9KXZ: Human B0AT1-ACE2 complex with compound1

Structure of human B0AT1-ACE2 complex with compound1. Determined by electron microscopy at 2.8 Å resolution. Released 10 Dec 2025.

Method
Electron microscopy
Resolution
2.8 Å
Organism
Homo sapiens
Chains
4
Atoms
22,010
Mol. weight
337.29 kDa
Ligands
NAG, A1L6V
Released
10 Dec 2025

Explore 9KXZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9KXZ contains 173 α-helices and 42 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 42 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix18-269
α-helix38-4912
α-helix57-637
α-helix71-777
α-helix78-825
α-helix83-9614
α-helix100-1078
α-helix109-1135
α-helix114-14128
β-strand15511
β-strand16211
α-helix164-1685
α-helix171-1744
α-helix175-1806
α-helix191-1933
α-helix195-21117
α-helix216-2194
α-helix223-2264
α-helix229-24214
α-helix247-2537
α-helix259-2613
α-helix265-27814
α-helix285-2906
α-helix299-34749
α-helix350-3512
α-helix361-37010
α-helix372-3754
α-helix386-3894
α-helix392-3943
α-helix3971
α-helix398-4025
α-helix403-4097
α-helix413-44533
α-helix455-46915
α-helix472-4743
α-helix478-4836
α-helix488-50720
α-helix511-52212
α-helix525-5273
α-helix528-5325
α-helix533-5375
α-helix538-55619
β-strand559-56132
β-strand575-57732
α-helix578-5792
α-helix580-60829
Chain B: 42 helices, 16 β-strands
ElementResiduesLengthSheet
α-helix22-5231
α-helix56-8126
α-helix91-10111
α-helix104-1074
α-helix110-12920
β-strand131-13333
β-strand141-14333
α-helix144-1485
α-helix149-1546
α-helix158-16811
α-helix169-1735
α-helix174-19320
α-helix199-2046
β-strand20914
β-strand21714
α-helix219-25133
β-strand26015
β-strand262-26326
α-helix264-2663
α-helix276-2783
α-helix279-2824
α-helix294-2996
α-helix304-31714
α-helix321-3244
α-helix325-3295
β-strand347-35047
β-strand356-35947
α-helix366-38520
α-helix390-3923
α-helix400-41314
α-helix415-4217
α-helix432-46433
α-helix470-4723
α-helix473-4808
α-helix481-4855
β-strand487-48826
α-helix499-5024
α-helix504-5074
α-helix513-53220
α-helix539-5413
α-helix548-56013
α-helix566-5738
α-helix582-59817
β-strand60715
α-helix614-6163
α-helix6171
β-strand618-62148
α-helix624-6285
α-helix637-65822
α-helix667-6693
β-strand670-67348
β-strand681-68558
β-strand686-68729
β-strand690-69459
α-helix695-6962
α-helix697-71418
β-strand723-72428
α-helix741-76727
Chain C: 44 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix21-233
α-helix38-4912
α-helix57-637
α-helix71-777
α-helix78-825
α-helix83-9614
α-helix100-1078
α-helix109-1113
α-helix112-14130
α-helix1541
β-strand155110
α-helix1561
β-strand162110
α-helix164-1685
α-helix171-1744
α-helix175-1806
α-helix195-21117
α-helix216-2194
α-helix223-2264
α-helix229-24214
α-helix247-2559
α-helix259-2613
α-helix265-27814
α-helix285-2906
α-helix299-34850
α-helix350-3512
α-helix357-3593
α-helix361-37010
α-helix372-3765
α-helix386-3905
α-helix391-3944
α-helix3971
α-helix398-4036
α-helix404-4096
α-helix413-44533
α-helix455-46915
α-helix472-4743
α-helix478-4847
α-helix488-50720
α-helix511-52212
α-helix525-5273
α-helix528-5325
α-helix533-5375
α-helix538-55114
β-strand559-562411
β-strand574-577411
α-helix578-5792
α-helix582-60524
Chain D: 45 helices, 18 β-strands
ElementResiduesLengthSheet
α-helix22-5332
α-helix56-8227
α-helix91-10111
α-helix104-1074
α-helix110-12920
β-strand131-133312
β-strand141-143312
α-helix144-1485
α-helix149-1546
α-helix158-19336
α-helix199-2046
α-helix205-2073
β-strand209113
β-strand217113
α-helix219-25133
β-strand260114
β-strand262-263215
α-helix264-2663
α-helix276-2783
α-helix279-2824
α-helix294-2996
α-helix304-31714
α-helix320-3245
α-helix325-3295
β-strand333116
β-strand347-352617
β-strand355-359517
β-strand360116
α-helix366-38419
α-helix385-3873
α-helix390-3923
α-helix401-41313
α-helix415-4206
α-helix432-44615
α-helix449-46416
α-helix470-4723
α-helix473-4808
α-helix481-4855
β-strand487-488215
α-helix499-5024
α-helix504-5074
α-helix513-53321
α-helix539-5413
α-helix548-56013
α-helix566-5716
α-helix582-5876
α-helix589-59810
β-strand607114
α-helix614-6163
α-helix6171
β-strand618-622518
α-helix624-6274
α-helix632-6354
α-helix637-65721
α-helix667-6693
β-strand670-673418
β-strand680-685618
β-strand686-687219
β-strand690-694519
α-helix695-6962
α-helix697-71418
β-strand722-724318
α-helix741-76727

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Sodium-dependent neutral amino acid transporter B(0)AT1A, Cprotein654Homo sapiensQ695T7 (AlphaFold model)
Angiotensin-converting enzyme 2B, Dprotein806Homo sapiensQ9BYF1 (AlphaFold model)
Sequence of entity 1 (A, C), FASTA
>9KXZ_1 Sodium-dependent neutral amino acid transporter B(0)AT1 (chains A, C)
MADYKDDDDKSGPDEVDASGRVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQ
YMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGS
LGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQT
GYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTG
KAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFS
LAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTN
ILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAF
IVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTG
LICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEF
MIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPN
WVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY
Sequence of entity 2 (B, D), FASTA
>9KXZ_2 Angiotensin-converting enzyme 2 (chains B, D)
MRSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENV
QNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTI
LNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPL
YEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEH
LHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVD
QAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRIL
MCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK
SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWE
MKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPL
HKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQN
KNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVK
NQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLND
NSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGEN
PYASIDISKGENNPGFQNTDDVQTSF

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O62
A1L6V(~{E})-~{N}-[2-(dimethylamino)-2-oxidanylidene-ethyl]-3-[4-(trifluoromethyl)phe…C14 H15 F3 N2 O22

Primary citation

Structure-guided development of a potent human B 0 AT1 inhibitor effective in a mouse model of phenylketonuria. Imazu, T., Akashi, T., Hiraizumi, M. et al. Commun Biol (2026). DOI 10.1038/s42003-026-10535-y · PubMed

Other PDB entries of the same protein (UniProt Q695T7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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