1Z1B: Lambda integrase dimer

Crystal structure of a lambda integrase dimer bound to a COC' core site. Determined by X-ray diffraction at 3.8 Å resolution. Released 28 Jun 2005.

Method
X-ray diffraction
Resolution
3.8 Å
Organism
Enterobacteria phage lambda
Chains
7
Atoms
7,653
Mol. weight
115.57 kDa
Released
28 Jun 2005

Explore 1Z1B in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1Z1B contains 42 α-helices and 27 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 19 helices, 15 β-strands

ElementResiduesLengthSheet
β-strand16-1941
β-strand23-2751
β-strand34-3851
α-helix41-5717
α-helix64-729
β-strand7512
α-helix76-8813
α-helix94-11017
β-strand11512
α-helix116-1183
α-helix121-13313
α-helix137-15620
β-strand17713
α-helix178-1792
α-helix182-19110
α-helix197-20913
α-helix213-2164
β-strand22014
α-helix221-2233
β-strand224-22525
β-strand228-23255
β-strand239-24355
β-strand247-24826
β-strand253-25426
α-helix255-2617
α-helix262-2665
β-strand27014
α-helix282-29615
β-strand30313
α-helix304-3052
α-helix309-32113
α-helix324-3318
α-helix336-3427
β-strand351-35227
Chain B: 23 helices, 12 β-strands
ElementResiduesLengthSheet
α-helix12-132
β-strand16-1838
β-strand24-2748
β-strand34-3858
α-helix41-5515
α-helix63-697
α-helix70-723
β-strand7519
α-helix76-8914
α-helix94-11017
β-strand11519
α-helix116-1183
α-helix121-13313
α-helix137-15620
α-helix170-1723
α-helix182-19110
α-helix192-1943
α-helix197-20913
α-helix213-2164
β-strand220110
α-helix221-2233
β-strand224-22527
β-strand228-23257
β-strand239-24357
β-strand247-248211
β-strand253-254211
α-helix255-2617
α-helix262-2665
β-strand270110
α-helix279-2813
α-helix282-29615
α-helix304-3052
α-helix309-32113
α-helix324-3318
α-helix339-3424

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
5'-d(*cp*t*cp*gp*tp*tp*cp*ap*gp*cp*tp*tp*tp*tp*tp*t)-3'CDNA14
5'-d(*tp*tp*tp*ap*tp*ap*cp*tp*ap*ap*gp*tp*tp*gp*gp*cp*ap*t)-3'DDNA18
29-mer DNAEDNA29
26-mer DNAFDNA26
26-mer DNAGDNA26
IntegraseA, Bprotein356Enterobacteria phage lambdaP03700
Sequence of entity 1 (C), FASTA
>1Z1B_1 5'-D(*CP*T*CP*GP*TP*TP*CP*AP*GP*CP*TP*TP*TP*TP*TP*T)-3' (chains C)
CGTTCAGCTTTTTT
Sequence of entity 2 (D), FASTA
>1Z1B_2 5'-D(*TP*TP*TP*AP*TP*AP*CP*TP*AP*AP*GP*TP*TP*GP*GP*CP*AP*T)-3' (chains D)
TTTATACTAAGTTGGCAT
Sequence of entity 3 (E), FASTA
>1Z1B_3 29-MER DNA (chains E)
ATGCCAACTTAGTATAAAAAAGCTGAACG
Sequence of entity 4 (F), FASTA
>1Z1B_4 26-MER DNA (chains F)
ACAGGTCACTATCAGTCAAAATACCG
Sequence of entity 5 (G), FASTA
>1Z1B_5 26-MER DNA (chains G)
CGGTATTTTGACTGATAGTGACCTGT
Sequence of entity 6 (A, B), FASTA
>1Z1B_6 Integrase (chains A, B)
MGRRRSHERRDLPPNLYIRNNGYYCYRDPRTGKEFGLGRDRRIAITEAIQANIELFSGHK
HKPLTARINSDNSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDIT
TKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSKVRRSRL
TADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKI
AIPTALHIDALGISMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSF
EGDPPTFHELRSLSARLYEKQISDKFAQHLLGHKSDTMASQYRDDRGREWDKIEIK

Primary citation

A structural basis for allosteric control of DNA recombination by lambda integrase. Biswas, T., Aihara, H., Radman-Livaja, M. et al. Nature (2005) 435:1059-1066. DOI 10.1038/nature03657 · PubMed

Other PDB entries of the same protein (UniProt P03700), best resolution first:

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