DNA excision repair protein ERCC-1 (ERCC1) is a 297-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P07992.
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The mean pLDDT of this model is 76.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4
Heterodimer composed of ERCC1 isoform 1 and ERCC4/XPF (PubMed:16076955, PubMed:16338413, PubMed:24036546, PubMed:25538220, PubMed:32034146). Interacts with USP45 (PubMed:25538220)
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2A1I | X-ray | 1.9 Å | A=96-227 |
| 2A1J | X-ray | 2.7 Å | B=220-296 |
| 9QEC | EM | 2.9 Å | B=1-297 |
| 9QED | EM | 3.2 Å | B=1-297 |
| 9PD3 | EM | 3.3 Å | R=1-295 |
| 9PD4 | EM | 3.4 Å | R=1-295 |
| 9QEE | EM | 3.4 Å | B=1-297 |
| 6SXA | EM | 3.6 Å | G=1-297 |
| 9PCP | EM | 4.3 Å | R=1-297 |
| 6SXB | EM | 7.9 Å | G=1-297 |
| 1Z00 | NMR | A=220-297 | |
| 2JNW | NMR | A=96-214 | |
| 2JPD | NMR | A=96-219 | |
| 2MUT | NMR | A=220-297 |
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