5BQ8: Norrin

Crystal structure of Norrin, a Wnt signalling activator, Crystal Form II. Determined by X-ray diffraction at 2.0 Å resolution. Released 1 Jul 2015.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Homo sapiens
Chains: 4
Atoms: 3,319
Mol. weight: 54.97 kDa
Released: 1 Jul 2015

Explore 5BQ8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5BQ8 contains 6 α-helices and 36 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 10 β-strands

Element	Residues	Length	Sheet
β-strand	40-48	9	1
β-strand	55	1	2
β-strand	58-67	10	1
α-helix	72	1
β-strand	73-77	5	3
β-strand	80-81	2	4
β-strand	84	1	4
β-strand	89-92	4	3
β-strand	94-109	16	5
β-strand	110	1	2
β-strand	115-130	16	5

Chain B: 2 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	40-48	9	3
β-strand	55-56	2	4
β-strand	58-67	10	3
α-helix	72	1
β-strand	73-77	5	1
α-helix	78-79	2
β-strand	80-81	2	5
β-strand	84	1	5
β-strand	89-92	4	1
β-strand	94-110	17	4
β-strand	114-130	17	4

Chain C: 2 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	40-48	9	6
β-strand	55	1	7
β-strand	58-67	10	6
α-helix	72	1
β-strand	73-77	5	8
α-helix	78-79	2
β-strand	80-81	2	9
β-strand	84	1	9
β-strand	89-92	4	8
β-strand	94-110	17	7
β-strand	114-130	17	7

Chain D: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	40-50	11	8
β-strand	53-67	15	8
α-helix	72	1
β-strand	73-77	5	6
β-strand	80-81	2	7
β-strand	84	1	7
β-strand	89-92	4	6
β-strand	94-110	17	9
β-strand	114-130	17	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Norrin	A, C	protein	122	Homo sapiens	Q00604 (AlphaFold model)
Norrin	B	protein	122	Homo sapiens	Q00604 (AlphaFold model)
Norrin	D	protein	122	Homo sapiens	Q00604 (AlphaFold model)

Sequence of entity 1 (A, C), FASTA

>5BQ8_1 Norrin (chains A, C)
GPGKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSF
STVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNSGTETSQVA
PA

Sequence of entity 2 (B), FASTA

>5BQ8_2 Norrin (chains B)
GPGKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSF
STVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNSGTETSQVA
PA

Sequence of entity 3 (D), FASTA

>5BQ8_3 Norrin (chains D)
GPGKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSF
STVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNSGTETSQVA
PA

Primary citation

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan. Chang, T.H., Hsieh, F.L., Zebisch, M. et al. Elife (2015) 4:e06554. DOI 10.7554/eLife.06554 · PubMed

Other PDB entries of the same protein (UniProt Q00604 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5BQB 2.3 Å, Crystal structure of Norrin, a Wnt signalling activator, Crystal Form III
5BQE 2.3 Å, Crystal structure of Norrin in complex with the cysteine-rich domain of Frizzled 4…
5BPU 2.4 Å, Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I
5BQC 3.0 Å, Crystal structure of Norrin in complex with the cysteine-rich domain of Frizzled 4 and…
9UOK 3.05 Å, Structure of the complex of LGR4_ECD with Norrin
8WVY 3.29 Å, Cryo-EM structure of LGR4 in complex with Norrin
8WVX 3.32 Å, Cryo-EM structure of LGR4 in complex with Norrin(dimer)
9KHH 3.65 Å, Structure of the complex of LGR4 with Norrin (2:2)
9MAN 3.78 Å, Structure of Norrin in complex with human Tspan12 large extracellular loop (Tspan12 LEL)
5CL1 3.8 Å, Complex structure of Norrin with human Frizzled 4

Browse structure collections

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