Splicing factor 3A subunit 1 (SF3A1) is a 793-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15459.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 66.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 39% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 30% |
What pLDDT means and how to read it
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E'…
Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins (PubMed:32494006, PubMed:36797247). Part of the SF3A subcomplex of the 17S U2 SnRNP complex which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62 and SF3A1/SAP114 (PubMed:10882114, PubMed:11533230, PubMed:21349847). SF3A associates with the…
Nucleus, Nucleus speckle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7P0V | X-ray | 1.56 Å | A=704-793 |
| 8ID2 | X-ray | 1.8 Å | A/B=703-793 |
| 7EVO | EM | 2.5 Å | A=1-793 |
| 8H6L | EM | 2.6 Å | 2D=1-793 |
| 8H6K | EM | 2.7 Å | 2D=1-793 |
| 8HK1 | EM | 2.7 Å | A=1-793 |
| 7VPX | EM | 3.0 Å | A=1-793 |
| 8I0R | EM | 3.0 Å | u=1-793 |
| 8I0T | EM | 3.0 Å | u=1-793 |
| 8Q7N | EM | 3.1 Å | 7=1-793 |
| 8QOZ | EM | 3.1 Å | 7=1-793 |
| 8QPE | EM | 3.1 Å | 7=1-793 |
| 8H6E | EM | 3.2 Å | 2D=1-793 |
| 8H6J | EM | 3.25 Å | 2D=1-793 |
| 6QX9 | EM | 3.28 Å | A1=1-793 |
| 8I0P | EM | 3.4 Å | u=1-793 |
| 8QP8 | EM | 3.5 Å | 7=1-793 |
| 9ZEC | EM | 3.61 Å | A1=1-793 |
| 8QPA | EM | 3.7 Å | 7=1-793 |
| 8QPB | EM | 3.7 Å | 7=1-793 |
Showing 20 of 48 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.