Kinesin-like protein KIF11 (KIF11) is a 1056-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P52732.
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The mean pLDDT of this model is 74.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 17% |
| 70 to 90 | Confident: backbone generally right | 53% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769)
Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts (via C-terminus) with the kinase NEK6 in both interphase and mitosis. Interacts with RARRES1 and AGBL2 (PubMed:21303978). Interacts with TPX2 (PubMed:37728657)
Cytoplasm, Cytoplasm, cytoskeleton, spindle pole
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6TIW | EM | 1.09 Å | K=1-369 |
| 3ZCW | X-ray | 1.69 Å | A=16-363 |
| 6TLE | X-ray | 1.75 Å | A/B=2-368 |
| 1X88 | X-ray | 1.8 Å | A/B=10-368 |
| 6G6Y | X-ray | 1.8 Å | A=1-368 |
| 2PG2 | X-ray | 1.85 Å | A/B=1-368 |
| 1Q0B | X-ray | 1.9 Å | A/B=2-368 |
| 2X7C | X-ray | 1.9 Å | A/B=1-368 |
| 8YHH | X-ray | 1.95 Å | A/B=1-368 |
| 3K5E | X-ray | 1.97 Å | A/B=1-368 |
| 2WOG | X-ray | 2.0 Å | A/B/C=1-368 |
| 3L9H | X-ray | 2.0 Å | A/B=1-368 |
| 5JV3 | X-ray | 2.01 Å | A/B/C/D=366-391 |
| 1II6 | X-ray | 2.1 Å | A/B=1-368 |
| 2FME | X-ray | 2.1 Å | A/B=1-368 |
| 2UYI | X-ray | 2.1 Å | A/B=1-368 |
| 2UYM | X-ray | 2.11 Å | A/B=1-368 |
| 3HQD | X-ray | 2.19 Å | A/B=1-369 |
| 2X2R | X-ray | 2.2 Å | A/B/C=1-368 |
| 5ZO8 | X-ray | 2.2 Å | A/B=17-369 |
Showing 20 of 62 experimental structures (best resolution first).
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