Q14896: Myosin-binding protein C, cardiac-type (MYBPC3)

Myosin-binding protein C, cardiac-type (MYBPC3) is a 1274-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14896.

Gene: MYBPC3
Organism: Homo sapiens
Length: 1274 residues
Mean pLDDT: 78.8
Model: AF-Q14896-F1 v6
Model created: 1 Aug 2025
PDB structures: 17

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Model confidence (pLDDT)

The mean pLDDT of this model is 78.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT band	Meaning	Share of residues
Above 90	Very high: backbone and side chains are usually accurate	35%
70 to 90	Confident: backbone generally right	44%
50 to 70	Low: treat with caution	6%
Below 50	Very low: often disordered regions	14%

What pLDDT means and how to read it

Function

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role

Disease associations

Cardiomyopathy, familial hypertrophic, 4 (CMH4)
Cardiomyopathy, dilated, 1MM (CMD1MM)
Left ventricular non-compaction 10 (LVNC10)

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB ID	Method	Resolution	Chains and residues
3CX2	X-ray	1.3 Å	A=151-258
2V6H	X-ray	1.55 Å	A=151-258
7LRG	EM	6.1 Å	G/H/I/J/K/L=358-451
8G4L	EM	6.4 Å	ao/bo/o=1-1274
7TIJ	EM	8.0 Å	G/H/I/J/K/L=151-370
7TIT	EM	8.0 Å	G/H/I/J/K/L=151-370
7TJ7	EM	8.0 Å	G/H/I/J/K/L/M/N/O/P/Q/R=151-370
6G2T	EM	9.0 Å	G/H/I/J/K/L=151-258
6CXI	EM	11.0 Å	G/H/I/J/K/L=151-258, M/N/O/P/Q=1-101
6CXJ	EM	11.0 Å	G/H/I/J/K/L=151-258, M/N/O/P/Q=1-101
1GXE	NMR		A=641-770
1PD6	NMR		A=358-451
2AVG	NMR		A=151-260
2K1M	NMR		A=2-96
2MQ0	NMR		A=453-543
2MQ3	NMR		A=453-543
5K6P	NMR		A=319-451

More AlphaFold highlights

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