Cell division cycle protein 23 homolog (CDC23) is a 597-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UJX2.
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The mean pLDDT of this model is 84.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:18485873, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the…
Homodimer (PubMed:27120157, PubMed:27509861). Component of the anaphase promoting complex/cyclosome (APC/C), composed of ANAPC1, ANAPC2, CDC27/ANAPC3, ANAPC4, ANAPC5, CDC16/ANAPC6, ANAPC7, CDC23/ANAPC8, ANAPC10, ANAPC11, CDC26/ANAPC12, ANAPC13, ANAPC15 and ANAPC16 (PubMed:25043029, PubMed:26083744, PubMed:27120157, PubMed:27509861). APC/C associates with CDC20 to form the CDC20-APC/C complex,…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9GAW | EM | 2.9 Å | U/V=1-597 |
| 6Q6G | EM | 3.2 Å | U/V=1-597 |
| 6Q6H | EM | 3.2 Å | U/V=1-597 |
| 8PKP | EM | 3.2 Å | U/V=1-597 |
| 5G05 | EM | 3.4 Å | C/P=1-597 |
| 8TAU | EM | 3.5 Å | U/V=1-597 |
| 4UI9 | EM | 3.6 Å | C/P=7-597 |
| 6TNT | EM | 3.78 Å | C/P=1-597 |
| 6TLJ | EM | 3.8 Å | C/P=1-597 |
| 6TM5 | EM | 3.9 Å | C/P=1-597 |
| 9N9R | EM | 3.9 Å | U/V=1-597 |
| 9N9S | EM | 3.9 Å | U/V=1-597 |
| 5G04 | EM | 4.0 Å | C/P=1-597 |
| 5LCW | EM | 4.0 Å | C/P=1-597 |
| 8TAR | EM | 4.0 Å | U/V=1-597 |
| 5A31 | EM | 4.3 Å | C/P=1-597 |
| 5KHU | EM | 4.8 Å | C/P=1-597 |
| 5KHR | EM | 6.1 Å | C/P=1-597 |
| 5L9T | EM | 6.4 Å | C/P=1-597 |
| 5L9U | EM | 6.4 Å | C/P=1-597 |
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