Tyrosine-protein kinase Lck (LCK) is a 509-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P06239.
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The mean pLDDT of this model is 83.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 61% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells (PubMed:2470098). Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways (PubMed:2470098). Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors (PubMed:2470098). Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR-CD3 complex (PubMed:2470098). LCK then phosphorylates…
Binds to the cytoplasmic domain of cell surface receptors, such as AXL, CD2, CD4, CD5, CD8, CD44, CD45 and CD122. Also binds to effector molecules, such as PI4K, VAV1, RASA1, FYB1 and to other protein kinases including CDK1, RAF1, ZAP70 and SYK. Binds to phosphatidylinositol 3'-kinase (PI3K) from T-lymphocytes through its SH3 domain and to the tyrosine phosphorylated form of KHDRBS1/p70 through…
Cell membrane, Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1LKK | X-ray | 1.0 Å | A=122-226 |
| 2IIM | X-ray | 1.0 Å | A=59-119 |
| 8X2P | X-ray | 1.4 Å | A/B=119-226 |
| 1QPC | X-ray | 1.6 Å | A=231-509 |
| 3LCK | X-ray | 1.7 Å | A=231-501 |
| 4C3F | X-ray | 1.72 Å | A=237-501 |
| 1BHF | X-ray | 1.8 Å | A=119-226 |
| 1LCJ | X-ray | 1.8 Å | A=119-226 |
| 1LKL | X-ray | 1.8 Å | A=123-226 |
| 6PDJ | X-ray | 1.81 Å | A=225-509 |
| 1BHH | X-ray | 1.9 Å | A=119-226, B=124-226 |
| 3MPM | X-ray | 1.95 Å | A=237-501 |
| 3AC1 | X-ray | 1.99 Å | A=225-509 |
| 1QPD | X-ray | 2.0 Å | A=231-509 |
| 1QPE | X-ray | 2.0 Å | A=231-509 |
| 2OF2 | X-ray | 2.0 Å | A=231-501 |
| 2OFU | X-ray | 2.0 Å | A=229-501 |
| 2OFV | X-ray | 2.0 Å | A/B=232-498 |
| 3AD5 | X-ray | 2.0 Å | A=225-509 |
| 3BYM | X-ray | 2.0 Å | A=230-501 |
Showing 20 of 57 experimental structures (best resolution first).
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