C-C motif chemokine 3 (CCL3) is a 92-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10147.
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The mean pLDDT of this model is 88.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 64% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)
Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69) (PubMed:12070155). Interacts with CCR1 (PubMed:15905581)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3FPU | X-ray | 1.76 Å | B=24-92 |
| 2X6G | X-ray | 2.18 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=23-92 |
| 5COR | X-ray | 2.55 Å | A/B/C/D/E/F/G/H/I/J=23-92 |
| 4RA8 | X-ray | 2.6 Å | A/B/C/D/E=23-91 |
| 7F1T | X-ray | 2.6 Å | A=24-92 |
| 2X69 | X-ray | 2.65 Å | A/B/C/D/E=23-92 |
| 3KBX | X-ray | 2.65 Å | A/B/C/D/E=23-92 |
| 4ZKB | X-ray | 2.9 Å | B=24-92 |
| 7F1Q | EM | 2.9 Å | R=24-92 |
| 3H44 | X-ray | 3.0 Å | C/D=23-92 |
| 5D65 | X-ray | 3.1 Å | A/B/C/D/E=23-92 |
| 1B50 | NMR | A/B=24-92 | |
| 1B53 | NMR | A/B=24-92 |
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