8SZH: PDB entry 8SZH

Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs. Determined by electron microscopy at 3.1 Å resolution. Released 7 Feb 2024.

Method

Electron microscopy

Resolution

3.1 Å

Chains

5

Atoms

18,062

Mol. weight

292.06 kDa

Released

7 Feb 2024

Explore 8SZH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8SZH contains 87 α-helices and 110 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 37 helices, 34 β-strands

Chain B: 33 helices, 36 β-strands

Element	Residues	Length	Sheet
β-strand	26-27	2	12
β-strand	32-38	7	12
β-strand	41	1	13
β-strand	44	1	14
β-strand	60	1	14
β-strand	63	1	13
α-helix	65-82	18
β-strand	93-99	7	12
α-helix	104-112	9
α-helix	116-123	8
β-strand	138-142	5	12
α-helix	147-157	11
β-strand	164-166	3	12
α-helix	172-175	4
β-strand	183-185	3	12
α-helix	191-203	13
β-strand	208-214	7	15
α-helix	219-232	14
β-strand	236-243	8	15
α-helix	249-259	11
β-strand	266-270	5	15
α-helix	273-286	14
β-strand	292-295	4	15
α-helix	308-310	3
α-helix	311-314	4
β-strand	318-321	4	15
β-strand	325	1	16
α-helix	330-334	5
β-strand	345	1	12
α-helix	348-356	9
β-strand	359	1	17
β-strand	394	1	17
α-helix	401-403	3
β-strand	414	1	16
α-helix	417-435	19
α-helix	445-447	3
α-helix	452-454	3
α-helix	457-465	9
β-strand	468-470	3	18
β-strand	476-478	3	18
β-strand	489-496	8	15
β-strand	503-511	9	15
β-strand	521-523	3	15
α-helix	525-527	3
β-strand	530	1	19
β-strand	534	1	19
α-helix	544-546	3
β-strand	550-553	4	20
β-strand	564-567	4	20
β-strand	572-573	2	21
β-strand	583-584	2	21
α-helix	585	1
β-strand	589-591	3	22
β-strand	598-600	3	22
β-strand	602-604	3	23
α-helix	611-636	26
α-helix	641-645	5
α-helix	648-663	16
α-helix	664-668	5
α-helix	680-698	19
α-helix	700-703	4
α-helix	725-745	21
β-strand	751-753	3	23
β-strand	760-764	5	23
α-helix	770-792	23
α-helix	803-826	24
α-helix	833-849	17
α-helix	850-854	5
α-helix	855-860	6

Chain C: 10 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	8-30	23
β-strand	34-38	5	24
α-helix	48-52	5
β-strand	186-190	5	24
β-strand	195-199	5	24
α-helix	208-210	3
α-helix	212-215	4
β-strand	220-226	7	24
α-helix	227-230	4
β-strand	234	1	25
β-strand	241	1	25
α-helix	242-254	13
β-strand	263-269	7	24
α-helix	271-278	8
α-helix	283-285	3
α-helix	296-308	13
β-strand	319-323	5	24
α-helix	331-351	21

Chain D: 5 helices, 32 β-strands

Element	Residues	Length	Sheet
α-helix	4-25	22
α-helix	30-34	5
β-strand	47-51	5	26
β-strand	58-61	4	27
β-strand	69	1	28
β-strand	72-74	3	27
β-strand	79-81	3	27
β-strand	83	1	28
β-strand	91-92	2	27
β-strand	100	1	29
β-strand	104-105	2	30
β-strand	111-113	3	30
β-strand	116	1	29
β-strand	121-125	5	30
β-strand	135-139	5	30
β-strand	146-151	6	31
β-strand	157-161	5	31
β-strand	165-168	4	31
β-strand	178-181	4	31
β-strand	187-192	6	32
β-strand	198-203	6	32
β-strand	208-212	5	32
β-strand	218-222	5	32
β-strand	229-234	6	33
β-strand	240-245	6	33
β-strand	250-254	5	33
β-strand	259-264	6	33
α-helix	272	1
β-strand	273-278	6	34
α-helix	279	1
α-helix	280-282	3
β-strand	284-289	6	34
β-strand	294-298	5	34
β-strand	306-308	3	34
β-strand	315-320	6	26
β-strand	327-331	5	26
β-strand	336-339	4	26

Chain E: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	9-23	15
α-helix	30-43	14

Primary citation

Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor. He, F., Wu, C.G., Gao, Y. et al. Nature (2024) 626:1141-1148. DOI 10.1038/s41586-024-07055-2 · PubMed

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