8TAU: APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB. Determined by electron microscopy at 3.5 Å resolution. Released 27 Sept 2023.
- Method
- Electron microscopy
- Resolution
- 3.5 Å
- Organism
- Homo sapiens
- Chains
- 23
- Atoms
- 36,019
- Mol. weight
- 1239.32 kDa
- Ligands
- ZN
- Released
- 27 Sept 2023
Explore 8TAU in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8TAU contains 528 α-helices and 170 β-strands across 23 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 103 helices, 58 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 12-13 | 2 | 1 |
| β-strand | 18-19 | 2 | 2 |
| α-helix | 24-28 | 5 | |
| α-helix | 42-46 | 5 | |
| β-strand | 72-78 | 7 | 3 |
| β-strand | 90-96 | 7 | 3 |
| β-strand | 99-107 | 9 | 3 |
| β-strand | 110-118 | 9 | 3 |
| β-strand | 125-132 | 8 | 4 |
| α-helix | 144-146 | 3 | |
| β-strand | 147-155 | 9 | 4 |
| β-strand | 158-163 | 6 | 4 |
| β-strand | 168-172 | 5 | 4 |
| β-strand | 177-182 | 6 | 5 |
| β-strand | 187-191 | 5 | 5 |
| α-helix | 192-193 | 2 | |
| α-helix | 206-208 | 3 | |
| β-strand | 210-213 | 4 | 5 |
| α-helix | 219-220 | 2 | |
| β-strand | 221-222 | 2 | 5 |
| β-strand | 224-226 | 3 | 6 |
| β-strand | 236-238 | 3 | 6 |
| β-strand | 244-249 | 6 | 6 |
| β-strand | 255-260 | 6 | 6 |
| β-strand | 265-273 | 9 | 6 |
| α-helix | 274-275 | 2 | |
| α-helix | 276-282 | 7 | |
| α-helix | 400-404 | 5 | |
| β-strand | 407-414 | 8 | 6 |
| β-strand | 429-431 | 3 | 7 |
| β-strand | 441-446 | 6 | 7 |
| α-helix | 447-449 | 3 | |
| β-strand | 451-459 | 9 | 7 |
| β-strand | 466-475 | 10 | 7 |
| β-strand | 478-482 | 5 | 8 |
| β-strand | 487-491 | 5 | 8 |
| β-strand | 497-501 | 5 | 8 |
| β-strand | 504-508 | 5 | 8 |
| β-strand | 509-510 | 2 | 1 |
| α-helix | 511 | 1 | |
| β-strand | 584-591 | 8 | 2 |
| β-strand | 594-599 | 6 | 2 |
| β-strand | 604-608 | 5 | 2 |
| α-helix | 609-611 | 3 | |
| α-helix | 616-628 | 13 | |
| α-helix | 631-645 | 15 | |
| α-helix | 656-667 | 12 | |
| α-helix | 676-680 | 5 | |
| α-helix | 704-712 | 9 | |
| α-helix | 714-719 | 6 | |
| α-helix | 725-728 | 4 | |
| α-helix | 730-732 | 3 | |
| β-strand | 747-748 | 2 | 9 |
| α-helix | 756-758 | 3 | |
| α-helix | 759-774 | 16 | |
| α-helix | 777-779 | 3 | |
| α-helix | 781-783 | 3 | |
| α-helix | 786-796 | 11 | |
| α-helix | 801-807 | 7 | |
| α-helix | 811-813 | 3 | |
| β-strand | 821-822 | 2 | 9 |
| α-helix | 827-830 | 4 | |
| α-helix | 844-852 | 9 | |
| α-helix | 857-859 | 3 | |
| β-strand | 860-862 | 3 | 10 |
| α-helix | 869-877 | 9 | |
| α-helix | 878-882 | 5 | |
| β-strand | 896-898 | 3 | 10 |
| α-helix | 923-925 | 3 | |
| α-helix | 926-936 | 11 | |
| α-helix | 941-946 | 6 | |
| α-helix | 952-962 | 11 | |
| α-helix | 972-977 | 6 | |
| α-helix | 1012-1013 | 2 | |
| α-helix | 1021-1027 | 7 | |
| α-helix | 1033-1039 | 7 | |
| α-helix | 1046 | 1 | |
| β-strand | 1047-1048 | 2 | 11 |
| α-helix | 1059-1077 | 19 | |
| α-helix | 1081-1087 | 7 | |
| β-strand | 1092 | 1 | 12 |
| β-strand | 1108-1111 | 4 | 11 |
| α-helix | 1112-1114 | 3 | |
| β-strand | 1116-1119 | 4 | 11 |
| α-helix | 1123-1125 | 3 | |
| α-helix | 1132-1144 | 13 | |
| β-strand | 1147 | 1 | 12 |
| α-helix | 1155-1160 | 6 | |
| α-helix | 1166-1168 | 3 | |
| α-helix | 1169-1181 | 13 | |
| α-helix | 1184-1187 | 4 | |
| α-helix | 1190-1198 | 9 | |
| α-helix | 1202-1214 | 13 | |
| α-helix | 1222-1229 | 8 | |
| α-helix | 1233-1235 | 3 | |
| α-helix | 1237-1238 | 2 | |
| α-helix | 1247-1260 | 14 | |
| α-helix | 1267-1277 | 11 | |
| α-helix | 1291-1306 | 16 | |
| α-helix | 1321-1330 | 10 | |
| β-strand | 1333 | 1 | 13 |
| α-helix | 1347-1349 | 3 | |
| β-strand | 1352-1353 | 2 | 14 |
| β-strand | 1357 | 1 | 13 |
| α-helix | 1360-1374 | 15 | |
| α-helix | 1381-1386 | 6 | |
| α-helix | 1389-1390 | 2 | |
| α-helix | 1393-1396 | 4 | |
| α-helix | 1401-1413 | 13 | |
| α-helix | 1416-1418 | 3 | |
| α-helix | 1423-1428 | 6 | |
| α-helix | 1432-1441 | 10 | |
| α-helix | 1454-1475 | 22 | |
| β-strand | 1481 | 1 | 15 |
| α-helix | 1482-1500 | 19 | |
| α-helix | 1504-1507 | 4 | |
| α-helix | 1509-1526 | 18 | |
| α-helix | 1533-1544 | 12 | |
| α-helix | 1552-1565 | 14 | |
| α-helix | 1567-1570 | 4 | |
| β-strand | 1572-1573 | 2 | 16 |
| α-helix | 1578-1587 | 10 | |
| α-helix | 1604-1612 | 9 | |
| β-strand | 1615-1616 | 2 | 16 |
| β-strand | 1618 | 1 | 17 |
| β-strand | 1621-1623 | 3 | 18 |
| β-strand | 1628-1629 | 2 | 18 |
| β-strand | 1633-1638 | 6 | 19 |
| α-helix | 1639-1640 | 2 | |
| β-strand | 1647-1652 | 6 | 19 |
| β-strand | 1656 | 1 | 17 |
| α-helix | 1657-1659 | 3 | |
| α-helix | 1660-1662 | 3 | |
| β-strand | 1663-1669 | 7 | 19 |
| β-strand | 1673 | 1 | 20 |
| β-strand | 1676-1679 | 4 | 19 |
| α-helix | 1680-1682 | 3 | |
| α-helix | 1685-1692 | 8 | |
| β-strand | 1697-1699 | 3 | 18 |
| β-strand | 1701 | 1 | 20 |
| α-helix | 1702 | 1 | |
| α-helix | 1726-1732 | 7 | |
| α-helix | 1735-1741 | 7 | |
| α-helix | 1745-1750 | 6 | |
| α-helix | 1751-1755 | 5 | |
| α-helix | 1762-1764 | 3 | |
| α-helix | 1765-1780 | 16 | |
| α-helix | 1784-1786 | 3 | |
| α-helix | 1787-1800 | 14 | |
| α-helix | 1809-1821 | 13 | |
| α-helix | 1826-1829 | 4 | |
| α-helix | 1830-1832 | 3 | |
| α-helix | 1844-1859 | 16 | |
| α-helix | 1860-1864 | 5 | |
| α-helix | 1865-1873 | 9 | |
| α-helix | 1882-1891 | 10 | |
| α-helix | 1894-1896 | 3 | |
| α-helix | 1897-1899 | 3 | |
| α-helix | 1905-1907 | 3 | |
| α-helix | 1911-1916 | 6 | |
| α-helix | 1925-1935 | 11 | |
Chain B: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 43-45 | 3 | |
Chain C: 2 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-7 | 6 | 21 |
| β-strand | 10-12 | 3 | 22 |
| β-strand | 22-23 | 2 | 23 |
| β-strand | 28-29 | 2 | 23 |
| α-helix | 33-34 | 2 | |
| β-strand | 46-48 | 3 | 24 |
| β-strand | 49 | 1 | 25 |
| β-strand | 54-56 | 3 | 24 |
| α-helix | 57-66 | 10 | |
| β-strand | 72 | 1 | 26 |
| β-strand | 79 | 1 | 26 |
| β-strand | 82 | 1 | 25 |
Chain D: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-7 | 3 | |
| α-helix | 9-11 | 3 | |
| α-helix | 15-17 | 3 | |
| α-helix | 26-45 | 20 | |
| α-helix | 51-53 | 3 | |
Chain E: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 2-13 | 12 | |
| α-helix | 14-16 | 3 | |
Chain G: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-8 | 5 | |
| α-helix | 13-16 | 4 | |
| α-helix | 17-25 | 9 | |
Chain H: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 52-83 | 32 | |
| α-helix | 85-91 | 7 | |
| α-helix | 93-95 | 3 | |
| α-helix | 99-102 | 4 | |
Chain I: 27 helices, 33 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 12-18 | 7 | 27 |
| β-strand | 23-28 | 6 | 28 |
| β-strand | 35-39 | 5 | 28 |
| β-strand | 43-47 | 5 | 28 |
| β-strand | 54-58 | 5 | 28 |
| α-helix | 59-60 | 2 | |
| β-strand | 68-73 | 6 | 29 |
| β-strand | 80-84 | 5 | 29 |
| β-strand | 89-94 | 6 | 29 |
| β-strand | 99-105 | 7 | 29 |
| β-strand | 110-115 | 6 | 30 |
| α-helix | 120-122 | 3 | |
| α-helix | 142-144 | 3 | |
| α-helix | 148-152 | 5 | |
| α-helix | 161-169 | 9 | |
| α-helix | 173 | 1 | |
| β-strand | 176-180 | 5 | 30 |
| β-strand | 184-188 | 5 | 30 |
| β-strand | 194-199 | 6 | 30 |
| β-strand | 204-210 | 7 | 31 |
| β-strand | 216-222 | 7 | 31 |
| β-strand | 230-237 | 8 | 31 |
| α-helix | 239-243 | 5 | |
| α-helix | 245-272 | 28 | |
| α-helix | 278-293 | 16 | |
| α-helix | 300-308 | 9 | |
| α-helix | 315-319 | 5 | |
| α-helix | 320-324 | 5 | |
| α-helix | 327-347 | 21 | |
| α-helix | 348-352 | 5 | |
| α-helix | 353-370 | 18 | |
| α-helix | 373-376 | 4 | |
| α-helix | 377-379 | 3 | |
| α-helix | 383-428 | 46 | |
| α-helix | 442-455 | 14 | |
| α-helix | 476-479 | 4 | |
| β-strand | 485 | 1 | 32 |
| α-helix | 496-503 | 8 | |
| α-helix | 514-516 | 3 | |
| β-strand | 520 | 1 | 32 |
| α-helix | 522-546 | 25 | |
| β-strand | 550-552 | 3 | 31 |
| β-strand | 555-558 | 4 | 31 |
| β-strand | 583-592 | 10 | 33 |
| β-strand | 595-604 | 10 | 33 |
| β-strand | 616-619 | 4 | 33 |
| β-strand | 623 | 1 | 34 |
| β-strand | 636-643 | 8 | 35 |
| β-strand | 648-655 | 8 | 35 |
| α-helix | 660-662 | 3 | |
| β-strand | 664-670 | 7 | 35 |
| α-helix | 671-674 | 4 | |
| α-helix | 694-696 | 3 | |
| β-strand | 702-704 | 3 | 33 |
| β-strand | 707 | 1 | 34 |
| β-strand | 711-713 | 3 | 35 |
| α-helix | 715-717 | 3 | |
| β-strand | 719-725 | 7 | 27 |
| β-strand | 730-735 | 6 | 27 |
| β-strand | 740-745 | 6 | 27 |
15 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Anaphase-promoting complex subunit 1 | A | protein | 1944 | Homo sapiens | Q9H1A4 (AlphaFold model) |
| G2/mitotic-specific cyclin-B1 | B | protein | 12 | Homo sapiens | P14635 (AlphaFold model) |
| Anaphase-promoting complex subunit 11 | C | protein | 84 | Homo sapiens | Q9NYG5 (AlphaFold model) |
| Anaphase-promoting complex subunit 15 | D | protein | 56 | Homo sapiens | P60006 (AlphaFold model) |
| Ubiquitin-conjugating enzyme E2 S | E | protein | 18 | Homo sapiens | Q16763 |
| Anaphase-promoting complex subunit CDC26 | G, W | protein | 85 | Homo sapiens | Q8NHZ8 |
| Anaphase-promoting complex subunit 16 | H | protein | 110 | Homo sapiens | Q96DE5 |
| Anaphase-promoting complex subunit 4 | I | protein | 808 | Homo sapiens | Q9UJX5 |
| Cell division cycle protein 27 homolog | J, P | protein | 824 | Homo sapiens | P30260 |
| Cell division cycle protein 16 homolog | K, S | protein | 620 | Homo sapiens | Q13042 |
| Anaphase-promoting complex subunit 10 | L | protein | 185 | Homo sapiens | Q9UM13 |
| Anaphase-promoting complex subunit 13 | M | protein | 74 | Homo sapiens | Q9BS18 |
6 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>8TAU_1 Anaphase-promoting complex subunit 1 (chains A)
MSNFYEERTTMIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGS
LQEVTIHEKQKESWQLRKGVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVD
SPVQQALWCDFIISQDKSEKAYSSNEVEKCICILQSSCINMHSIEGKDYIASLPFQVANV
WPTKYGLLFERSASSHEVPPGEPREPLPTMFSMLHPLDEITPLVCKSGSLFGSSRVQYVV
DHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKSEEENVVLKFEEQGGEPQNVATSSS
LTAHLRSLSKGDEPVEEPFQNYSSIHSQSRSTSEPSLHSREPEISNMAALSRAHEPALGV
HEFSGVQRFNIESHNQEPKRHSISHSPNSNSNGSFLAPETEPIVPELCIDHLWTETITNI
REKNSQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQESNDKTQLIFGSVTNIPAKDAA
PVEKIDTMLVLEGSGNLVLYTGVVRVGKVFIPGLPAPSLTMSNTMPRPSTPLDGVSEPKP
LSKLLGELDEVVLLEPVPELRDSSKLHDELYNEDCTFQQLGTYIHSIRDPVHNRVTLELS
NGSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLF
VTCLMNMMGYNTDRLAWTRNFDFEGSLEPVIAPKKARPEETGSDDDWEYLLNSDYHQNVE
SHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMG
EGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSE
PPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRIT
IAPQKLQVEQEENRFEFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIY
HCREQPASDWPEAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMN
HEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHEFIEEKENRLLQLCQRTMAL
PVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNG
VAAGLKIAPASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKG
HEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLV
YQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLN
VPEQLYQYMVGGHRRFQTGMHREKHKEPSYQIKEGDTINVDVTCPGATLALAMIYLKTNN
RSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENSIS
LSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLS
APNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHM
ALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRYHLQALRHLYVLAAEPRLLV
PVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDL
SKGTQHLKSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISA
FTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRL
GRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWL
QVGGDMCVHAYLSGQPLEESQLSMLACFLVYHSVPAPQHLPPIGLEGSTSFAELLFKFKQ
LKMPVRALLRLAPLLLGNPQPMVM
Sequence of entity 2 (B), FASTA
>8TAU_2 G2/mitotic-specific cyclin-B1 (chains B)
LRPRTALGDIGN
Sequence of entity 3 (C), FASTA
>8TAU_3 Anaphase-promoting complex subunit 11 (chains C)
MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCI
LKWLHAQQVQQHCPMCRQEWKFKE
Sequence of entity 4 (D), FASTA
>8TAU_4 Anaphase-promoting complex subunit 15 (chains D)
STLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKP
Sequence of entity 5 (E), FASTA
>8TAU_5 Ubiquitin-conjugating enzyme E2 S (chains E)
KKLAAKKKTDKKRALRRL
Sequence of entity 6 (G, W), FASTA
>8TAU_6 Anaphase-promoting complex subunit CDC26 (chains G, W)
MLRRKPTRLELKLDDIEEFENIRKDLETRKKQKEDVEVVGGSDGEGAIGLEEDPKSREQM
INDRIGYKPQPKPNNRSSQFGELEF
Sequence of entity 7 (H), FASTA
>8TAU_7 Anaphase-promoting complex subunit 16 (chains H)
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFS
YQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPSSG
Sequence of entity 8 (I), FASTA
>8TAU_8 Anaphase-promoting complex subunit 4 (chains I)
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPP
NENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTV
ESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNL
LYSFLPEVTRMARKFTHISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKNTTTSV
QDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRW
LYVAMLRMTEDHVLPELNKMTQKDITFVAEFLTEHFNEAPDLYNRKGKYFNVERVGQYLK
DEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCI
LRRHTDISQSVSNGLIAIKFGSFTYATTEKVRRSIYSCLDAQFYDDETVTVVLKDTVGRE
GRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ
YVAGNGFRKVSCVLSSNLRHVRVFEMDIDDEWELDESSDEEEEASNKPVKIKEEVLEEEE
AENQQAGAAALAPEIVIKVEKLDPELDS
Sequence of entity 9 (J, P), FASTA
>8TAU_9 Cell division cycle protein 27 homolog (chains J, P)
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL
LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL
LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL
PNSCTTQVPNHSLSHRQPEEVLTEEPQDTIELNRLNLESENSKYSLNTDSSVSYIDSAVI
EPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALEPLTPSFGILPLETPSPGDGSYLQN
YTNTPPVIDVPSTGAPSKKEVARIGQTGTKSVFSQEGNEREVTPILAQTQSSGPQTSTTP
QVLSPTITSPPNALPRRSSRLFTSDEETTKENEKKLKMKFPPKIPNRKTKSKTNKGGITQ
PNINDELEITKLDSEIISEGKISTIEPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYN
CKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS
TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY
AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK
ALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYK
SALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAID
KRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
Sequence of entity 10 (K, S), FASTA
>8TAU_10 Cell division cycle protein 16 homolog (chains K, S)
MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL
RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDEEGFKDPSSD
WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE
EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAER
HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV
SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA
AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT
AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS
TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD
KLKCYDFDVHTMKTLKNIIEPPWDFREFEVEKQTAEETGLEPLEEERKTPDSRPSLEETF
EIEMNESDMMLETSMSDHST
Sequence of entity 11 (L), FASTA
>8TAU_11 Anaphase-promoting complex subunit 10 (chains L)
MTEPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQ
PHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWI
HVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGKFPRCTTIDFMM
YRSIR
Sequence of entity 12 (M), FASTA
>8TAU_12 Anaphase-promoting complex subunit 13 (chains M)
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDL
ALQYLHENVPPIGN
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 4 |
Primary citation
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Bodrug, T., Welsh, K.A., Bolhuis, D.L. et al. Nat Struct Mol Biol (2023) 30:1663-1674. DOI 10.1038/s41594-023-01105-5 · PubMed
Other PDB entries of the same protein (UniProt Q9H1A4 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5LGG 2.15 Å, The N-terminal WD40 domain of Apc1 (Anaphase promoting complex subunit 1)
- 9GAW 2.9 Å, High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to…
- 6Q6G 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class
- 6Q6H 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class
- 8PKP 3.2 Å, Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2…
- 5G05 3.4 Å, Cryo-EM structure of combined apo phosphorylated APC
- 4UI9 3.6 Å, Atomic structure of the human Anaphase-Promoting Complex
- 6TNT 3.78 Å, SUMOylated apoAPC/C with repositioned APC2 WHB domain
- 6TLJ 3.8 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the…
- 5G04 3.9 Å, Structure of the human APC-Cdc20-Hsl1 complex
- 6TM5 3.9 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A…
- 9N9R 3.9 Å, Model of APC/C-CDC20-UBE2C from H2A/H2B-bound complex
Browse structure collections
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