1BHH: Free P56LCK SH2 domain

Name: PDB 1BHH: Free P56LCK SH2 domain
Published: 1998-10-21
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: sh2 domain

Free P56LCK SH2 domain. Determined by X-ray diffraction at 1.9 Å resolution. Released 21 Oct 1998.

Method: X-ray diffraction
Resolution: 1.9 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,808
Mol. weight: 24 kDa
Released: 21 Oct 1998

Explore 1BHH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1BHH contains 5 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	128-129	2	1
α-helix	134-142	9
β-strand	151-156	6	1
β-strand	159-171	13	1
β-strand	175-183	9	1
β-strand	184-185	2	2
β-strand	191-192	2	2
β-strand	199	1	2
α-helix	202-211	10
β-strand	223	1	1

Chain B: 3 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	128	1	3
α-helix	134-141	8
β-strand	144	1	4
β-strand	146	1	4
β-strand	151-155	5	3
β-strand	163-171	9	3
β-strand	175-183	9	3
β-strand	184-185	2	5
β-strand	191-192	2	5
β-strand	199	1	5
α-helix	202-210	9
β-strand	223	1	3
α-helix	224-225	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
T-lymphocyte-specific protein tyrosine kinase P56LCK	A	protein	108	Homo sapiens	P06239 (AlphaFold model)
P56 lck tyrosine kinase SH2 domain	B	protein	103	Homo sapiens	P06239 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1BHH_1 T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK (chains A)
ANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVV
KHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQT

Sequence of entity 2 (B), FASTA

>1BHH_2 P56 LCK TYROSINE KINASE SH2 DOMAIN (chains B)
PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI
RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQT

Primary citation

Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding. Tong, L., Warren, T.C., Lukas, S. et al. J Biol Chem (1998) 273:20238-20242. DOI 10.1074/jbc.273.32.20238 · PubMed

Other PDB entries of the same protein (UniProt P06239 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1LKK 1.0 Å, Human P56-lck tyrosine kinase SH2 domain in complex with the phosphotyrosyl peptide…
2IIM 1.0 Å, SH3 Domain of Human Lck
8X2P 1.4 Å, The Crystal Structure of LCK from Biortus.
1QPC 1.6 Å, Structural analysis of the lymphocyte-specific kinase lck in complex with non-selective…
3LCK 1.7 Å, The kinase domain of human lymphocyte kinase (LCK), activated form (auto-phosphorylated…
4C3F 1.72 Å, Structure of Lck in complex with a compound discovered by Virtual Fragment Linking
1BHF 1.8 Å, P56LCK SH2 domain inhibitor complex
1LCJ 1.8 Å, SH2 (src homology-2) domain of human P56-lck tyrosine kinase complexed with the 11…
1LKL 1.8 Å, Human P56-lck tyrosine kinase SH2 domain in complex with the phosphotyrosyl peptide…
6PDJ 1.81 Å, Tyrosine-protein kinase LCK bound to Compound 11
3MPM 1.95 Å, LCK complexed with a pyrazolopyrimidine
3AC1 1.99 Å, Crystal structure of pyrazin derivative bound to the kinase domain of Human LCK,…

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