Inward-open Structure of human B0AT1. Determined by electron microscopy at 2.77 Å resolution. Released 10 Dec 2025.
Explore 9KXX in 3D Show helices and sheets RCSB PDB PDBe
9KXX contains 41 α-helices and 6 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 18-24 | 7 | |
| α-helix | 40-47 | 8 | |
| α-helix | 52 | 1 | |
| α-helix | 53-57 | 5 | |
| α-helix | 58-63 | 6 | |
| α-helix | 68-77 | 10 | |
| α-helix | 78-82 | 5 | |
| α-helix | 83-96 | 14 | |
| α-helix | 100-107 | 8 | |
| α-helix | 109-111 | 3 | |
| α-helix | 113-141 | 29 | |
| α-helix | 153-154 | 2 | |
| β-strand | 155 | 1 | 1 |
| α-helix | 156 | 1 | |
| β-strand | 162 | 1 | 1 |
| α-helix | 164-168 | 5 | |
| α-helix | 171-174 | 4 | |
| α-helix | 175-180 | 6 | |
| β-strand | 193 | 1 | 2 |
| α-helix | 195-210 | 16 | |
| α-helix | 211-215 | 5 | |
| α-helix | 216-226 | 11 | |
| α-helix | 229-242 | 14 | |
| α-helix | 247-253 | 7 | |
| α-helix | 259-262 | 4 | |
| α-helix | 267-279 | 13 | |
| α-helix | 285-290 | 6 | |
| α-helix | 299-335 | 37 | |
| α-helix | 385-390 | 6 | |
| α-helix | 398-408 | 11 | |
| α-helix | 413-446 | 34 | |
| α-helix | 455-474 | 20 | |
| β-strand | 475 | 1 | 2 |
| α-helix | 478-489 | 12 | |
| α-helix | 492-503 | 12 | |
| α-helix | 504-508 | 5 | |
| α-helix | 511-522 | 12 | |
| α-helix | 525-527 | 3 | |
| α-helix | 528-532 | 5 | |
| α-helix | 533-537 | 5 | |
| α-helix | 538-553 | 16 | |
| β-strand | 559-562 | 4 | 3 |
| β-strand | 574-577 | 4 | 3 |
| α-helix | 578-579 | 2 | |
| α-helix | 582-586 | 5 | |
| α-helix | 587-591 | 5 | |
| α-helix | 592-607 | 16 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Sodium-dependent neutral amino acid transporter B(0)AT1 | A | protein | 614 | Homo sapiens | Q695T7 (AlphaFold model) |
>9KXX_1 Sodium-dependent neutral amino acid transporter B(0)AT1 (chains A) MNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHG GGAFMIPFLILLVLLGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGIGLASMLTSFMVG LYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRETLNISTS ISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKG ATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFASYNSVHNNCEKDSVIV SIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQR CNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFC LGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGLIFTLNSGQYWLSLLD SYAGSIPLLIIAFAEMFSVVWVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLLLIIF LFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLI RNHAQKPGDHQGLV
Structure-guided development of a potent human B 0 AT1 inhibitor effective in a mouse model of phenylketonuria. Imazu, T., Akashi, T., Hiraizumi, M. et al. Commun Biol (2026). DOI 10.1038/s42003-026-10535-y · PubMed
Other PDB entries of the same protein (UniProt Q695T7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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