8QR1: Human Tip60 complex
Cryo-EM structure of the human Tip60 complex. Determined by electron microscopy at 2.4 Å resolution. Released 7 Aug 2024.
- Method
- Electron microscopy
- Resolution
- 2.4 Å
- Organism
- Homo sapiens
- Chains
- 13
- Atoms
- 39,353
- Mol. weight
- 966.84 kDa
- Released
- 7 Aug 2024
Explore 8QR1 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8QR1 contains 283 α-helices and 264 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 51 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 778-791 | 14 | |
| α-helix | 795-797 | 3 | |
| α-helix | 798-800 | 3 | |
| β-strand | 801-802 | 2 | 1 |
| α-helix | 803 | 1 | |
| α-helix | 811-899 | 89 | |
| α-helix | 1058-1067 | 10 | |
| α-helix | 1071-1074 | 4 | |
| α-helix | 1082-1084 | 3 | |
| α-helix | 1093-1108 | 16 | |
| α-helix | 1116-1117 | 2 | |
| α-helix | 1122-1132 | 11 | |
| α-helix | 1133-1137 | 5 | |
| β-strand | 1143-1146 | 4 | 2 |
| α-helix | 1149-1151 | 3 | |
| α-helix | 1152-1162 | 11 | |
| β-strand | 1168-1170 | 3 | 2 |
| α-helix | 1175-1184 | 10 | |
| β-strand | 1193-1196 | 4 | 2 |
| α-helix | 1198-1203 | 6 | |
| α-helix | 1205-1209 | 5 | |
| α-helix | 1212-1213 | 2 | |
| β-strand | 1215-1218 | 4 | 2 |
| α-helix | 1229-1237 | 9 | |
| β-strand | 1242-1243 | 2 | 2 |
| α-helix | 1250-1252 | 3 | |
| α-helix | 1255-1265 | 11 | |
| α-helix | 1283-1285 | 3 | |
| α-helix | 1286-1300 | 15 | |
| β-strand | 1321-1326 | 6 | 3 |
| α-helix | 1327-1329 | 3 | |
| α-helix | 1330-1341 | 12 | |
| α-helix | 1343-1351 | 9 | |
| α-helix | 1354-1369 | 16 | |
| α-helix | 1371-1373 | 3 | |
| β-strand | 1381 | 1 | 4 |
| β-strand | 1390-1391 | 2 | 5 |
| α-helix | 1394-1396 | 3 | |
| α-helix | 1404-1406 | 3 | |
| α-helix | 1411-1413 | 3 | |
| α-helix | 1423-1430 | 8 | |
| α-helix | 1752-1757 | 6 | |
| α-helix | 1824-1831 | 8 | |
| α-helix | 1841-1843 | 3 | |
| β-strand | 1845-1846 | 2 | 5 |
| α-helix | 1852-1869 | 18 | |
| α-helix | 1873-1880 | 8 | |
| β-strand | 1885 | 1 | 4 |
| α-helix | 1891-1895 | 5 | |
| α-helix | 1898-1912 | 15 | |
| β-strand | 1917-1921 | 5 | 3 |
| α-helix | 1924-1936 | 13 | |
| β-strand | 1941-1944 | 4 | 3 |
| α-helix | 1950-1962 | 13 | |
| β-strand | 1968-1972 | 5 | 3 |
| α-helix | 1973-1975 | 3 | |
| β-strand | 1987-1990 | 4 | 3 |
| α-helix | 1997-2008 | 12 | |
| β-strand | 2017-2023 | 7 | 3 |
| α-helix | 2027-2033 | 7 | |
| α-helix | 2037-2040 | 4 | |
| α-helix | 2042-2046 | 5 | |
| α-helix | 2048-2050 | 3 | |
| α-helix | 2057-2063 | 7 | |
| α-helix | 2190-2214 | 25 | |
| β-strand | 2222-2224 | 3 | 6 |
| α-helix | 2225-2228 | 4 | |
| β-strand | 2234-2237 | 4 | 7 |
| β-strand | 2240-2244 | 5 | 7 |
| β-strand | 2247-2248 | 2 | 8 |
| α-helix | 2266-2268 | 3 | |
| β-strand | 2270-2274 | 5 | 1 |
Chain B: 19 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-12 | 5 | 15 |
| β-strand | 17-20 | 4 | 15 |
| β-strand | 29-30 | 2 | 15 |
| β-strand | 35 | 1 | 16 |
| β-strand | 54 | 1 | 16 |
| α-helix | 56-60 | 5 | |
| α-helix | 62-64 | 3 | |
| β-strand | 71-72 | 2 | 17 |
| β-strand | 75-76 | 2 | 17 |
| α-helix | 79-88 | 10 | |
| α-helix | 89-93 | 5 | |
| β-strand | 103-104 | 2 | 15 |
| β-strand | 105-107 | 3 | 18 |
| α-helix | 113-125 | 13 | |
| β-strand | 132 | 1 | 19 |
| β-strand | 134-136 | 3 | 18 |
| α-helix | 137-145 | 9 | |
| β-strand | 150-155 | 6 | 20 |
| β-strand | 160-166 | 7 | 20 |
| β-strand | 169-170 | 2 | 20 |
| α-helix | 172-174 | 3 | |
| β-strand | 176-178 | 3 | 20 |
| α-helix | 182-195 | 14 | |
| α-helix | 203-215 | 13 | |
| α-helix | 223-232 | 10 | |
| β-strand | 240-241 | 2 | 21 |
| β-strand | 247-248 | 2 | 21 |
| α-helix | 253-262 | 10 | |
| α-helix | 264-266 | 3 | |
| α-helix | 274-284 | 11 | |
| α-helix | 289-295 | 7 | |
| β-strand | 298 | 1 | 20 |
| α-helix | 309-320 | 12 | |
| β-strand | 330 | 1 | 20 |
| α-helix | 338-347 | 10 | |
| α-helix | 351-353 | 3 | |
| β-strand | 357 | 1 | 19 |
| α-helix | 359-365 | 7 | |
| α-helix | 369-373 | 5 | |
Chain C: 4 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 400-402 | 3 | |
| β-strand | 412-415 | 4 | 1 |
| α-helix | 436-438 | 3 | |
| β-strand | 439-440 | 2 | 9 |
| β-strand | 441-444 | 4 | 8 |
| β-strand | 451-459 | 9 | 8 |
| α-helix | 461-463 | 3 | |
| β-strand | 465-469 | 5 | 8 |
| α-helix | 475-478 | 4 | |
Chain D: 23 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22 | 1 | 63 |
| β-strand | 33 | 1 | 64 |
| α-helix | 38 | 1 | |
| β-strand | 39 | 1 | 64 |
| α-helix | 40 | 1 | |
| β-strand | 42-43 | 2 | 65 |
| β-strand | 46-47 | 2 | 65 |
| α-helix | 50-65 | 16 | |
| β-strand | 68 | 1 | 55 |
| β-strand | 72-77 | 6 | 62 |
| α-helix | 83-94 | 12 | |
| β-strand | 100-104 | 5 | 62 |
| α-helix | 105-108 | 4 | |
| α-helix | 115-125 | 11 | |
| β-strand | 127-148 | 22 | 11 |
| β-strand | 158-164 | 7 | 11 |
| β-strand | 169-174 | 6 | 11 |
| α-helix | 176-185 | 10 | |
| β-strand | 191-196 | 6 | 11 |
| β-strand | 202-207 | 6 | 11 |
| α-helix | 210-212 | 3 | |
| β-strand | 224 | 1 | 11 |
| α-helix | 226-228 | 3 | |
| β-strand | 233-243 | 11 | 11 |
| α-helix | 244-252 | 9 | |
| α-helix | 256-258 | 3 | |
| α-helix | 259-262 | 4 | |
| α-helix | 270-285 | 16 | |
| β-strand | 289-293 | 5 | 11 |
| β-strand | 295-299 | 5 | 62 |
| α-helix | 301-303 | 3 | |
| β-strand | 305 | 1 | 66 |
| α-helix | 306-315 | 10 | |
| β-strand | 323-328 | 6 | 62 |
| β-strand | 332-334 | 3 | 67 |
| α-helix | 335 | 1 | |
| β-strand | 336 | 1 | 66 |
| β-strand | 341-343 | 3 | 67 |
| α-helix | 348-351 | 4 | |
| β-strand | 354-359 | 6 | 62 |
| α-helix | 360-362 | 3 | |
| α-helix | 364-378 | 15 | |
| β-strand | 382 | 1 | 68 |
| α-helix | 384-396 | 13 | |
| α-helix | 399-415 | 17 | |
| β-strand | 421 | 1 | 68 |
| α-helix | 423-432 | 10 | |
| β-strand | 434 | 1 | 69 |
| α-helix | 436-445 | 10 | |
| β-strand | 451 | 1 | 70 |
Chain E: 24 helices, 29 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 13-14 | 2 | |
| β-strand | 15 | 1 | 71 |
| β-strand | 26 | 1 | 72 |
| α-helix | 31 | 1 | |
| β-strand | 32 | 1 | 72 |
| α-helix | 33 | 1 | |
| β-strand | 35-36 | 2 | 73 |
| β-strand | 39-40 | 2 | 73 |
| α-helix | 43-58 | 16 | |
| β-strand | 61 | 1 | 63 |
| β-strand | 65-69 | 5 | 69 |
| α-helix | 76-87 | 12 | |
| β-strand | 93-97 | 5 | 69 |
| α-helix | 98-101 | 4 | |
| α-helix | 108-118 | 11 | |
| β-strand | 120-124 | 5 | 74 |
| β-strand | 127-135 | 9 | 75 |
| β-strand | 139-140 | 2 | 75 |
| β-strand | 144 | 1 | 12 |
| β-strand | 153 | 1 | 12 |
| β-strand | 157-162 | 6 | 75 |
| β-strand | 167-172 | 6 | 75 |
| α-helix | 176-182 | 7 | |
| β-strand | 189-194 | 6 | 75 |
| β-strand | 200-205 | 6 | 75 |
| α-helix | 207-209 | 3 | |
| α-helix | 221-225 | 5 | |
| β-strand | 229-233 | 5 | 75 |
| β-strand | 236-239 | 4 | 74 |
| α-helix | 240-248 | 9 | |
| α-helix | 256-263 | 8 | |
| α-helix | 273-289 | 17 | |
| β-strand | 292-296 | 5 | 74 |
| β-strand | 298-302 | 5 | 69 |
| α-helix | 304-306 | 3 | |
| α-helix | 309-319 | 11 | |
| β-strand | 326-331 | 6 | 69 |
| β-strand | 333 | 1 | 70 |
| β-strand | 335-337 | 3 | 76 |
| α-helix | 338 | 1 | |
| β-strand | 345-347 | 3 | 76 |
| α-helix | 352-355 | 4 | |
| β-strand | 358-362 | 5 | 69 |
| α-helix | 365-367 | 3 | |
| α-helix | 368-381 | 14 | |
| β-strand | 386 | 1 | 77 |
| α-helix | 388-400 | 13 | |
| α-helix | 403-408 | 6 | |
| α-helix | 410-419 | 10 | |
| β-strand | 425 | 1 | 77 |
| α-helix | 427-436 | 10 | |
| β-strand | 438 | 1 | 78 |
| α-helix | 440-449 | 10 | |
Chain F: 14 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 46 | 1 | 7 |
| β-strand | 47-48 | 2 | 8 |
| β-strand | 57-58 | 2 | 9 |
| α-helix | 67-70 | 4 | |
| β-strand | 71 | 1 | 8 |
| β-strand | 72-74 | 3 | 6 |
| α-helix | 81-83 | 3 | |
| α-helix | 84-88 | 5 | |
| α-helix | 92-94 | 3 | |
| β-strand | 95-100 | 6 | 10 |
| β-strand | 111-116 | 6 | 10 |
| α-helix | 117-119 | 3 | |
| α-helix | 122-124 | 3 | |
| α-helix | 125-129 | 5 | |
| α-helix | 140-143 | 4 | |
| α-helix | 154-167 | 14 | |
| α-helix | 171-177 | 7 | |
| α-helix | 180-183 | 4 | |
| α-helix | 190-207 | 18 | |
| α-helix | 220-234 | 15 | |
| α-helix | 238-255 | 18 | |
Chain G: 25 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-12 | 5 | 22 |
| β-strand | 16-21 | 6 | 22 |
| β-strand | 29-32 | 4 | 22 |
| β-strand | 35 | 1 | 23 |
| β-strand | 54 | 1 | 23 |
| α-helix | 56-60 | 5 | |
| β-strand | 68 | 1 | 23 |
| β-strand | 71-72 | 2 | 24 |
| β-strand | 75-76 | 2 | 24 |
| α-helix | 79-88 | 10 | |
| α-helix | 89-94 | 6 | |
| α-helix | 98-100 | 3 | |
| β-strand | 103-107 | 5 | 22 |
| α-helix | 113-121 | 9 | |
| α-helix | 122-126 | 5 | |
| β-strand | 131-136 | 6 | 22 |
| α-helix | 137-144 | 8 | |
| β-strand | 150-155 | 6 | 25 |
| β-strand | 160-166 | 7 | 25 |
| β-strand | 169-170 | 2 | 25 |
| α-helix | 172-174 | 3 | |
| β-strand | 176-178 | 3 | 25 |
| α-helix | 182-196 | 15 | |
| α-helix | 203-216 | 14 | |
| α-helix | 223-232 | 10 | |
| β-strand | 238-241 | 4 | 26 |
| β-strand | 247-250 | 4 | 26 |
| α-helix | 253-256 | 4 | |
| α-helix | 258-261 | 4 | |
| α-helix | 264-267 | 4 | |
| α-helix | 274-283 | 10 | |
| α-helix | 287-289 | 3 | |
| α-helix | 290-295 | 6 | |
| β-strand | 297-300 | 4 | 25 |
| α-helix | 302-305 | 4 | |
| α-helix | 309-320 | 12 | |
| β-strand | 329-330 | 2 | 25 |
| α-helix | 335-337 | 3 | |
| α-helix | 338-348 | 11 | |
| α-helix | 351-355 | 5 | |
| α-helix | 356 | 1 | |
| β-strand | 357-358 | 2 | 22 |
| α-helix | 359-365 | 7 | |
| α-helix | 369-373 | 5 | |
Chain H: 22 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22 | 1 | 45 |
| β-strand | 33 | 1 | 46 |
| α-helix | 38 | 1 | |
| β-strand | 39 | 1 | 46 |
| α-helix | 40 | 1 | |
| β-strand | 42-43 | 2 | 47 |
| β-strand | 46-47 | 2 | 47 |
| α-helix | 50-65 | 16 | |
| β-strand | 68 | 1 | 34 |
| β-strand | 72-77 | 6 | 44 |
| α-helix | 83-94 | 12 | |
| β-strand | 100-104 | 5 | 44 |
| α-helix | 105-108 | 4 | |
| α-helix | 115-125 | 11 | |
| β-strand | 127-142 | 16 | 48 |
| β-strand | 148 | 1 | 49 |
| β-strand | 158 | 1 | 49 |
| β-strand | 164 | 1 | 48 |
| α-helix | 179-182 | 4 | |
| β-strand | 191-196 | 6 | 48 |
| β-strand | 202-204 | 3 | 48 |
| α-helix | 209-212 | 4 | |
| β-strand | 234-243 | 10 | 48 |
| α-helix | 244-251 | 8 | |
| α-helix | 256-258 | 3 | |
| α-helix | 259-262 | 4 | |
| α-helix | 270-286 | 17 | |
| β-strand | 290-293 | 4 | 48 |
| β-strand | 295-299 | 5 | 44 |
| α-helix | 301-303 | 3 | |
| β-strand | 305 | 1 | 50 |
| α-helix | 306-315 | 10 | |
| β-strand | 323-328 | 6 | 44 |
| β-strand | 332-334 | 3 | 51 |
| α-helix | 335 | 1 | |
| β-strand | 336 | 1 | 50 |
| β-strand | 341-343 | 3 | 51 |
| α-helix | 348-351 | 4 | |
| β-strand | 355-359 | 5 | 44 |
| α-helix | 360-362 | 3 | |
| α-helix | 364-377 | 14 | |
| β-strand | 382 | 1 | 52 |
| α-helix | 384-396 | 13 | |
| α-helix | 399-415 | 17 | |
| β-strand | 421 | 1 | 52 |
| α-helix | 423-432 | 10 | |
| β-strand | 434 | 1 | 53 |
| α-helix | 436-445 | 10 | |
| β-strand | 451 | 1 | 54 |
5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| E1A-binding protein p400 | A | protein | 3159 | Homo sapiens | Q96L91 |
| Enhancer of polycomb homolog 1 | C | protein | 836 | Homo sapiens | Q9H2F5 (AlphaFold model) |
| DNA methyltransferase 1-associated protein 1 | F | protein | 467 | Homo sapiens | Q9NPF5 (AlphaFold model) |
| Vacuolar protein sorting-associated protein 72 homolog | S | protein | 364 | Homo sapiens | Q15906 (AlphaFold model) |
| Actin, cytoplasmic 1, N-terminally processed | B, G | protein | 375 | Homo sapiens | P60709 |
| Actin-like protein 6A | K | protein | 429 | Homo sapiens | O96019 |
| RuvB-like 1 | E, I, L | protein | 456 | Homo sapiens | Q9Y265 |
| RuvB-like 2 | D, H, J | protein | 463 | Homo sapiens | Q9Y230 |
Sequence of entity 1 (A), FASTA
>8QR1_1 E1A-binding protein p400 (chains A)
MHHGTGPQNVQHQLQRSRACPGSEGEEQPAHPNPPPSPAAPFAPSASPSAPQSPSYQIQQ
LMNRSPATGQNVNITLQSVGPVVGGNQQITLAPLPLPSPTSPGFQFSAQPRRFEHGSPSY
IQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAPGPGLGLCSSSPTGGFVDASVLVRQI
SLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQ
SPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLGFERTPGV
LLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSLPLTSVGNTGMKKVPKKLEEIPPASPE
MAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQ
NDLDIEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPKVSAAFSSQQQP
FQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQSKRPRLEVGHQGVVFQHPGADAGV
PLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPSTGPPVQNAASLHTPLPQLPGRLPPA
GVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPNVPIPAPPSSQLPIPPSQPAQLALH
VPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPRPLPTSSTSSLAPVSGSGPGPSPAR
SSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSPAQNATSSQDSSQDTLTEQITLENQ
VHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKL
VRTVVRHHEEKQLREERGKKEEQSRLRRIAASTAREIECFWSNIEQVVEIKLRVELEEKR
KKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGRKRKASISLTDDEVDDEEETIEEEE
ANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLPSSQWPRPKPDGEDTSGEEDADDCP
GDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKDIADVTAVAEAILPKGSARVTTSVK
FNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNW
GPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAKRQEWAEPNSFHVCITSYTQ
FFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLELWT
MVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKY
EHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVNVLSILVRLQRICNHPGLVEPRHPG
SSYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLM
EEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQG
PLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTA
QASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVA
QPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTV
SQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAVNALAVGEPGTASKPASPIGGPTQE
EKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICALPSHGRVQWRGSLDGRRGKEAGPA
HSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIPPVVAAPPSLRVPRPPPLYSHRMRI
LRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLIL
SQMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNRDRRIFCAILSTHSRTTGI
NLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGTKDLI
REVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFPVKAEEFVVLSQEPSVTETIAPKIA
RPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSDSENMPCDEEPSQLEELADFMEQLT
PIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAWEFWNLKTLQEREARLRLEQEEAEL
LTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQDDSDIYLDSVMCLMYEATPIPEAKL
PPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGLLKIRREGKEQKKNIL
LKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPN
WDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQL
YTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAE
RIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQPPPPLPQPQAAGSQPPAGPPAVQP
QPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLAGTIKTSVTGTSMPTGAVSGNVIVNTIA
GVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVHTQPPPRAVGSPATATPDLVSMATT
QGVRAVTSVTASAVVTTNLTPVQTPARSLVPQVSQATGVQLPGKTITPAHFQLLRQQQQQ
QQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKM
QKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVA
NLQVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAG
ISVAIGQPQKAAGQTVVAQPVHMQQLLKLKQQAVQQQKAIQPQAAQGPAAVQQKITAQQI
TTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQQVQTQIQVAKLPQVVQQQTPVASI
QQVASASQQASPQTVALTQATAAGQQVQMIPAVTATAQVVQQKLIQQQVVTTASAPLQTP
GAPNPAQVPASSDSPSQQPKLQMRVPAVRLKTPTKPPCQ
Sequence of entity 2 (C), FASTA
>8QR1_2 Enhancer of polycomb homolog 1 (chains C)
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAIS
AQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFKMPKQLIHIQPFSLDAEQPDYDLDSE
DEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIK
KRKNCRGPSLIPSVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRD
LSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYNGEIMSEVMAQRQPMKPTYAIP
IIPITNSSQFKHQEAMDVKEFKVNKQDKADLIRPKRKYEKKPKVLPSSAAATPQQTSPAA
LPVFNAKDLNQYDFPSSDEEPLSQVLSGSSEAEEDNDPDGPFAFRRKAGCQYYAPHLDQT
GNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCIGFARRRVGRGGRVLLDRAHSDYDSVFHH
LDLEMLSSPQHSPVNQFANTSETNTSDKSFSKDLSQILVNIKSCRWRHFRPRTPSLHDSD
NDELSCRKLYRSINRTGTAQPGTQTCSTSTQSKSSSGSAHFAFTAEQYQQHQQQLALMQK
QQLAQIQQQQANSNSSTNTSQNLASNQQKSGFRLNIQGLERTLQGFVSKTLDSASAQFAA
SALVTSEQLMGFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALL
QPSNITQTSSSHSALSHQVTAANSATTQVLIGNNIRLTVPSSVATVNSIAPINARHIPRT
LSAVPSSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIADNTVAMEVT
Sequence of entity 3 (F), FASTA
>8QR1_3 DNA methyltransferase 1-associated protein 1 (chains F)
MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYAL
LYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEE
GKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDH
QQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQ
VAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAE
KPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEEL
VHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGGPATPASGPGPASAE
PAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP
Sequence of entity 4 (S), FASTA
>8QR1_4 Vacuolar protein sorting-associated protein 72 homolog (chains S)
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSD
FDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPL
ELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
ELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPA
PSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPAL
YRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQK
IVIK
Sequence of entity 5 (B, G), FASTA
>8QR1_5 Actin, cytoplasmic 1, N-terminally processed (chains B, G)
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
Sequence of entity 6 (K), FASTA
>8QR1_6 Actin-like protein 6A (chains K)
MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDK
GKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPV
LMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAI
PVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELVPPYMIASKEAVREGSPANWKRK
EKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAE
RLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSF
TDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGG
KQCVERKCP
Sequence of entity 7 (E, I, L), FASTA
>8QR1_7 RuvB-like 1 (chains E, I, L)
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
Sequence of entity 8 (D, H, J), FASTA
>8QR1_8 RuvB-like 2 (chains D, H, J)
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVL
EMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALT
QAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIE
SLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVH
TVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDE
VHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTT
PYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTE
VQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS
Primary citation
Structure of the human TIP60-C histone exchange and acetyltransferase complex. Li, C., Smirnova, E., Schnitzler, C. et al. Nature (2024) 635:764-769. DOI 10.1038/s41586-024-08011-w · PubMed
Other PDB entries of the same protein (UniProt Q96L91), best resolution first:
- 9CAF 2.35 Å, Cryo-EM structure of the reconstituted TRRAP lobe of the human TIP60 complex (composite…
- 9C57 2.75 Å, Reconstituted P400 Subcomplex of the human TIP60 complex
- 9CAD 3.05 Å, Cryo-EM structure of the TRRAP lobe of the native human TIP60 complex (composite…
- 9CAE 3.07 Å, Cryo-EM structure of the reconstituted RuvBL lobe of the human TIP60 complex (composite…
- 8XVT 3.2 Å, The core subcomplex of human NuA4/TIP60 complex
- 8XVV 3.2 Å, The TRRAP module of human NuA4/TIP60 complex
- 9C6N 3.29 Å, ARP module of the human TIP60 complex
- 9C47 3.4 Å, TRRAP module of the human TIP60 complex
- 9CAC 3.43 Å, Cryo-EM structure of the RuvBL lobe of the native human TIP60 complex (composite…
- 8QRI 3.5 Å, TRRAP and EP400 in the human Tip60 complex
- 9C62 5.28 Å, P400 subcomplex of the native human TIP60 complex
- 8XVG 9.4 Å, Structure of human NuA4/TIP60 complex
Browse structure collections
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