2H2C: ZO-1 PDZ1

Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTWV). Determined by X-ray diffraction at 2.0 Å resolution. Released 13 Jun 2006.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Homo sapiens
Chains: 1
Atoms: 868
Mol. weight: 11.73 kDa
Released: 13 Jun 2006

Explore 2H2C in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2H2C contains 1 α-helix and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	15-27	13	1
β-strand	29	1	2
β-strand	33	1	2
β-strand	36-39	4	1
β-strand	55-59	5	1
β-strand	73-78	6	1
β-strand	81-82	2	1
α-helix	88-96	9
β-strand	101-112	12	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Tight junction protein ZO-1	A	protein	107	Homo sapiens	Q07157 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2H2C_1 Tight junction protein ZO-1 (chains A)
GSHMIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQEND
RVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKGGGWRRTTWV

Primary citation

Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity. Appleton, B.A., Zhang, Y., Wu, P. et al. J Biol Chem (2006) 281:22312-22320. DOI 10.1074/jbc.M602901200 · PubMed

Other PDB entries of the same protein (UniProt Q07157 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4Q2Q 1.45 Å, ZO1 PDZ3 in Complex with a Phage-Derived Peptide
2H2B 1.6 Å, Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTYL)
2RCZ 1.7 Å, Structure of the second PDZ domain of ZO-1
9HM2 1.72 Å, A swapped dimeric form of ZO1/TJP1 PDZ2 in complex with the C-terminal peptide from…
4YYX 1.79 Å, Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin2 C-terminal…
4OEO 1.9 Å, High resolution crystal structure of the unliganded ZO-1 PDZ1 domain
3TSV 1.99 Å, crystal structure of the third PDZ domain of the human ZO-1 MAGUK protein
4OEP 2.35 Å, Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal…
3CYY 2.4 Å, The crystal structure of ZO-1 PDZ2 in complex with the Cx43 peptide
3TSZ 2.5 Å, crystal structure of PDZ3-SH3-GUK core module from human ZO-1 in complex with 12mer…
3LH5 2.6 Å, Crystal Structure of the SH3-Guanylate kinase core domain of ZO-1
3SHU 2.75 Å, Crystal structure of ZO-1 PDZ3

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