1Z19: Lambda integrase(75-356) dimer

Crystal structure of a lambda integrase(75-356) dimer bound to a COC' core site. Determined by X-ray diffraction at 2.8 Å resolution. Released 28 Jun 2005.

Method
X-ray diffraction
Resolution
2.8 Å
Organism
Enterobacteria phage lambda
Chains
5
Atoms
5,677
Mol. weight
85.74 kDa
Released
28 Jun 2005

Explore 1Z19 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1Z19 contains 39 α-helices and 21 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 20 helices, 9 β-strands

ElementResiduesLengthSheet
β-strand7511
α-helix76-8914
α-helix94-11017
β-strand11511
α-helix116-1183
α-helix121-13313
α-helix137-15620
α-helix169-1724
α-helix177-1793
α-helix182-19110
α-helix192-1943
α-helix197-20812
α-helix213-2164
β-strand22012
α-helix221-2233
β-strand224-22523
β-strand228-23253
β-strand239-24353
β-strand247-24824
β-strand253-25424
α-helix255-2617
α-helix262-2665
β-strand27012
α-helix279-2813
α-helix282-29514
α-helix304-3052
α-helix307-3093
α-helix310-32112
α-helix324-3318
Chain B: 19 helices, 12 β-strands
ElementResiduesLengthSheet
β-strand7515
α-helix76-8712
α-helix94-11017
β-strand11515
α-helix116-1183
α-helix121-13313
α-helix137-15620
α-helix170-1723
β-strand17716
α-helix178-1792
α-helix182-19110
α-helix192-1943
α-helix198-20912
α-helix213-2164
β-strand22017
α-helix221-2233
β-strand224-22528
β-strand228-23258
β-strand239-24358
β-strand247-24829
β-strand253-25429
α-helix255-26511
β-strand27017
α-helix282-29615
β-strand30316
α-helix304-3052
α-helix307-3093
α-helix310-32112
α-helix324-3307
α-helix336-3427
β-strand351-35223

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
5'-d(*cp*tp*cp*gp*tp*tp*cp*ap*gp*cp*tp*tp*tp*tp*tp*t)-3'CDNA16
5'-d(p*tp*tp*tp*ap*tp*ap*cp*tp*ap*ap*gp*tp*tp*gp*gp*cp*ap*tp*tp*a)-3'DDNA20
33-MEREDNA33
IntegraseA, Bprotein283Enterobacteria phage lambdaP03700
Sequence of entity 1 (C), FASTA
>1Z19_1 5'-D(*CP*TP*CP*GP*TP*TP*CP*AP*GP*CP*TP*TP*TP*TP*TP*T)-3' (chains C)
CTCGTTCAGCTTTTTT
Sequence of entity 2 (D), FASTA
>1Z19_2 5'-D(P*TP*TP*TP*AP*TP*AP*CP*TP*AP*AP*GP*TP*TP*GP*GP*CP*AP*TP*TP*A)-3' (chains D)
TTTATACTAAGTTGGCATTA
Sequence of entity 3 (E), FASTA
>1Z19_3 33-MER (chains E)
TAATGCCAACTTAGTATAAAAAAGCTGAACGAG
Sequence of entity 4 (A, B), FASTA
>1Z19_4 Integrase (chains A, B)
MTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDITTKEIAAMLNGYID
EGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSKVRRSRLTADEYLKIYQAAE
SSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKIAIPTALHIDALGI
SMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSL
SARLYEKQISDKFAQHLLGHKSDTMASQYRDDRGREWDKIEIK

Primary citation

A structural basis for allosteric control of DNA recombination by lambda integrase. Biswas, T., Aihara, H., Radman-Livaja, M. et al. Nature (2005) 435:1059-1066. DOI 10.1038/nature03657 · PubMed

Other PDB entries of the same protein (UniProt P03700), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 1Z19 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.