Parathyroid hormone (PTH) is a 115-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01270.
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The mean pLDDT of this model is 72.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 44% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Peptide hormone secreted by parathyroid chief cells that acts as a primary endocrine regulator of extracellular calcium and phosphate homeostasis, acting primarily on bone and kidney to maintain serum calcium levels within a narrow range (PubMed:11604398, PubMed:35932760). Acts by binding and activating the G protein-coupled receptor PTH1R, engaging the receptor to activate G(s)-mediated cAMP/PKA signaling and G(q)-mediated PLC/PKC signaling (PubMed:18375760, PubMed:35932760). In bone, acts indirectly on osteoclasts by binding PTH1R on cells of the osteoblast/osteocyte lineage, where it increases expression of TNFSF11/RANKL and decreases expression of TNFRSF11B/OPG, thereby raising the…
Interacts with PTH1R (via N-terminal extracellular domain)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1ET1 | X-ray | 0.9 Å | A/B=32-65 |
| 3C4M | X-ray | 1.95 Å | C/D=46-65 |
| 8T5F | X-ray | 1.99 Å | A/B/C=32-65 |
| 8FLQ | EM | 2.55 Å | P=32-65 |
| 8HA0 | EM | 2.62 Å | P=32-65 |
| 7VVL | EM | 2.8 Å | P=32-65 |
| 7Y36 | EM | 2.8 Å | P=32-65 |
| 9JR2 | EM | 2.8 Å | P=32-65 |
| 9JR3 | EM | 2.8 Å | P=32-65 |
| 7VVM | EM | 3.2 Å | P=32-65 |
| 7VVK | EM | 3.3 Å | P=32-65 |
| 8HAO | EM | 3.76 Å | H/P=32-65 |
| 7VVN | EM | 3.8 Å | P=32-65 |
| 7VVO | EM | 4.1 Å | P=32-65 |
| 1BWX | NMR | A=32-70 | |
| 1FVY | NMR | A=32-62 | |
| 1HPH | NMR | A=32-68 | |
| 1HPY | NMR | A=32-65 | |
| 1HTH | NMR | A=32-65 | |
| 1ZWA | NMR | A=32-65 |
Showing 20 of 26 experimental structures (best resolution first).
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