9	69
β-strand	97-101	5	69
β-strand	104-108	5	69
β-strand	118-119	2	70
β-strand	127-129	3	70
β-strand	137-138	2	70
β-strand	142-146	5	69
β-strand	150-152	3	69
β-strand	157-161	5	69

Chain H: 2 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	4-14	11	71
β-strand	25-31	7	71
β-strand	38-44	7	71
β-strand	55-61	7	71
β-strand	74	1	14
α-helix	84-87	4
β-strand	90-91	2	71
β-strand	92	1	15
β-strand	94-101	8	71
β-strand	111-118	8	71
β-strand	121-128	8	71
α-helix	129-131	3
β-strand	140-145	6	71
β-strand	147-148	2	71

12 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1984	Sus scrofa	A0A7M4DUC2
DNA-directed RNA polymerase subunit beta	B	protein	1300	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	I3LCH3 (AlphaFold model)
RNA polymerase II subunit D	D	protein	184	Sus scrofa	A0A287ADR4 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A8W4F9W9
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Sus scrofa	F1RKE4
RNA polymerase II subunit K	L	protein	58	Sus scrofa	A0A4X1TRS6

11 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>8S5N_1 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPT
SPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSY
SPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTS
PKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDS
DEEN

Sequence of entity 2 (B), FASTA

>8S5N_2 DNA-directed RNA polymerase subunit beta (chains B)
MKPLRPENPPKAELKGLLFVQQHCKTRLHSVAVTRPRGAATEESTPKLRMCSTNLSQALA
YFRAGANLTAASLWAGFRGSRRIFWERRKRKSLCLALRPGGACWRWLLAVSCVSLRGLGA
PGSCANMYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMS
VQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEAR
LRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCEL
NECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTST
IWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFED
PEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVS
DFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKE
VRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLT
FASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISV
GSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQM
DIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQ
DLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFP
DHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPA
GINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTR
ETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCST
FLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDM
PFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNL
LSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQP
MEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHT
YECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>8S5N_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>8S5N_4 RNA polymerase II subunit D (chains D)
MWGPAQPYSDSALSPKPRPFRAVFRGSALPFPAVRVEVRGRSMAAGGSDPRAGDVEEDAS
QLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRE
TIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKR
SFQY

Sequence of entity 5 (E), FASTA

>8S5N_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>8S5N_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>8S5N_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>8S5N_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>8S5N_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>8S5N_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>8S5N_11 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>8S5N_12 RNA polymerase II subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	10
MG	Magnesium ion	Mg	1

Primary citation

Three-step mechanism of promoter escape by RNA polymerase II. Zhan, Y., Grabbe, F., Oberbeckmann, E. et al. Mol Cell (2024) 84:1699-1710.e6. DOI 10.1016/j.molcel.2024.03.016 · PubMed

Other PDB entries of the same protein (UniProt A0A7M4DUC2), best resolution first:

9BZ0 1.9 Å, Structure of an STK19-containing TC-NER complex
8S52 2.9 Å, RNA polymerase II core initially transcribing complex with an ordered RNA of 10 nt
9EGX 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27
9EGY 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27
9EGZ 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27
7UNC 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome
7UND 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38)
8A40 3.0 Å, Structure of mammalian Pol II-TFIIS elongation complex
6TED 3.1 Å, Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers…
9EH2 3.1 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream
8A3Y 3.3 Å, Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex
9ER2 3.3 Å, PolII-TCR-STK19 structure.

Browse structure collections

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