9HVA: Fab34

Crystal structure of Fab34 complexed with a 18-mer peptide of FMDV VP1. Determined by X-ray diffraction at 3.89 Å resolution. Released 14 Jan 2026.

Method: X-ray diffraction
Resolution: 3.89 Å
Organisms: Bos taurus, Foot-and-mouth disease virus
Chains: 18
Atoms: 19,818
Mol. weight: 299.29 kDa
Released: 14 Jan 2026

Explore 9HVA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9HVA contains 84 α-helices and 287 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 1 β-strand

Element	Residues	Length	Sheet
β-strand	205-206	2	4
α-helix	208-210	3

Chain B: 6 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	14
β-strand	11-12	2	15
β-strand	18-25	8	14
α-helix	29-31	3
β-strand	34-39	6	16
β-strand	45-51	7	16
β-strand	57-59	3	16
α-helix	64-66	3
β-strand	67-72	6	14
β-strand	77-82	6	14
α-helix	87-89	3
β-strand	91-97	7	16
β-strand	108-110	3	17
α-helix	111-113	3
β-strand	117-118	2	16
β-strand	122-124	3	16
β-strand	125-126	2	15
β-strand	132	1	18
α-helix	133-134	2
β-strand	135-140	6	19
β-strand	150-160	11	19
β-strand	161	1	18
β-strand	166-169	4	20
β-strand	174	1	20
β-strand	178-180	3	19
β-strand	184-185	2	19
β-strand	191-200	10	19
β-strand	209-215	7	20
α-helix	216-218	3
β-strand	220-226	7	20

Chain C: 7 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	6	1	21
β-strand	10-14	5	22
β-strand	19-24	6	21
β-strand	34-38	5	22
β-strand	45-48	4	22
β-strand	49	1	23
β-strand	53	1	23
β-strand	62-67	6	21
β-strand	70-75	6	21
α-helix	80-82	3
β-strand	84-91	8	22
β-strand	97-99	3	22
β-strand	103-108	6	22
β-strand	113	1	24
α-helix	114-115	2
β-strand	116-120	5	25
α-helix	121-123	3
α-helix	124-127	4
β-strand	131-141	11	25
β-strand	142	1	24
β-strand	147-152	6	26
β-strand	155-157	3	26
β-strand	161-163	3	25
α-helix	164-166	3
β-strand	167-168	2	25
β-strand	174-183	10	25
α-helix	184-189	6
β-strand	193-199	7	26
β-strand	202-208	7	26
α-helix	210-212	3

Chains D, K and O: 1 helix, 1 β-strand

Element	Residues	Length	Sheet
β-strand	204-206	3	17
α-helix	208-210	3

Chains E, I and P: 6 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	27
β-strand	11-12	2	28
β-strand	18-25	8	27
α-helix	29-31	3
β-strand	34-39	6	29
β-strand	45-51	7	29
β-strand	57-59	3	29
α-helix	64-66	3
β-strand	67-72	6	27
β-strand	77-82	6	27
α-helix	87-89	3
β-strand	91-97	7	29
β-strand	108-110	3	30
α-helix	111-113	3
β-strand	117-118	2	29
β-strand	122-124	3	29
β-strand	125-126	2	28
β-strand	132	1	31
α-helix	133-134	2
β-strand	135-140	6	32
β-strand	150-160	11	32
β-strand	161	1	31
β-strand	166-169	4	33
β-strand	178-180	3	32
β-strand	184-185	2	32
β-strand	191-200	10	32
β-strand	209-215	7	33
α-helix	216-218	3
β-strand	220-226	7	33

Chains F and Q: 7 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	6	1	34
β-strand	10-14	5	35
β-strand	19-24	6	34
β-strand	31	1	36
β-strand	34-38	5	35
β-strand	45-48	4	35
β-strand	49	1	37
β-strand	53	1	37
β-strand	62-67	6	34
β-strand	70-75	6	34
α-helix	80-82	3
β-strand	84-91	8	35
β-strand	97-99	3	35
β-strand	103-108	6	35
β-strand	113	1	38
α-helix	114-115	2
β-strand	116-120	5	39
α-helix	121-123	3
α-helix	124-127	4
β-strand	131-141	11	39
β-strand	142	1	38
β-strand	147-152	6	40
β-strand	155-157	3	40
β-strand	161-163	3	39
α-helix	164-166	3
β-strand	167-168	2	39
β-strand	174-183	10	39
α-helix	184-189	6
β-strand	193-199	7	40
β-strand	202-208	7	40
α-helix	210-212	3

Chains G and R: 2 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	204-206	3	30
α-helix	208	1
β-strand	209	1	36
α-helix	210	1

Chain H: 5 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	1
β-strand	11-12	2	2
β-strand	18-25	8	1
β-strand	34-39	6	3
β-strand	45-52	8	3
β-strand	56-59	4	3
α-helix	64-66	3
β-strand	67-72	6	1
β-strand	77-82	6	1
α-helix	87-89	3
β-strand	91-97	7	3
β-strand	109-110	2	4
α-helix	111-113	3
β-strand	117-118	2	3
β-strand	122-124	3	3
β-strand	125-126	2	2
β-strand	132	1	5
α-helix	133-134	2
β-strand	135-140	6	6
β-strand	150-160	11	6
β-strand	161	1	5
β-strand	166-169	4	7
β-strand	178-180	3	6
β-strand	184-185	2	6
β-strand	191-200	10	6
β-strand	209-215	7	7
α-helix	216-218	3
β-strand	220-226	7	7

4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
heavy chain	B, E, H, I, M, P	protein	238	Bos taurus
light chain	C, F, J, L, N, Q	protein	213	Bos taurus
Capsid protein VP1	A, D, G, K, O, R	protein	18	Foot-and-mouth disease virus	P03305

Sequence of entity 1 (B, E, H, I, M, P), FASTA

>9HVA_1 heavy chain (chains B, E, H, I, M, P)
QVQLRESGPSLVKPSQTLSLTCTVSGFSLTDVHVGWVRQTPGKALEWVGVICNRGAIGYN
PALESRLSITEDNSKSQVSLSLSSVTTADTATYYCASSCRTEGDVGGDCDSDHFFCAWGQ
GLLVTVSSASTTAPKVYPLSSCCGDKSSSTVTLGCLVSSYMPEPVTVTWNSGALKSGVHT
FPAVLQSSGLYSLSSMVTVPGSTSGTQTFTCNVAHPASSTKVDKAVDPRCGKHHHHHH

Sequence of entity 2 (C, F, J, L, N, Q), FASTA

>9HVA_2 light chain (chains C, F, J, L, N, Q)
SYELTQPTSVSVALGQTAKITCSGDLLDRQYAQWYQQKPGQGPVRVIYKDSERPSGISDR
FSGSSSGKTATLTVSGAQTEDEADYYCHSADSSHYPVFGSGSTLTVLGQPKSPPSVTLFP
PSTEELNGNKATLVCLISDFYPGSVTVVWKADGSTITRNVETTRASKQSNSKYAASSYLS
LTSSDWKSKGSYSCEVTHEGSTVTKTVKPSECS

Sequence of entity 3 (A, D, G, K, O, R), FASTA

>9HVA_3 Capsid protein VP1 (chains A, D, G, K, O, R)
IHPDQARHKQKIVAPVKQ

Primary citation

Cattle antibodies identify a cross-serotype broadly neutralising foot-and-mouth disease virus epitope. Bonnet-Di Placido, M., Duyvesteyn, H.M.E., Steyn, A.W. et al. NPJ Vaccines (2026) 11. DOI 10.1038/s41541-026-01427-7 · PubMed

Other PDB entries of the same protein (UniProt P03305), best resolution first:

6FFA 1.5 Å, FMDV Leader protease bound to substrate ISG15
4QBB 1.6 Å, Structure of the foot-and-mouth disease virus leader proteinase in complex with…
9HV9 1.8 Å, Crystal structure of Fab34 complexed with a 7-mer peptide of FMDV VP1
1QMY 1.9 Å, Fmdv leader protease (lbshort-C51A-C133S)
1QQP 1.9 Å, Foot-and-mouth disease virus/ oligosaccharide receptor complex.
1QOL 3.0 Å, Structure of the fmdv leader protease
2JQF Full Length Leader Protease of Foot and Mouth Disease Virus C51A Mutant
2JQG Leader Protease

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