9WQN: GRM1-Gq Complex Structure

GRM1-Gq Complex Structure. Determined by electron microscopy at 3.7 Å resolution. Released 27 May 2026.

Method: Electron microscopy
Resolution: 3.7 Å
Organisms: Homo sapiens, Mus musculus
Chains: 6
Atoms: 19,409
Mol. weight: 301.58 kDa
Ligands: CLR, NAG, GGL, A1EX5
Released: 27 May 2026

Explore 9WQN in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9WQN contains 96 α-helices and 113 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	7-30	24
β-strand	33-39	7	19
α-helix	46-55	10
β-strand	69-76	8	19
β-strand	79-86	8	19
α-helix	90-92	3
α-helix	96-100	5
β-strand	105-111	7	19
α-helix	118-129	12
α-helix	132-134	3
β-strand	138-144	7	19
α-helix	146-155	10
α-helix	160-162	3
α-helix	166-169	4
α-helix	178-179	2
α-helix	184-204	21
β-strand	211-215	5	19
α-helix	223-242	20

Chain B: 4 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	4-25	22
α-helix	30-33	4
α-helix	38-42	5
β-strand	47-51	5	20
β-strand	58-63	6	21
β-strand	69-74	6	21
β-strand	78-83	6	21
β-strand	88-94	7	21
β-strand	102-105	4	22
β-strand	111-115	5	22
β-strand	120-125	6	22
β-strand	135-140	6	22
β-strand	146-151	6	23
β-strand	156-161	6	23
β-strand	165-170	6	23
β-strand	175-181	7	23
β-strand	187-192	6	24
β-strand	198-203	6	24
β-strand	207-212	6	24
β-strand	218-223	6	24
β-strand	229-234	6	25
β-strand	240-245	6	25
β-strand	250-254	5	25
β-strand	259-264	6	25
α-helix	272	1
β-strand	273-277	5	26
β-strand	284-289	6	26
β-strand	293-298	6	26
β-strand	304-309	6	26
β-strand	315-320	6	20
β-strand	327-331	5	20
β-strand	335-339	5	20

Chain F: 6 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	27
β-strand	10-12	3	28
β-strand	17-25	9	27
α-helix	29-31	3
β-strand	33-39	7	28
β-strand	45-51	7	28
α-helix	53-55	3
β-strand	58-60	3	28
β-strand	69-73	5	27
β-strand	78-84	7	27
α-helix	88-90	3
β-strand	92-99	8	28
β-strand	110-111	2	28
β-strand	115-119	5	28
β-strand	140-141	2	29
β-strand	146-149	4	30
β-strand	155-161	7	29
β-strand	174-179	6	30
β-strand	185-190	6	30
β-strand	194-195	2	30
α-helix	196	1
β-strand	203-208	6	29
β-strand	211-216	6	29
α-helix	221-223	3
β-strand	225-231	7	30
α-helix	237	1
β-strand	243-247	5	30

Chain G: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	8-23	16
α-helix	30-44	15
α-helix	45-47	3
α-helix	53-55	3

Chain X: 35 helices, 29 β-strands

Element	Residues	Length	Sheet
β-strand	38-41	4	1
β-strand	45-51	7	1
β-strand	54	1	2
α-helix	55-58	4
β-strand	70	1	2
α-helix	72-76	5
α-helix	77-91	15
β-strand	101-107	7	1
α-helix	112-123	12
β-strand	156-160	5	1
α-helix	165-175	11
α-helix	176-178	3
β-strand	182-184	3	1
α-helix	190-193	4
β-strand	201-203	3	1
α-helix	208-221	14
β-strand	226-232	7	3
α-helix	235-251	17
β-strand	254-261	8	3
α-helix	267-278	12
β-strand	286-289	4	3
α-helix	293-305	13
β-strand	313-316	4	3
α-helix	331-334	4
β-strand	338-342	5	3
α-helix	348-354	7
α-helix	368-376	9
β-strand	379	1	4
β-strand	393	1	4
α-helix	394	1
α-helix	410-431	22
α-helix	440-442	3
α-helix	445-446	2
α-helix	447-455	9
β-strand	458-460	3	5
β-strand	466-468	3	5
β-strand	479-486	8	3
β-strand	492-501	10	3
β-strand	504-507	4	3
α-helix	509-511	3
α-helix	526-528	3
β-strand	532-536	5	6
β-strand	545-549	5	6
β-strand	554-556	3	7
β-strand	562-564	3	7
α-helix	565-566	2
β-strand	569-571	3	8
β-strand	578-580	3	8
α-helix	581-582	2
β-strand	584	1	9
α-helix	591-616	26
α-helix	621-624	4
α-helix	628-649	22
α-helix	654-682	29
α-helix	683-687	5
α-helix	693-695	3
α-helix	703-708	6
α-helix	711-727	17
β-strand	732-735	4	9
β-strand	743-746	4	9
α-helix	750-773	24
α-helix	784-805	22
α-helix	812-840	29
α-helix	842-844	3

Chain Y: 35 helices, 29 β-strands

Element	Residues	Length	Sheet
β-strand	39-41	3	10
β-strand	45-51	7	10
β-strand	54	1	11
α-helix	55-58	4
α-helix	59-61	3
β-strand	70	1	11
α-helix	71	1
α-helix	72-76	5
α-helix	77-91	15
β-strand	101-107	7	10
α-helix	112-123	12
β-strand	156-160	5	10
α-helix	165-175	11
β-strand	182-184	3	10
α-helix	191-193	3
β-strand	201-203	3	10
α-helix	208-221	14
β-strand	226-232	7	12
α-helix	235-250	16
β-strand	254-261	8	12
α-helix	267-278	12
β-strand	286-289	4	12
α-helix	293-306	14
β-strand	313-316	4	12
α-helix	324-327	4
α-helix	331-334	4
β-strand	338-342	5	12
α-helix	348-354	7
α-helix	368-376	9
β-strand	379	1	13
β-strand	393	1	13
α-helix	394	1
α-helix	410-431	22
α-helix	440-442	3
α-helix	445-446	2
α-helix	447-456	10
β-strand	458-460	3	14
β-strand	466-468	3	14
β-strand	479-486	8	12
β-strand	492-501	10	12
β-strand	504-507	4	12
α-helix	509-511	3
α-helix	526-528	3
β-strand	532-536	5	15
β-strand	545-549	5	15
β-strand	554-556	3	16
β-strand	562-564	3	16
α-helix	565-566	2
β-strand	569-571	3	17
β-strand	578-580	3	17
α-helix	581-583	3
β-strand	584	1	18
α-helix	591-616	26
α-helix	621-625	5
α-helix	629-649	21
α-helix	654-685	32
α-helix	706-727	22
β-strand	732-735	4	18
β-strand	743-746	4	18
α-helix	751-773	23
α-helix	783-807	25
α-helix	812-835	24
α-helix	836-840	5
α-helix	842-844	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Metabotropic glutamate receptor 1	X, Y	protein	869	Homo sapiens	Q13255 (AlphaFold model)
miniGq	A	protein	246	Homo sapiens
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	B	protein	340	Homo sapiens	P62873 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	G	protein	80	Homo sapiens	P59768 (AlphaFold model)
scFv16	F	protein	260	Mus musculus

Sequence of entity 1 (X, Y), FASTA

>9WQN_1 Metabotropic glutamate receptor 1 (chains X, Y)
DYKDDDDKTGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEA
MFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCL
PDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYF
LRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKI
YSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWA
DRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLP
GHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDA
MKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWH
EGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFT
CKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTP
VVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNR
IARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKE
VYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAF
VPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVG
DGKLPCRSNTFLNIFRRKKAGAGNANSNG

Sequence of entity 2 (A), FASTA

>9WQN_2 miniGq (chains A)
MGSTVSAEDKAAAERSKMIDKNLREDGEKARRTLRLLLLGADNSGKSTIVKQMRILHGGS
GGSGGTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVDSSDYNRLQE
ALNDFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEP
GEDPRVTRAKYFIRKEFVDISTASGDGRHICYPHFTCAVDTENARRIFNDCKDIILQMNL
REYNLV

Sequence of entity 3 (B), FASTA

>9WQN_3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains B)
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Sequence of entity 4 (G), FASTA

>9WQN_4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains G)
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAILGSAGSAGSA

Sequence of entity 5 (F), FASTA

>9WQN_5 scFv16 (chains F)
DVQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQAPEKGLEWVAYISSGSGTIYY
ADTVKGRFTISRDDPKNTLFLQMTSLRSEDTAMYYCVRSIYYYGSSPFDFWGQGTTLTVS
SGGGGSGGGGSGGGGSDIVMTQATSSVPVTPGESVSISCRSSKSLLHSNGNTYLYWFLQR
PGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTISRLEAEDVGVYYCMQHLEYPLTFG
AGTKLELKAAAASSEDLYFQ

Ligands and cofactors

ID	Name	Formula	Copies
CLR	Cholesterol	C27 H46 O	7
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	8
GGL	Gamma-L-glutamic acid	C5 H9 N O4	2
A1EX5	N-[4-(trifluoromethyl)-1,3-oxazol-2-yl]-9H-xanthene-9-carboxamide	C18 H11 F3 N2 O3	1

Water and common crystallization additives (CL) are not listed.

Primary citation

G protein selectivity in group I metabotropic glutamate receptors. Lu, Y., Wen, T., Lu, X. et al. Sci Adv (2026) 12:eaee0044-eaee0044. DOI 10.1126/sciadv.aee0044 · PubMed

Other PDB entries of the same protein (UniProt Q13255 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3KS9 1.9 Å, Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist
4OR2 2.8 Å, Human class C G protein-coupled metabotropic glutamate receptor 1 in complex with a…
9WQO 2.9 Å, GRM1-Acc State Conformation 1
27TM 3.2 Å, GRM1-Acc State Conformation 2
9WQM 3.3 Å, GRM1-Gi Complex Structure
7DGE 3.65 Å, intermediate state of class C GPCR
7DGD 3.96 Å, apo state of class C GPCR

Browse structure collections

About this viewer

MolViewer shows 9WQN directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.