Structure of human B0AT1-ACE2. Determined by electron microscopy at 2.66 Å resolution. Released 10 Dec 2025.
Explore 9KXW in 3D Show helices and sheets RCSB PDB PDBe
9KXW contains 42 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 12 | 1 | 1 |
| β-strand | 15 | 1 | 1 |
| α-helix | 21-24 | 4 | |
| α-helix | 38-49 | 12 | |
| α-helix | 53-56 | 4 | |
| α-helix | 58-64 | 7 | |
| α-helix | 71-77 | 7 | |
| α-helix | 78-82 | 5 | |
| α-helix | 83-96 | 14 | |
| α-helix | 100-107 | 8 | |
| α-helix | 109-111 | 3 | |
| α-helix | 112-141 | 30 | |
| α-helix | 153-154 | 2 | |
| β-strand | 155 | 1 | 2 |
| α-helix | 156 | 1 | |
| β-strand | 162 | 1 | 2 |
| α-helix | 164-168 | 5 | |
| α-helix | 171-177 | 7 | |
| α-helix | 195-211 | 17 | |
| α-helix | 216-226 | 11 | |
| α-helix | 229-243 | 15 | |
| α-helix | 249-254 | 6 | |
| α-helix | 259-262 | 4 | |
| α-helix | 265-278 | 14 | |
| α-helix | 285-290 | 6 | |
| α-helix | 300-347 | 48 | |
| β-strand | 356 | 1 | 3 |
| β-strand | 359 | 1 | 3 |
| α-helix | 361-364 | 4 | |
| α-helix | 385-389 | 5 | |
| α-helix | 397 | 1 | |
| α-helix | 398-403 | 6 | |
| α-helix | 404-408 | 5 | |
| α-helix | 413-446 | 34 | |
| α-helix | 455-469 | 15 | |
| α-helix | 472-474 | 3 | |
| α-helix | 478-486 | 9 | |
| α-helix | 492-503 | 12 | |
| α-helix | 504-508 | 5 | |
| α-helix | 511-522 | 12 | |
| α-helix | 528-532 | 5 | |
| α-helix | 533-537 | 5 | |
| α-helix | 538-552 | 15 | |
| α-helix | 553-555 | 3 | |
| β-strand | 559-562 | 4 | 4 |
| β-strand | 574-577 | 4 | 4 |
| α-helix | 578-579 | 2 | |
| α-helix | 582-590 | 9 | |
| α-helix | 592-608 | 17 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 741-767 | 27 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Sodium-dependent neutral amino acid transporter B(0)AT1 | A | protein | 654 | Homo sapiens | Q695T7 (AlphaFold model) |
| Angiotensin-converting enzyme 2 | B | protein | 806 | Homo sapiens | Q9BYF1 (AlphaFold model) |
>9KXW_1 Sodium-dependent neutral amino acid transporter B(0)AT1 (chains A) MADYKDDDDKSGPDEVDASGRVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQ YMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGS LGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQT GYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTG KAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFS LAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTN ILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAF IVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTG LICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEF MIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPN WVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY
>9KXW_2 Angiotensin-converting enzyme 2 (chains B) MRSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENV QNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTI LNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPL YEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEH LHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVD QAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRIL MCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWE MKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPL HKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQN KNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVK NQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLND NSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGEN PYASIDISKGENNPGFQNTDDVQTSF
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 1 |
Water and common crystallization additives (NA) are not listed.
Structure-guided development of a potent human B 0 AT1 inhibitor effective in a mouse model of phenylketonuria. Imazu, T., Akashi, T., Hiraizumi, M. et al. Commun Biol (2026). DOI 10.1038/s42003-026-10535-y · PubMed
Other PDB entries of the same protein (UniProt Q695T7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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