Structure of human B0AT1-ACE2 complex with compound 2. Determined by electron microscopy at 2.87 Å resolution. Released 10 Dec 2025.
Explore 9KXU in 3D Show helices and sheets RCSB PDB PDBe
9KXU contains 40 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 18-31 | 14 | |
| α-helix | 38-50 | 13 | |
| α-helix | 57-63 | 7 | |
| α-helix | 71-77 | 7 | |
| α-helix | 78-82 | 5 | |
| α-helix | 83-96 | 14 | |
| α-helix | 100-107 | 8 | |
| α-helix | 109-113 | 5 | |
| α-helix | 114-141 | 28 | |
| β-strand | 155 | 1 | 1 |
| β-strand | 162 | 1 | 1 |
| α-helix | 164-168 | 5 | |
| α-helix | 171-174 | 4 | |
| α-helix | 175-180 | 6 | |
| α-helix | 195-211 | 17 | |
| α-helix | 216-226 | 11 | |
| α-helix | 229-233 | 5 | |
| α-helix | 236-242 | 7 | |
| α-helix | 247-255 | 9 | |
| α-helix | 259-262 | 4 | |
| α-helix | 265-278 | 14 | |
| α-helix | 285-290 | 6 | |
| α-helix | 299-347 | 49 | |
| α-helix | 358-367 | 10 | |
| α-helix | 386-389 | 4 | |
| α-helix | 397 | 1 | |
| α-helix | 398-402 | 5 | |
| α-helix | 403-407 | 5 | |
| α-helix | 413-445 | 33 | |
| α-helix | 455-469 | 15 | |
| α-helix | 472-474 | 3 | |
| α-helix | 478-484 | 7 | |
| α-helix | 488-490 | 3 | |
| α-helix | 492-507 | 16 | |
| α-helix | 511-522 | 12 | |
| α-helix | 528-532 | 5 | |
| α-helix | 533-537 | 5 | |
| α-helix | 538-552 | 15 | |
| β-strand | 559-562 | 4 | 2 |
| β-strand | 574-577 | 4 | 2 |
| α-helix | 578-579 | 2 | |
| α-helix | 582-594 | 13 | |
| α-helix | 596-605 | 10 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 741-766 | 26 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Sodium-dependent neutral amino acid transporter B(0)AT1 | A | protein | 654 | Homo sapiens | Q695T7 (AlphaFold model) |
| Angiotensin-converting enzyme 2 | B | protein | 806 | Homo sapiens | Q9BYF1 (AlphaFold model) |
>9KXU_1 Sodium-dependent neutral amino acid transporter B(0)AT1 (chains A) MADYKDDDDKSGPDEVDASGRVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQ YMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGS LGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQT GYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTG KAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFS LAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTN ILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAF IVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTG LICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEF MIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPN WVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY
>9KXU_2 Angiotensin-converting enzyme 2 (chains B) MRSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENV QNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTI LNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPL YEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEH LHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVD QAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRIL MCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWE MKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPL HKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQN KNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVK NQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLND NSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGEN PYASIDISKGENNPGFQNTDDVQTSF
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 1 |
| A1L6V | (~{E})-~{N}-[2-(dimethylamino)-2-oxidanylidene-ethyl]-3-[4-(trifluoromethyl)phe… | C14 H15 F3 N2 O2 | 1 |
Structure-guided development of a potent human B 0 AT1 inhibitor effective in a mouse model of phenylketonuria. Imazu, T., Akashi, T., Hiraizumi, M. et al. Commun Biol (2026). DOI 10.1038/s42003-026-10535-y · PubMed
Other PDB entries of the same protein (UniProt Q695T7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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