9G2C: DNA-directed RNA polymerase I subunit RPA190

Yeast RNA polymerase I elongation complex stalled by an apurinic site, open state. Determined by electron microscopy at 3.5 Å resolution. Released 18 Jun 2025.

Method: Electron microscopy
Resolution: 3.5 Å
Organism: Saccharomyces cerevisiae
Chains: 16
Atoms: 29,270
Mol. weight: 602.91 kDa
Ligands: ZN
Released: 18 Jun 2025

Explore 9G2C in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9G2C contains 145 α-helices and 169 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 61 helices, 54 β-strands

Element	Residues	Length	Sheet
α-helix	135-137	3
α-helix	186-197	12
α-helix	317-330	14
α-helix	381-405	25
α-helix	406-408	3
α-helix	416-436	21
α-helix	467-470	4
β-strand	475	1	1
β-strand	479-482	4	2
β-strand	484	1	3
β-strand	494-497	4	2
α-helix	499-504	6
β-strand	506-510	5	4
α-helix	516-520	5
α-helix	522-525	4
β-strand	535	1	5
β-strand	536	1	4
β-strand	545	1	5
α-helix	551-554	4
β-strand	576-580	5	4
β-strand	586-590	5	2
α-helix	597-599	3
β-strand	600-607	8	2
β-strand	614	1	3
β-strand	615	1	2
α-helix	620-624	5
β-strand	633-636	4	2
α-helix	641-646	6
α-helix	647-651	5
β-strand	652	1	2
α-helix	654-656	3
β-strand	658	1	6
β-strand	665	1	6
α-helix	672-681	10
β-strand	687	1	7
α-helix	689-700	12
α-helix	702-704	3
β-strand	719	1	8
β-strand	725	1	8
β-strand	726	1	7
α-helix	728-739	12
α-helix	741	1
β-strand	749-752	4	9
α-helix	757-760	4
β-strand	768-771	4	9
β-strand	776	1	9
α-helix	793-823	31
β-strand	826	1	10
α-helix	830-833	4
β-strand	835	1	11
α-helix	837-847	11
α-helix	848-850	3
α-helix	853-861	9
α-helix	873-884	12
α-helix	886-911	26
β-strand	916	1	11
α-helix	924-930	7
α-helix	937-944	8
β-strand	948-949	2	12
β-strand	952	1	13
β-strand	955	1	13
β-strand	981-982	2	12
β-strand	985	1	14
β-strand	989	1	14
α-helix	992-1012	21
α-helix	1018-1026	9
β-strand	1031-1032	2	15
β-strand	1038-1039	2	15
β-strand	1045-1047	3	15
β-strand	1055	1	16
α-helix	1066-1070	5
α-helix	1073-1079	7
β-strand	1090	1	17
α-helix	1092-1107	16
α-helix	1123-1126	4
β-strand	1132	1	17
α-helix	1138-1148	11
α-helix	1163-1176	14
β-strand	1178	1	16
α-helix	1179-1180	2
α-helix	1187-1194	8
α-helix	1195-1197	3
α-helix	1218-1222	5
α-helix	1223-1227	5
β-strand	1237	1	18
α-helix	1253-1258	6
β-strand	1262	1	19
α-helix	1263-1266	4
β-strand	1267-1269	3	20
β-strand	1272-1275	4	21
β-strand	1290	1	22
β-strand	1295-1296	2	20
α-helix	1299-1305	7
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1336	15
α-helix	1442-1452	11
β-strand	1458-1459	2	23
β-strand	1472-1473	2	23
β-strand	1474	1	22
α-helix	1487-1495	9
β-strand	1497	1	19
β-strand	1504	1	24
β-strand	1522	1	18
β-strand	1523	1	24
α-helix	1549-1552	4
α-helix	1558-1573	16
α-helix	1579-1584	6
α-helix	1600-1603	4
α-helix	1609-1614	6
α-helix	1618-1624	7
α-helix	1639-1643	5
α-helix	1645-1647	3
α-helix	1650-1652	3
β-strand	1655-1657	3	25

Chain B: 48 helices, 60 β-strands

Element	Residues	Length	Sheet
α-helix	18-26	9
α-helix	36-51	16
α-helix	61-66	6
β-strand	97-102	6	26
β-strand	134	1	27
β-strand	139-143	5	26
β-strand	154-155	2	26
β-strand	162	1	27
α-helix	163-164	2
α-helix	177-182	6
β-strand	194	1	28
β-strand	201	1	28
β-strand	202-203	2	29
α-helix	204	1
β-strand	205-209	5	30
β-strand	215-216	2	31
α-helix	220-224	5
β-strand	229-239	11	31
β-strand	245-253	9	31
β-strand	258-264	7	31
β-strand	267-272	6	31
α-helix	273-280	8
α-helix	285-292	8
α-helix	301-316	16
α-helix	323-333	11
α-helix	346-356	11
α-helix	360-362	3
α-helix	367-386	20
β-strand	400-403	4	30
α-helix	405-430	26
α-helix	431-435	5
α-helix	443-451	9
α-helix	457-467	11
β-strand	469	1	32
β-strand	482	1	32
β-strand	485-486	2	29
α-helix	493-499	7
β-strand	502-504	3	30
α-helix	507-511	5
α-helix	516-518	3
α-helix	522-524	3
β-strand	528	1	33
β-strand	543-544	2	30
β-strand	545	1	33
α-helix	546	1
β-strand	550-551	2	34
α-helix	561-567	7
β-strand	572	1	35
β-strand	584-588	5	35
β-strand	591-596	6	35
α-helix	598-614	17
β-strand	625-629	5	35
β-strand	639-643	5	35
β-strand	649-650	2	34
β-strand	651-655	5	36
β-strand	660-664	5	36
α-helix	666-669	4
β-strand	674-675	2	36
α-helix	678-680	3
β-strand	688-689	2	36
α-helix	693-695	3
α-helix	699-702	4
α-helix	707-709	3
α-helix	712-722	11
β-strand	725	1	37
α-helix	733-735	3
β-strand	743	1	38
α-helix	753-754	2
α-helix	762-764	3
β-strand	769-775	7	39
β-strand	777	1	10
β-strand	787-790	4	39
α-helix	791-795	5
β-strand	802-810	9	38
β-strand	823-825	3	40
α-helix	836-838	3
β-strand	851-852	2	38
β-strand	859-863	5	40
β-strand	868-872	5	40
β-strand	880-888	9	38
β-strand	900-908	9	38
β-strand	916-919	4	39
β-strand	925-931	7	39
β-strand	938-939	2	41
β-strand	947-949	3	39
α-helix	953-957	5
α-helix	960-975	16
α-helix	977-980	4
α-helix	988-990	3
α-helix	992-1003	12
β-strand	1010-1011	2	39
β-strand	1013-1014	2	41
α-helix	1020	1
β-strand	1021	1	41
α-helix	1022	1
β-strand	1026-1035	10	39
β-strand	1036	1	37
β-strand	1045-1047	3	2
α-helix	1059-1060	2
β-strand	1061	1	42
β-strand	1068	1	42
β-strand	1070	1	1
α-helix	1073-1081	9
α-helix	1085-1091	7
β-strand	1104	1	43
α-helix	1123-1124	2
β-strand	1173	1	43
α-helix	1181-1192	12

Chain C: 12 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	33-39	7
β-strand	41-43	3	44
β-strand	52	1	45
β-strand	55-57	3	44
α-helix	61-69	9
α-helix	70-74	5
β-strand	77-88	12	46
α-helix	94-102	9
α-helix	122-125	4
β-strand	132-135	4	46
β-strand	138-140	3	46
β-strand	141-142	2	47
α-helix	153-156	4
β-strand	157-158	2	47
β-strand	161-163	3	48
α-helix	164-166	3
β-strand	168	1	46
α-helix	175-178	4
β-strand	192-195	4	48
β-strand	200-211	12	46
α-helix	217-219	3
β-strand	227-235	9	44
β-strand	240	1	49
α-helix	242-250	9
β-strand	256-259	4	49
β-strand	264-267	4	49
α-helix	278-281	4
β-strand	289-300	12	44
β-strand	302	1	45
α-helix	310-330	21

Chain E: 9 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	6-26	21
α-helix	32-36	5
α-helix	39-45	7
β-strand	61-62	2	50
α-helix	68-70	3
β-strand	80-81	2	50
α-helix	118-121	4
α-helix	152-155	4
α-helix	162-168	7
α-helix	172-174	3
α-helix	183-187	5

Chain F: 4 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	56-60	5
α-helix	66-71	6
β-strand	73	1	51
α-helix	87-102	16
α-helix	117-127	11
β-strand	133-135	3	25
β-strand	143	1	51
β-strand	145-147	3	25

Chain G: 0 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	55	1	52
β-strand	102	1	52
β-strand	106	1	25

Chain H: 2 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	4-12	9	8
β-strand	15-16	2	53
β-strand	23-29	7	53
β-strand	30	1	8
β-strand	37-43	7	53
β-strand	53-60	8	8
α-helix	89-92	4
β-strand	95-97	3	8
β-strand	100-108	9	53
β-strand	111-118	8	53
β-strand	121-127	7	53
α-helix	129-132	4
β-strand	139	1	53
β-strand	141-145	5	8

Chain I: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	46-49	4	21

5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae	P10964 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae	P22138 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae	P07703 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae	P20434 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae	P20435
DNA-directed RNA polymerase I subunit RPA43	G	protein	326	Saccharomyces cerevisiae	P46669
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae	P20436
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	Saccharomyces cerevisiae	P32529
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	Saccharomyces cerevisiae	P28000
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	Saccharomyces cerevisiae	P40422
DNA-directed RNA polymerase I subunit RPA49	M	protein	415	Saccharomyces cerevisiae	Q01080

4 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>9G2C_1 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 2 (B), FASTA

>9G2C_2 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 3 (C), FASTA

>9G2C_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (E), FASTA

>9G2C_4 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 5 (F), FASTA

>9G2C_5 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 6 (G), FASTA

>9G2C_6 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Sequence of entity 7 (H), FASTA

>9G2C_7 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 8 (I), FASTA

>9G2C_8 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 9 (J), FASTA

>9G2C_9 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 10 (K), FASTA

>9G2C_10 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 11 (L), FASTA

>9G2C_11 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Sequence of entity 12 (M), FASTA

>9G2C_12 DNA-directed RNA polymerase I subunit RPA49 (chains M)
MSVKRSVSEIEIESVQDQPSVAVGSFFKGFRAPSDTTFDLYKKKKSEKDEFVLHGENERL
EYEGYTDSSSQASNQYVVGLFNPEKKSIQLYKAPVLVSKVVSKSSKNLRGPKIKSKSDTR
PSALRNALGEAFGTKKAKKAIADLERNRIDSDKLTDSAIDIVDSVRTASKDLPTRAQLDE
ITSNDRPTPLANIDATDVEQIYPIESIIPKKELQFIRVSSILKEADKEKKLELFPYQNNS
KYVAKKLDSLTQPSQMTKLQLLYYLSLLLGVYENRRVNNKTKLLERLNSPPEILVDGILS
RFTVIKPGQFGRSKDRSYFIDPQNEDKILCYILAIIMHLDNFIVEITPLAHELNLKPSKV
VSLFRVLGAIVKGATVAQAEAFGIPKSTAASYKIATMKVPFKLPEMTRRGRGPRR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	4

Primary citation

Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions. Santos-Aledo, A., Plaza-Pegueroles, A., Sanz-Murillo, M. et al. Nat Commun (2025) 16:5254-5254. DOI 10.1038/s41467-025-60536-4 · PubMed

Other PDB entries of the same protein (UniProt P10964 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
9G1V 2.7 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site
4C2M 2.8 Å, Structure of RNA polymerase I at 2.8 A resolution
9G27 2.8 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, pre-translocation…
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
4C3I 3.0 Å, Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
6HLQ 3.18 Å, Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP
6HLR 3.18 Å, Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused)
9G2B 3.2 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, 12-subunit
6HLS 3.21 Å, Yeast apo RNA polymerase I*

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