Sodium-dependent neutral amino acid transporter B(0)AT1 (SLC6A19) is a 634-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q695T7.
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The mean pLDDT of this model is 90.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 75% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:15286787, PubMed:15286788, PubMed:18424768, PubMed:18484095, PubMed:19185582, PubMed:26240152). This uptake is sodium-dependent and chloride-independent (PubMed:15286787, PubMed:15286788, PubMed:19185582). Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:18424768, PubMed:19185582)
Interacts in a tissue-specific manner with ACE2 in small intestine and with CLTRN in the kidney (By similarity). Interacts with CLTRN; this interaction is required for trafficking of SLC6A19 to the plasma membrane and for its catalytic activation in kidneys (By similarity). Interacts with ACE2; this interaction is required for trafficking of SLC6A19 to the plasma membrane and for its catalytic…
Cell membrane, Apical cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9KXW | EM | 2.66 Å | A=2-634 |
| 9KY0 | EM | 2.68 Å | A/C=2-634 |
| 9KXT | EM | 2.7 Å | A=2-634 |
| 9KXV | EM | 2.71 Å | A=2-634 |
| 9KXX | EM | 2.77 Å | A=8-620 |
| 9KXZ | EM | 2.8 Å | A/C=2-634 |
| 9KY1 | EM | 2.8 Å | A/C=2-634 |
| 9KXY | EM | 2.82 Å | A/C=2-634 |
| 9KXU | EM | 2.87 Å | A=2-634 |
| 6M17 | EM | 2.9 Å | A/C=2-634 |
| 6M18 | EM | 2.9 Å | A/C=2-634 |
| 8I93 | EM | 3.1 Å | B/D=2-633 |
| 9LSZ | EM | 3.11 Å | A=8-620 |
| 8WBY | EM | 3.18 Å | A/D=2-634 |
| 7V61 | EM | 3.2 Å | A/C=2-634 |
| 8I92 | EM | 3.2 Å | B/D=5-609 |
| 8WBZ | EM | 3.2 Å | A/D=2-634 |
| 6M1D | EM | 4.5 Å | A/C=2-634 |
| 7DWX | EM | 8.3 Å | A/C=2-634 |
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