9KY1: Human B0AT1-ACE2 complex with compound1

Structure of human B0AT1-ACE2 complex with compound1. Determined by electron microscopy at 2.8 Å resolution. Released 10 Dec 2025.

Method
Electron microscopy
Resolution
2.8 Å
Organism
Homo sapiens
Chains
4
Atoms
22,062
Mol. weight
337.54 kDa
Ligands
NAG
Released
10 Dec 2025

Explore 9KY1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9KY1 contains 167 α-helices and 38 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 42 helices, 2 β-strands

ElementResiduesLengthSheet
α-helix11-144
α-helix16-172
α-helix21-244
α-helix39-4911
α-helix53-564
α-helix58-647
α-helix68-7710
α-helix78-825
α-helix83-9614
α-helix100-1078
α-helix109-1113
α-helix112-14130
α-helix164-1674
α-helix171-1744
α-helix175-1806
α-helix195-21218
α-helix216-24126
α-helix247-2548
α-helix259-2635
α-helix265-27814
α-helix285-2906
α-helix299-34850
α-helix350-3512
α-helix360-37011
α-helix372-3776
α-helix385-3895
α-helix396-3972
α-helix398-4036
α-helix404-4085
α-helix413-44533
α-helix455-46915
α-helix472-4743
α-helix478-48710
α-helix492-50312
α-helix504-5085
α-helix511-52111
α-helix525-5273
α-helix528-5325
α-helix533-5375
α-helix538-55215
β-strand559-56131
β-strand575-57731
α-helix582-5909
α-helix592-60817
Chain B: 41 helices, 17 β-strands
ElementResiduesLengthSheet
α-helix22-5231
α-helix59-7618
α-helix77-793
α-helix91-999
α-helix104-1074
α-helix110-12819
β-strand131-13332
β-strand141-14332
α-helix144-1485
α-helix149-1546
α-helix158-16811
α-helix169-1735
α-helix174-19219
α-helix199-2046
β-strand20913
β-strand21713
α-helix219-23113
α-helix234-25118
β-strand26014
α-helix2611
β-strand262-26325
α-helix264-2663
α-helix276-2816
α-helix294-3007
α-helix306-31712
α-helix320-3245
α-helix325-3295
β-strand33216
β-strand347-35266
β-strand355-35956
α-helix366-38419
α-helix400-41314
α-helix415-4206
α-helix432-44615
α-helix450-46516
α-helix473-4808
α-helix481-4855
β-strand487-48825
α-helix499-5024
α-helix504-5074
α-helix514-53219
α-helix539-5413
α-helix548-56013
α-helix566-5749
α-helix582-5876
α-helix589-59810
β-strand60714
β-strand618-62257
α-helix624-6285
α-helix632-6343
α-helix637-65721
β-strand670-67677
β-strand680-68567
β-strand686-68728
β-strand690-69458
α-helix697-71317
β-strand722-72547
α-helix741-76525
Chain C: 44 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix11-144
α-helix18-2811
α-helix39-4911
α-helix53-564
α-helix58-647
α-helix67-704
α-helix71-777
α-helix78-825
α-helix83-9614
α-helix100-1078
α-helix109-1113
α-helix112-14130
α-helix149-1513
α-helix164-1685
α-helix171-1744
α-helix175-1795
α-helix195-21218
α-helix216-24126
α-helix247-2548
α-helix259-2635
α-helix265-27814
α-helix285-2917
α-helix299-34850
α-helix350-3512
α-helix360-37011
α-helix372-3776
α-helix385-3906
α-helix396-3972
α-helix398-4036
α-helix404-4085
α-helix413-44533
α-helix455-47016
α-helix471-4744
α-helix478-48710
α-helix492-50312
α-helix504-5107
α-helix511-52111
α-helix525-5273
α-helix528-5325
α-helix533-5375
α-helix538-55215
β-strand559-56139
β-strand575-57739
α-helix578-5792
α-helix582-5909
α-helix592-60817
Chain D: 40 helices, 17 β-strands
ElementResiduesLengthSheet
α-helix22-5130
α-helix56-8227
α-helix91-10111
α-helix104-1074
α-helix110-12920
β-strand131-133310
β-strand141-143310
α-helix144-1485
α-helix149-1546
α-helix158-16811
α-helix169-1735
α-helix174-19320
α-helix199-2046
β-strand209111
β-strand217111
α-helix219-23113
α-helix234-25118
β-strand260112
α-helix2611
β-strand262-263213
α-helix264-2663
α-helix276-2783
α-helix279-2824
α-helix294-2996
α-helix304-31613
α-helix320-3245
α-helix325-3306
β-strand332114
β-strand347-352614
β-strand355-359514
α-helix366-38318
α-helix400-41213
α-helix415-4206
α-helix432-44615
α-helix450-46415
α-helix473-4808
α-helix481-4855
β-strand487-488213
α-helix499-5024
α-helix504-5074
α-helix514-53219
α-helix548-56013
α-helix566-5749
α-helix582-5876
α-helix589-59810
β-strand607112
β-strand618-622515
α-helix624-6274
α-helix632-6343
α-helix637-65721
β-strand670-673415
β-strand680-685615
β-strand686-687216
β-strand690-694516
α-helix697-71418
β-strand722-723215
α-helix741-76626

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Sodium-dependent neutral amino acid transporter B(0)AT1A, Cprotein654Homo sapiensQ695T7 (AlphaFold model)
Angiotensin-converting enzyme 2B, Dprotein806Homo sapiensQ9BYF1 (AlphaFold model)
Sequence of entity 1 (A, C), FASTA
>9KY1_1 Sodium-dependent neutral amino acid transporter B(0)AT1 (chains A, C)
MADYKDDDDKSGPDEVDASGRVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQ
YMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGS
LGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQT
GYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTG
KAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFS
LAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTN
ILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAF
IVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTG
LICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEF
MIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPN
WVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY
Sequence of entity 2 (B, D), FASTA
>9KY1_2 Angiotensin-converting enzyme 2 (chains B, D)
MRSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENV
QNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTI
LNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPL
YEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEH
LHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVD
QAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRIL
MCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK
SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWE
MKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPL
HKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQN
KNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVK
NQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLND
NSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGEN
PYASIDISKGENNPGFQNTDDVQTSF

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O62

Primary citation

Structure-guided development of a potent human B 0 AT1 inhibitor effective in a mouse model of phenylketonuria. Imazu, T., Akashi, T., Hiraizumi, M. et al. Commun Biol (2026). DOI 10.1038/s42003-026-10535-y · PubMed

Other PDB entries of the same protein (UniProt Q695T7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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