Negative elongation factor C/D (NELFCD) is a 590-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8IXH7.
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The mean pLDDT of this model is 86.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401)
The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE; NELFA and NELFCD form a stable subcomplex that binds primarily through NELFCD to the N-terminus of NELFB (PubMed:12612062, PubMed:27282391). Binds RNA which may help to stabilize the NELF complex on nucleic acid (PubMed:27282391). In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8UHG | EM | 2.7 Å | W=1-590 |
| 8UI0 | EM | 2.7 Å | W=1-590 |
| 8JJ6 | X-ray | 2.72 Å | C/D=36-182 |
| 5L3X | X-ray | 2.75 Å | B=186-590 |
| 8UHD | EM | 2.8 Å | W=1-590 |
| 6GML | EM | 3.2 Å | W=10-590 |
| 8UIS | EM | 3.23 Å | W=1-590 |
| 9J0O | EM | 3.3 Å | W=1-590 |
| 9J0P | EM | 3.3 Å | W=1-590 |
| 9J0N | EM | 3.4 Å | W=1-590 |
| 8UHA | EM | 3.5 Å | W=1-590 |
| 7PKS | EM | 3.6 Å | W=1-590 |
| 8W8E | EM | 3.9 Å | W=10-590 |
| 8RBX | EM | 4.1 Å | w=10-590 |
| 7YCX | EM | 4.18 Å | g=1-590 |
| 9VD9 | EM | 4.6 Å | g=1-590 |
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