Structure of human B0AT1-ACE2 complex with compound1. Determined by electron microscopy at 2.7 Å resolution. Released 10 Dec 2025.
Explore 9KXT in 3D Show helices and sheets RCSB PDB PDBe
9KXT contains 41 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 18-21 | 4 | |
| α-helix | 39-53 | 15 | |
| α-helix | 57-64 | 8 | |
| α-helix | 68-77 | 10 | |
| α-helix | 78-82 | 5 | |
| α-helix | 83-96 | 14 | |
| α-helix | 100-107 | 8 | |
| α-helix | 113-141 | 29 | |
| α-helix | 153-154 | 2 | |
| β-strand | 155 | 1 | 1 |
| α-helix | 156 | 1 | |
| β-strand | 162 | 1 | 1 |
| α-helix | 164-168 | 5 | |
| α-helix | 171-174 | 4 | |
| α-helix | 175-180 | 6 | |
| α-helix | 195-211 | 17 | |
| α-helix | 216-243 | 28 | |
| α-helix | 251-254 | 4 | |
| α-helix | 259-262 | 4 | |
| α-helix | 265-278 | 14 | |
| α-helix | 285-290 | 6 | |
| α-helix | 299-348 | 50 | |
| α-helix | 361-367 | 7 | |
| α-helix | 385-390 | 6 | |
| α-helix | 397 | 1 | |
| α-helix | 398-403 | 6 | |
| α-helix | 404-408 | 5 | |
| α-helix | 413-446 | 34 | |
| α-helix | 455-469 | 15 | |
| α-helix | 470-474 | 5 | |
| α-helix | 478-489 | 12 | |
| α-helix | 492-503 | 12 | |
| α-helix | 504-508 | 5 | |
| α-helix | 511-522 | 12 | |
| α-helix | 525-527 | 3 | |
| α-helix | 528-532 | 5 | |
| α-helix | 533-537 | 5 | |
| α-helix | 538-555 | 18 | |
| β-strand | 560-562 | 3 | 2 |
| β-strand | 574-576 | 3 | 2 |
| α-helix | 577-579 | 3 | |
| α-helix | 582-586 | 5 | |
| α-helix | 587-591 | 5 | |
| α-helix | 592-605 | 14 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 741-766 | 26 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Sodium-dependent neutral amino acid transporter B(0)AT1 | A | protein | 654 | Homo sapiens | Q695T7 (AlphaFold model) |
| Angiotensin-converting enzyme 2 | B | protein | 806 | Homo sapiens | Q9BYF1 (AlphaFold model) |
>9KXT_1 Sodium-dependent neutral amino acid transporter B(0)AT1 (chains A) MADYKDDDDKSGPDEVDASGRVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQ YMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGS LGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQT GYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTG KAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFS LAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTN ILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAF IVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTG LICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEF MIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPN WVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY
>9KXT_2 Angiotensin-converting enzyme 2 (chains B) MRSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENV QNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTI LNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPL YEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEH LHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVD QAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRIL MCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWE MKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPL HKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQN KNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVK NQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLND NSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGEN PYASIDISKGENNPGFQNTDDVQTSF
| ID | Name | Formula | Copies |
|---|---|---|---|
| A1L6U | 3-(3-bromophenyl)-~{N}-ethyl-propanamide | C11 H14 Br N O | 1 |
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 1 |
Structure-guided development of a potent human B 0 AT1 inhibitor effective in a mouse model of phenylketonuria. Imazu, T., Akashi, T., Hiraizumi, M. et al. Commun Biol (2026). DOI 10.1038/s42003-026-10535-y · PubMed
Other PDB entries of the same protein (UniProt Q695T7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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