6M1D: ACE2-B0AT1 complex, open conformation

ACE2-B0AT1 complex, open conformation. Determined by electron microscopy at 4.5 Å resolution. Released 11 Mar 2020.

Method
Electron microscopy
Resolution
4.5 Å
Organism
Homo sapiens
Chains
4
Atoms
21,776
Mol. weight
334.09 kDa
Released
11 Mar 2020

Explore 6M1D in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6M1D contains 155 α-helices and 41 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and C: 35 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix21-244
α-helix39-4911
α-helix58-625
α-helix71-777
α-helix78-825
α-helix83-9614
α-helix100-1067
α-helix114-14128
β-strand15511
β-strand16211
α-helix164-1685
α-helix171-1744
α-helix175-1806
α-helix195-21117
α-helix215-2217
α-helix229-24315
α-helix259-2613
α-helix265-27814
α-helix285-2895
α-helix300-34748
α-helix360-37011
α-helix374-3763
α-helix3971
α-helix398-4025
α-helix403-4075
α-helix413-43018
α-helix434-4407
α-helix455-4639
α-helix469-4746
α-helix478-48710
α-helix493-50311
α-helix504-5107
α-helix511-52111
α-helix528-5325
α-helix533-5375
α-helix538-55114
β-strand560-56232
β-strand574-57632
α-helix586-60722
Chain B: 42 helices, 16 β-strands
ElementResiduesLengthSheet
α-helix22-3110
α-helix37-4812
α-helix60-7617
α-helix110-1123
α-helix116-12813
β-strand131-13333
β-strand141-14333
α-helix144-1474
α-helix149-1535
α-helix158-16912
α-helix173-1764
α-helix177-1793
α-helix181-19313
α-helix199-2035
α-helix204-2074
α-helix230-25122
β-strand26014
β-strand262-26325
α-helix276-2783
α-helix306-31611
β-strand33416
β-strand347-34827
β-strand358-35927
β-strand36216
α-helix367-38216
α-helix399-4068
α-helix409-4124
α-helix424-4263
α-helix435-4428
α-helix443-4475
α-helix450-46415
α-helix473-4808
α-helix481-4855
β-strand487-48825
α-helix499-5024
α-helix504-5074
α-helix514-5207
α-helix523-5297
α-helix530-5323
α-helix549-55810
α-helix568-5747
α-helix582-5876
α-helix589-5924
α-helix594-5963
β-strand60714
α-helix614-6163
β-strand618-62148
α-helix632-6354
α-helix637-65721
α-helix667-6693
β-strand670-67678
β-strand680-68568
β-strand68619
β-strand69419
α-helix697-70610
α-helix708-7114
β-strand72318
α-helix742-76625
Chain D: 43 helices, 17 β-strands
ElementResiduesLengthSheet
α-helix22-3110
α-helix37-4812
α-helix58-603
α-helix64-7613
α-helix91-944
α-helix110-1123
α-helix116-12813
β-strand131-133312
β-strand141-143312
α-helix144-1474
α-helix149-1535
α-helix158-16912
α-helix173-1764
α-helix177-1793
α-helix181-19313
α-helix199-2035
α-helix204-2074
β-strand210113
β-strand216113
α-helix230-25122
β-strand260114
β-strand262-263215
α-helix276-2783
α-helix306-31611
β-strand347-348216
β-strand358-359216
α-helix367-38216
α-helix398-4069
α-helix409-4124
α-helix424-4263
α-helix435-4428
α-helix443-4475
α-helix450-46415
α-helix473-4808
α-helix481-4855
β-strand487-488215
α-helix499-5024
α-helix504-5074
α-helix514-52916
α-helix530-5323
α-helix549-55810
α-helix567-5715
α-helix582-5876
α-helix589-5924
α-helix594-5963
β-strand607114
α-helix614-6163
β-strand618-620317
β-strand621118
α-helix632-6354
α-helix637-65721
α-helix667-6693
β-strand670-676717
β-strand680-685617
β-strand686119
β-strand694119
α-helix697-70610
α-helix708-7114
β-strand723118
α-helix742-76625

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Sodium-dependent neutral amino acid transporter B(0)AT1A, Cprotein654Homo sapiensQ695T7 (AlphaFold model)
Angiotensin-converting enzyme 2B, Dprotein814Homo sapiensQ9BYF1 (AlphaFold model)
Sequence of entity 1 (A, C), FASTA
>6M1D_1 Sodium-dependent neutral amino acid transporter B(0)AT1 (chains A, C)
MADYKDDDDKSGPDEVDASGRVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQ
YMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGS
LGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQT
GYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTG
KAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFS
LAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTN
ILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAF
IVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTG
LICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEF
MIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPN
WVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY
Sequence of entity 2 (B, D), FASTA
>6M1D_2 Angiotensin-converting enzyme 2 (chains B, D)
MRSSSSWLLLSLVAVTAAWSHPQFEKQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYN
TNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSED
KSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSE
VGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFE
EIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNI
DVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDL
GKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLS
AATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKD
QWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQ
AAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPL
FTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAM
RQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRI
NDAFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKK
NKARSGENPYASIDISKGENNPGFQNTDDVQTSF

Primary citation

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Yan, R., Zhang, Y., Li, Y. et al. Science (2020) 367:1444-1448. DOI 10.1126/science.abb2762 · PubMed

Other PDB entries of the same protein (UniProt Q695T7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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