9G26: DNA-directed RNA polymerase I subunit RPA190

Yeast RNA polymerase I elongation complex stalled by an apurinic site, closed state. Determined by electron microscopy at 3.4 Å resolution. Released 18 Jun 2025.

Method: Electron microscopy
Resolution: 3.4 Å
Organism: Saccharomyces cerevisiae
Chains: 17
Atoms: 33,973
Mol. weight: 617.66 kDa
Ligands: ZN, MG
Released: 18 Jun 2025

Explore 9G26 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9G26 contains 179 α-helices and 255 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 77 helices, 65 β-strands

Element	Residues	Length	Sheet
β-strand	11-18	8	1
α-helix	21-27	7
β-strand	31	1	2
β-strand	38	1	3
β-strand	44	1	3
α-helix	52-54	3
α-helix	60-62	3
β-strand	77-86	10	2
α-helix	88-90	3
α-helix	91-98	8
β-strand	101-102	2	4
β-strand	107-108	2	4
α-helix	112-125	14
α-helix	130-135	6
α-helix	136-138	3
α-helix	175-199	25
α-helix	210-227	18
β-strand	243-245	3	5
β-strand	251-253	3	5
α-helix	258-267	10
β-strand	314	1	5
α-helix	317-330	14
α-helix	332-338	7
α-helix	352-355	4
β-strand	356-362	7	2
α-helix	365-368	4
β-strand	372-373	2	6
β-strand	376-377	2	6
α-helix	378-380	3
α-helix	381-403	23
α-helix	405-408	4
α-helix	413-438	26
α-helix	452-454	3
α-helix	457-459	3
α-helix	467	1
α-helix	468-472	5
β-strand	474-476	3	7
β-strand	479-486	8	8
β-strand	494-497	4	8
α-helix	499-502	4
β-strand	506-510	5	9
α-helix	516-525	10
β-strand	533-537	5	9
β-strand	543-545	3	9
α-helix	551-559	9
β-strand	576-580	5	9
α-helix	581	1
β-strand	586-590	5	8
α-helix	597-599	3
β-strand	600-607	8	8
β-strand	614-616	3	8
α-helix	620-624	5
β-strand	632-636	5	8
α-helix	641-649	9
β-strand	652	1	8
α-helix	653-656	4
β-strand	658	1	10
β-strand	665	1	10
α-helix	672-680	9
β-strand	686-688	3	11
α-helix	689-700	12
α-helix	702-704	3
β-strand	719-721	3	11
β-strand	725-727	3	11
α-helix	728-739	12
α-helix	741	1
β-strand	750-752	3	12
α-helix	757-760	4
β-strand	768-770	3	12
β-strand	771-772	2	13
β-strand	775-776	2	13
α-helix	783-785	3
α-helix	793-823	31
β-strand	826-827	2	14
α-helix	830-833	4
α-helix	837-848	12
α-helix	850-861	12
α-helix	864-865	2
α-helix	873-884	12
α-helix	886-911	26
α-helix	924-930	7
α-helix	937-944	8
β-strand	948-949	2	15
β-strand	952	1	16
β-strand	955	1	16
α-helix	970	1
β-strand	981-982	2	15
β-strand	985	1	17
β-strand	989	1	17
α-helix	992-1027	36
β-strand	1031-1032	2	18
β-strand	1038-1039	2	18
β-strand	1045-1047	3	18
β-strand	1055	1	19
α-helix	1066-1077	12
β-strand	1090	1	20
α-helix	1093-1108	16
α-helix	1123-1126	4
β-strand	1132	1	20
α-helix	1138-1148	11
α-helix	1163-1176	14
β-strand	1178	1	19
α-helix	1179-1180	2
α-helix	1185-1194	10
α-helix	1195-1199	5
α-helix	1219-1223	5
α-helix	1224-1228	5
β-strand	1238-1241	4	21
β-strand	1242	1	22
α-helix	1248-1258	11
β-strand	1261-1262	2	23
α-helix	1263-1266	4
β-strand	1267-1275	9	24
β-strand	1289-1296	8	24
α-helix	1299-1306	8
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1337	16
α-helix	1441-1453	13
β-strand	1457	1	25
β-strand	1461-1462	2	24
β-strand	1469-1471	3	24
β-strand	1474	1	25
α-helix	1487-1495	9
β-strand	1497-1499	3	23
β-strand	1507-1508	2	21
α-helix	1510-1512	3
β-strand	1518-1521	4	21
α-helix	1526-1531	6
β-strand	1536	1	22
α-helix	1538-1540	3
β-strand	1542-1543	2	21
α-helix	1547-1553	7
α-helix	1555-1570	16
α-helix	1581-1588	8
α-helix	1601-1603	3
α-helix	1609-1615	7
α-helix	1618-1626	9
β-strand	1631-1632	2	1
α-helix	1637-1643	7
β-strand	1654-1656	3	26
β-strand	1659	1	27

Chain B: 51 helices, 86 β-strands

Element	Residues	Length	Sheet
α-helix	18-26	9
α-helix	36-38	3
α-helix	39-52	14
α-helix	63-68	6
β-strand	71-73	3	28
β-strand	95-105	11	28
α-helix	106-107	2
β-strand	108-109	2	29
β-strand	119-120	2	29
β-strand	134	1	30
β-strand	136-144	9	28
β-strand	154-157	4	28
β-strand	162	1	30
α-helix	177-182	6
β-strand	195-196	2	31
β-strand	199-200	2	31
β-strand	201-203	3	32
β-strand	205-206	2	33
β-strand	207-209	3	34
α-helix	210	1
β-strand	211	1	35
β-strand	215-216	2	36
α-helix	220-222	3
β-strand	229	1	37
β-strand	234-236	3	36
β-strand	237	1	35
β-strand	239-240	2	38
β-strand	244-245	2	38
β-strand	248-252	5	36
β-strand	253	1	37
β-strand	258-264	7	36
β-strand	267-272	6	36
α-helix	273-280	8
α-helix	285-292	8
α-helix	301-316	16
α-helix	323-333	11
α-helix	346-355	10
α-helix	360-362	3
α-helix	367-385	19
α-helix	397-399	3
β-strand	400-402	3	34
α-helix	406-430	25
α-helix	431-435	5
α-helix	443-450	8
α-helix	457-467	11
α-helix	475-477	3
β-strand	485-487	3	32
α-helix	493-499	7
β-strand	503-504	2	33
α-helix	507-510	4
α-helix	515-517	3
α-helix	522-524	3
β-strand	528	1	39
β-strand	542	1	33
α-helix	544	1
β-strand	545	1	39
α-helix	546	1
β-strand	550-551	2	40
α-helix	561-567	7
β-strand	571-572	2	41
β-strand	584-588	5	41
β-strand	591-596	6	41
α-helix	598-613	16
β-strand	625-627	3	41
β-strand	641-643	3	41
β-strand	649-650	2	40
β-strand	651-655	5	42
β-strand	661-664	4	42
α-helix	666-669	4
β-strand	674-675	2	42
α-helix	678-680	3
β-strand	688-689	2	42
α-helix	693-696	4
α-helix	699-702	4
α-helix	707-709	3
β-strand	710	1	43
α-helix	712-722	11
β-strand	725	1	44
α-helix	733-735	3
β-strand	740-744	5	45
β-strand	748	1	46
β-strand	752-753	2	47
α-helix	756-759	4
β-strand	768-775	8	48
β-strand	776-777	2	14
β-strand	787-790	4	48
α-helix	791-795	5
β-strand	801-808	8	45
β-strand	823-825	3	49
α-helix	834-839	6
β-strand	840	1	50
β-strand	846	1	50
β-strand	851-852	2	45
β-strand	857-863	7	49
β-strand	868-873	6	49
β-strand	880-888	9	45
β-strand	900-908	9	45
β-strand	916-918	3	48
β-strand	924-931	8	48
β-strand	938-939	2	51
β-strand	947-949	3	48
α-helix	953-957	5
β-strand	959	1	43
α-helix	960-975	16
β-strand	979-980	2	47
α-helix	992-1001	10
β-strand	1010-1011	2	48
β-strand	1013-1014	2	51
β-strand	1021	1	51
α-helix	1022	1
β-strand	1026-1035	10	48
β-strand	1036	1	44
α-helix	1040-1042	3
β-strand	1045-1047	3	8
β-strand	1052	1	52
β-strand	1059	1	52
α-helix	1060	1
β-strand	1061	1	53
β-strand	1068	1	53
β-strand	1069-1071	3	7
α-helix	1073-1081	9
α-helix	1085-1089	5
α-helix	1090-1094	5
β-strand	1098-1099	2	54
β-strand	1102-1104	3	55
β-strand	1113-1115	3	56
α-helix	1116	1
β-strand	1117	1	57
α-helix	1118	1
β-strand	1126-1128	3	56
β-strand	1133-1134	2	57
β-strand	1158-1160	3	57
β-strand	1166-1168	3	57
β-strand	1173-1175	3	55
β-strand	1178-1179	2	54
α-helix	1180-1190	11
β-strand	1194-1200	7	1

Chain C: 13 helices, 23 β-strands

Element	Residues	Length	Sheet
α-helix	33-37	5
β-strand	41-42	2	58
β-strand	46	1	59
β-strand	51-52	2	60
β-strand	53	1	59
β-strand	55-57	3	58
α-helix	61-69	9
α-helix	70-74	5
β-strand	77-88	12	61
α-helix	94-103	10
β-strand	106	1	62
α-helix	110-112	3
β-strand	132-139	8	61
β-strand	141-142	2	63
α-helix	153-156	4
β-strand	157-158	2	63
β-strand	161-163	3	64
α-helix	164-166	3
β-strand	168-170	3	61
α-helix	173-177	5
β-strand	186	1	62
β-strand	192-195	4	64
β-strand	201-211	11	61
α-helix	217-219	3
β-strand	222-226	5	60
β-strand	229-231	3	58
β-strand	234-235	2	65
α-helix	242-250	9
β-strand	256-258	3	66
β-strand	265-267	3	66
α-helix	279-281	3
α-helix	283-285	3
β-strand	289-290	2	65
β-strand	293-299	7	58
β-strand	301-304	4	60
α-helix	310-330	21

Chain D: 6 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	15-17	3
β-strand	24	1	67
β-strand	29-30	2	68
α-helix	33-35	3
α-helix	36-41	6
α-helix	44-47	4
α-helix	82-84	3
α-helix	88-97	10

Chain E: 8 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	5-26	22
β-strand	28	1	69
α-helix	32-36	5
α-helix	39-45	7
β-strand	64	1	69
α-helix	66-69	4
β-strand	78-79	2	70
β-strand	82	1	70
α-helix	90-103	14
β-strand	107-112	6	70
α-helix	118-122	5
β-strand	131-136	6	70
β-strand	153-154	2	71
α-helix	158-168	11
β-strand	177-178	2	71
α-helix	183-188	6
β-strand	195-202	8	71
β-strand	206-214	9	71

Chain F: 5 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	55-72	18
β-strand	84-85	2	72
α-helix	86	1
α-helix	87-102	16
α-helix	117-127	11
β-strand	134-136	3	26
α-helix	148-150	3
β-strand	152-153	2	72

Chain G: 4 helices, 20 β-strands

Element	Residues	Length	Sheet
β-strand	39-40	2	68
β-strand	42-49	8	67
α-helix	51-53	3
α-helix	57-65	9
α-helix	67-69	3
β-strand	73	1	73
β-strand	80	1	73
β-strand	81	1	68
β-strand	88-89	2	67
β-strand	104	1	27
β-strand	106-107	2	67
α-helix	108	1
β-strand	114-121	8	67
β-strand	124	1	68
β-strand	133-134	2	74
β-strand	139	1	75
β-strand	146	1	75
β-strand	147-149	3	76
β-strand	153-155	3	76
β-strand	156-157	2	77
β-strand	230-231	2	74
β-strand	237	1	78
β-strand	244	1	78
β-strand	246-247	2	77

Chain H: 2 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	4-11	8	11
β-strand	12-16	5	79
β-strand	23-28	6	79
β-strand	37-39	3	11
β-strand	41-43	3	79
β-strand	54-60	7	11
α-helix	89-92	4
β-strand	95-108	14	11
β-strand	111-118	8	11
β-strand	121-127	7	11
α-helix	129-132	4
β-strand	139-145	7	11

6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae	P10964 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae	P22138 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae	P07703 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae	P50106 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae	P20435
DNA-directed RNA polymerase I subunit RPA43	G	protein	326	Saccharomyces cerevisiae	P46669
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae	P20436
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	Saccharomyces cerevisiae	P32529
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	Saccharomyces cerevisiae	P28000
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	Saccharomyces cerevisiae	P40422

5 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>9G26_1 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 2 (B), FASTA

>9G26_2 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 3 (C), FASTA

>9G26_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (D), FASTA

>9G26_4 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 5 (E), FASTA

>9G26_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>9G26_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>9G26_7 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Sequence of entity 8 (H), FASTA

>9G26_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>9G26_9 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 10 (J), FASTA

>9G26_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>9G26_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 12 (L), FASTA

>9G26_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	6
MG	Magnesium ion	Mg	1

Primary citation

Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions. Santos-Aledo, A., Plaza-Pegueroles, A., Sanz-Murillo, M. et al. Nat Commun (2025) 16:5254-5254. DOI 10.1038/s41467-025-60536-4 · PubMed

Other PDB entries of the same protein (UniProt P10964 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
9G1V 2.7 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site
4C2M 2.8 Å, Structure of RNA polymerase I at 2.8 A resolution
9G27 2.8 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, pre-translocation…
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
4C3I 3.0 Å, Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
6HLQ 3.18 Å, Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP
6HLR 3.18 Å, Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused)
9G2B 3.2 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, 12-subunit
6HLS 3.21 Å, Yeast apo RNA polymerase I*

Browse structure collections

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