Tumor protein 63 (TP63) is a 680-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H3D4.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 63.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 35% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 43% |
What pLDDT means and how to read it
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the…
Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2Y9U | X-ray | 1.6 Å | A=545-611 |
| 8P9C | X-ray | 1.76 Å | A=397-455 |
| 7Z72 | X-ray | 1.8 Å | A=545-611 |
| 7Z7E | X-ray | 1.8 Å | A=162-363 |
| 7Z71 | X-ray | 1.85 Å | A/C=162-363 |
| 3ZY0 | X-ray | 1.9 Å | A/B/C/D=398-427 |
| 6RU8 | X-ray | 1.92 Å | E/F/G/H=621-632 |
| 6RU6 | X-ray | 2.05 Å | C=618-630 |
| 6RU7 | X-ray | 2.08 Å | C/D=618-633 |
| 3ZY1 | X-ray | 2.15 Å | A=398-441 |
| 9N54 | X-ray | 2.2 Å | A=372-396 |
| 8P9E | X-ray | 2.25 Å | A=397-455 |
| 7Z73 | X-ray | 2.27 Å | A/B/C/D=397-455 |
| 4A9Z | X-ray | 2.29 Å | A/B/C/D=397-455 |
| 9GFO | X-ray | 2.4 Å | AAA/BBB/CCC/DDD=373-381 |
| 3QYN | X-ray | 2.5 Å | A/B/C/D=166-362 |
| 3US0 | X-ray | 2.5 Å | A/B/C/D=166-362 |
| 8P9D | X-ray | 2.7 Å | A/C=397-455 |
| 3US1 | X-ray | 2.8 Å | A/D=166-362 |
| 3QYM | X-ray | 3.2 Å | A/B/C/D/E/F/G/H=166-362 |
Showing 20 of 26 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.