1Z1G: Lambda integrase tetramer

Crystal structure of a lambda integrase tetramer bound to a Holliday junction. Determined by X-ray diffraction at 4.4 Å resolution. Released 28 Jun 2005.

Method

X-ray diffraction

Resolution

4.4 Å

Organism

Enterobacteria phage lambda

Chains

12

Atoms

15,156

Mol. weight

229.29 kDa

Released

28 Jun 2005

Explore 1Z1G in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1Z1G contains 76 α-helices and 47 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 20 helices, 11 β-strands

Molecules and chains

>1Z1G_1 29-MER (chains I)
AACTCTGCTTTTTACAACAAAGTTGGATC

>1Z1G_2 29-MER (chains J)
CGCTCAAGTTTATATTAAAAAGCAGAGTT

>1Z1G_3 29-MER (chains K)
TTGCCAGCTTTATTATATAAACTTGAGCG

>1Z1G_4 29-MER (chains L)
GATCCAACTTTGTTGAATAAAGCTGGCAA

>1Z1G_5 5'-D(*AP*CP*AP*GP*GP*TP*CP*AP*CP*TP*AP*TP*CP*AP*GP*TP*CP*AP*AP*AP*AP*TP*AP*CP*C)-3' (chains E, G)
ACAGGTCACTATCAGTCAAAATACC

>1Z1G_6 25-MER (chains F, H)
GGTATTTTGACTGATAGTGACCTGT

>1Z1G_7 Integrase (chains A, B, C, D)
MGRRRSHERRDLPPNLYIRNNGYYCYRDPRTGKEFGLGRDRRIAITEAIQANIELFSGHK
HKPLTARINSDNSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDIT
TKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSEVRRSRL
TADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKI
AIPTALHIDALGISMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSF
EGDPPTFHELRSLSARLYEKQISDKFAQHLLGHKSDTMASQFRDDRGREWDKIEIK

Primary citation

A structural basis for allosteric control of DNA recombination by lambda integrase. Biswas, T., Aihara, H., Radman-Livaja, M. et al. Nature (2005) 435:1059-1066. DOI 10.1038/nature03657 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P03700), best resolution first:

• 1AE9 1.9 Å, Structure of the lambda integrase catalytic core
• 2OXO 2.0 Å, Crystallization and structure determination of the core-binding domain of bacteriophage…
• 1Z19 2.8 Å, Crystal structure of a lambda integrase(75-356) dimer bound to a COC' core site
• 1P7D 2.95 Å, Crystal structure of the Lambda Integrase (residues 75-356) bound to DNA
• 1Z1B 3.8 Å, Crystal structure of a lambda integrase dimer bound to a COC' core site
• 5J0N 11.0 Å, Lambda excision HJ intermediate
• 1KJK Solution structure of the lambda integrase amino-terminal domain
• 2WCC phage lambda IntDBD1-64 complex with p prime 2 DNA

Browse structure collections

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