4C3F: Lck

Structure of Lck in complex with a compound discovered by Virtual Fragment Linking. Determined by X-ray diffraction at 1.72 Å resolution. Released 23 Oct 2013.

Method: X-ray diffraction
Resolution: 1.72 Å
Organism: HOMO SAPIENS
Chains: 1
Atoms: 2,491
Mol. weight: 30.97 kDa
Ligands: 7KW
Released: 23 Oct 2013

Explore 4C3F in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4C3F contains 18 α-helices and 10 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 18 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	239	1	1
α-helix	242-244	3
β-strand	245-254	10	1
β-strand	257-264	8	1
β-strand	268-275	8	1
α-helix	276	1
α-helix	282-294	13
β-strand	300	1	2
α-helix	301-302	2
β-strand	303-307	5	1
α-helix	312	1
β-strand	313-317	5	1
β-strand	323	1	2
α-helix	324-327	4
α-helix	331-334	4
α-helix	338-357	20
α-helix	367-369	3
β-strand	370-372	3	2
β-strand	378-380	3	2
α-helix	409-414	6
α-helix	419-434	16
α-helix	438-439	2
α-helix	446-454	9
α-helix	459-462	4
α-helix	467-476	10
α-helix	481-483	3
α-helix	485-486	2
α-helix	487-495	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Tyrosine-protein kinase lck	A	protein	267	HOMO SAPIENS	P06239 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4C3F_1 TYROSINE-PROTEIN KINASE LCK (chains A)
GPEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQ
LQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAF
IEERNYIHRNLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINY
GTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMR
LCWKERPEDRPTFDYLRSVLEDFFTAT

Ligands and cofactors

ID	Name	Formula	Copies
7KW	N-phenyl-4-(5-phenyl-1H-pyrazol-4-yl)pyrimidin-2-amine	C19 H15 N5	1

Primary citation

Efficient search of chemical space: navigating from fragments to structurally diverse chemotypes. Wassermann, A.M., Kutchukian, P.S., Lounkine, E. et al. J Med Chem (2013) 56:8879-8891. DOI 10.1021/jm401309q · PubMed

Other PDB entries of the same protein (UniProt P06239 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1LKK 1.0 Å, Human P56-lck tyrosine kinase SH2 domain in complex with the phosphotyrosyl peptide…
2IIM 1.0 Å, SH3 Domain of Human Lck
8X2P 1.4 Å, The Crystal Structure of LCK from Biortus.
1QPC 1.6 Å, Structural analysis of the lymphocyte-specific kinase lck in complex with non-selective…
3LCK 1.7 Å, The kinase domain of human lymphocyte kinase (LCK), activated form (auto-phosphorylated…
1BHF 1.8 Å, P56LCK SH2 domain inhibitor complex
1LCJ 1.8 Å, SH2 (src homology-2) domain of human P56-lck tyrosine kinase complexed with the 11…
1LKL 1.8 Å, Human P56-lck tyrosine kinase SH2 domain in complex with the phosphotyrosyl peptide…
6PDJ 1.81 Å, Tyrosine-protein kinase LCK bound to Compound 11
1BHH 1.9 Å, Free P56LCK SH2 domain
3MPM 1.95 Å, LCK complexed with a pyrazolopyrimidine
3AC1 1.99 Å, Crystal structure of pyrazin derivative bound to the kinase domain of Human LCK,…

Browse structure collections

About this viewer

MolViewer shows 4C3F directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.