9C6N: ARP module of the human TIP60 complex
ARP module of the human TIP60 complex. Determined by electron microscopy at 3.29 Å resolution. Released 21 Aug 2024.
- Method
- Electron microscopy
- Resolution
- 3.29 Å
- Organism
- Homo sapiens
- Chains
- 5
- Atoms
- 9,076
- Mol. weight
- 580.85 kDa
- Ligands
- ATP
- Released
- 21 Aug 2024
Explore 9C6N in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9C6N contains 71 α-helices and 52 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain G: 6 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 781-790 | 10 | |
| β-strand | 808 | 1 | 1 |
| α-helix | 811-853 | 43 | |
| β-strand | 2222-2224 | 3 | 2 |
| α-helix | 2225-2229 | 5 | |
| β-strand | 2248 | 1 | 2 |
| α-helix | 2249-2251 | 3 | |
| α-helix | 2259 | 1 | |
| β-strand | 2260 | 1 | 1 |
| α-helix | 2261 | 1 | |
Chain H: 0 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 441-445 | 5 | 2 |
| β-strand | 450-459 | 10 | 2 |
| β-strand | 465-469 | 5 | 2 |
Chain I: 13 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 73 | 1 | |
| β-strand | 74-76 | 3 | 2 |
| α-helix | 87-89 | 3 | |
| α-helix | 92-94 | 3 | |
| β-strand | 95-101 | 7 | 3 |
| β-strand | 110-116 | 7 | 3 |
| α-helix | 117-119 | 3 | |
| α-helix | 122-124 | 3 | |
| α-helix | 125-129 | 5 | |
| α-helix | 140-145 | 6 | |
| α-helix | 154-167 | 14 | |
| α-helix | 171-177 | 7 | |
| α-helix | 188-206 | 19 | |
| α-helix | 208-209 | 2 | |
| α-helix | 220-234 | 15 | |
| α-helix | 238-250 | 13 | |
Chain J: 24 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-11 | 4 | 4 |
| β-strand | 16-21 | 6 | 4 |
| β-strand | 29-32 | 4 | 4 |
| β-strand | 35-37 | 3 | 5 |
| β-strand | 53-54 | 2 | 5 |
| α-helix | 56-61 | 6 | |
| β-strand | 66-68 | 3 | 5 |
| β-strand | 71-72 | 2 | 6 |
| β-strand | 75-76 | 2 | 6 |
| α-helix | 79-87 | 9 | |
| α-helix | 88-94 | 7 | |
| α-helix | 98-100 | 3 | |
| β-strand | 103-107 | 5 | 4 |
| α-helix | 113-121 | 9 | |
| α-helix | 122-126 | 5 | |
| β-strand | 131-136 | 6 | 4 |
| α-helix | 137-145 | 9 | |
| β-strand | 150-155 | 6 | 7 |
| β-strand | 160-166 | 7 | 7 |
| β-strand | 169-170 | 2 | 7 |
| α-helix | 172-174 | 3 | |
| β-strand | 176-178 | 3 | 7 |
| α-helix | 182-196 | 15 | |
| α-helix | 203-216 | 14 | |
| α-helix | 223-232 | 10 | |
| β-strand | 238-241 | 4 | 8 |
| β-strand | 247-250 | 4 | 8 |
| α-helix | 253-256 | 4 | |
| α-helix | 258-262 | 5 | |
| α-helix | 264-267 | 4 | |
| α-helix | 274-284 | 11 | |
| α-helix | 290-295 | 6 | |
| β-strand | 297-300 | 4 | 7 |
| α-helix | 302-305 | 4 | |
| α-helix | 309-320 | 12 | |
| β-strand | 329-330 | 2 | 7 |
| α-helix | 335-337 | 3 | |
| α-helix | 338-348 | 11 | |
| α-helix | 351-355 | 5 | |
| α-helix | 356 | 1 | |
| β-strand | 357-358 | 2 | 4 |
| α-helix | 359-365 | 7 | |
| α-helix | 368-373 | 6 | |
Chain L: 28 helices, 23 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 14-18 | 5 | 9 |
| β-strand | 22-27 | 6 | 9 |
| β-strand | 35-38 | 4 | 9 |
| β-strand | 41-44 | 4 | 10 |
| β-strand | 67-69 | 3 | 10 |
| α-helix | 72-76 | 5 | |
| β-strand | 83-85 | 3 | 10 |
| β-strand | 88-89 | 2 | 11 |
| β-strand | 92-93 | 2 | 11 |
| α-helix | 96-105 | 10 | |
| α-helix | 106-111 | 6 | |
| α-helix | 115-117 | 3 | |
| β-strand | 120-124 | 5 | 9 |
| α-helix | 130-139 | 10 | |
| α-helix | 140-144 | 5 | |
| β-strand | 148-153 | 6 | 9 |
| α-helix | 154-162 | 9 | |
| β-strand | 167-172 | 6 | 12 |
| β-strand | 177-183 | 7 | 12 |
| β-strand | 186-187 | 2 | 12 |
| α-helix | 189-191 | 3 | |
| β-strand | 193-195 | 3 | 12 |
| α-helix | 199-213 | 15 | |
| α-helix | 215-217 | 3 | |
| α-helix | 220-222 | 3 | |
| β-strand | 223-226 | 4 | 13 |
| α-helix | 234-235 | 2 | |
| β-strand | 237-239 | 3 | 13 |
| α-helix | 243-245 | 3 | |
| α-helix | 248-266 | 19 | |
| β-strand | 268 | 1 | 14 |
| α-helix | 276-280 | 5 | |
| β-strand | 285-288 | 4 | 15 |
| β-strand | 294-297 | 4 | 15 |
| α-helix | 300-303 | 4 | |
| α-helix | 305-308 | 4 | |
| α-helix | 311-313 | 3 | |
| α-helix | 325-334 | 10 | |
| α-helix | 338-340 | 3 | |
| α-helix | 341-345 | 5 | |
| β-strand | 348-351 | 4 | 12 |
| α-helix | 353-356 | 4 | |
| β-strand | 358 | 1 | 14 |
| α-helix | 360-371 | 12 | |
| β-strand | 380 | 1 | 12 |
| α-helix | 386-390 | 5 | |
| α-helix | 392-402 | 11 | |
| α-helix | 405-409 | 5 | |
| α-helix | 410 | 1 | |
| β-strand | 411-412 | 2 | 9 |
| α-helix | 413-427 | 15 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| E1A-binding protein p400 | G | protein | 3159 | Homo sapiens | Q96L91 |
| Enhancer of polycomb homolog 1 | H | protein | 836 | Homo sapiens | Q9H2F5 (AlphaFold model) |
| DNA methyltransferase 1-associated protein 1 | I | protein | 467 | Homo sapiens | Q9NPF5 (AlphaFold model) |
| Actin, cytoplasmic 1 | J | protein | 375 | Homo sapiens | P60709 (AlphaFold model) |
| Actin-like protein 6A | L | protein | 429 | Homo sapiens | O96019 |
Sequence of entity 1 (G), FASTA
>9C6N_1 E1A-binding protein p400 (chains G)
MHHGTGPQNVQHQLQRSRACPGSEGEEQPAHPNPPPSPAAPFAPSASPSAPQSPSYQIQQ
LMNRSPATGQNVNITLQSVGPVVGGNQQITLAPLPLPSPTSPGFQFSAQPRRFEHGSPSY
IQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAPGPGLGLCSSSPTGGFVDASVLVRQI
SLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQ
SPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLGFERTPGV
LLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSLPLTSVGNTGMKKVPKKLEEIPPASPE
MAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQ
NDLDIEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPKVSAAFSSQQQP
FQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQSKRPRLEVGHQGVVFQHPGADAGV
PLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPSTGPPVQNAASLHTPLPQLPGRLPPA
GVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPNVPIPAPPSSQLPIPPSQPAQLALH
VPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPRPLPTSSTSSLAPVSGSGPGPSPAR
SSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSPAQNATSSQDSSQDTLTEQITLENQ
VHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKL
VRTVVRHHEEKQLREERGKKEEQSRLRRIAASTAREIECFWSNIEQVVEIKLRVELEEKR
KKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGRKRKASISLTDDEVDDEEETIEEEE
ANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLPSSQWPRPKPDGEDTSGEEDADDCP
GDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKDIADVTAVAEAILPKGSARVTTSVK
FNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNW
GPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAKRQEWAEPNSFHVCITSYTQ
FFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLELWT
MVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKY
EHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVNVLSILVRLQRICNHPGLVEPRHPG
SSYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLM
EEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQG
PLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTA
QASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVA
QPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTV
SQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAVNALAVGEPGTASKPASPIGGPTQE
EKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICALPSHGRVQWRGSLDGRRGKEAGPA
HSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIPPVVAAPPSLRVPRPPPLYSHRMRI
LRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLIL
SQMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNRDRRIFCAILSTHSRTTGI
NLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGTKDLI
REVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFPVKAEEFVVLSQEPSVTETIAPKIA
RPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSDSENMPCDEEPSQLEELADFMEQLT
PIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAWEFWNLKTLQEREARLRLEQEEAEL
LTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQDDSDIYLDSVMCLMYEATPIPEAKL
PPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGLLKIRREGKEQKKNIL
LKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPN
WDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQL
YTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAE
RIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQPPPPLPQPQAAGSQPPAGPPAVQP
QPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLAGTIKTSVTGTSMPTGAVSGNVIVNTIA
GVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVHTQPPPRAVGSPATATPDLVSMATT
QGVRAVTSVTASAVVTTNLTPVQTPARSLVPQVSQATGVQLPGKTITPAHFQLLRQQQQQ
QQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKM
QKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVA
NLQVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAG
ISVAIGQPQKAAGQTVVAQPVHMQQLLKLKQQAVQQQKAIQPQAAQGPAAVQQKITAQQI
TTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQQVQTQIQVAKLPQVVQQQTPVASI
QQVASASQQASPQTVALTQATAAGQQVQMIPAVTATAQVVQQKLIQQQVVTTASAPLQTP
GAPNPAQVPASSDSPSQQPKLQMRVPAVRLKTPTKPPCQ
Sequence of entity 2 (H), FASTA
>9C6N_2 Enhancer of polycomb homolog 1 (chains H)
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAIS
AQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFKMPKQLIHIQPFSLDAEQPDYDLDSE
DEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIK
KRKNCRGPSLIPSVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRD
LSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYNGEIMSEVMAQRQPMKPTYAIP
IIPITNSSQFKHQEAMDVKEFKVNKQDKADLIRPKRKYEKKPKVLPSSAAATPQQTSPAA
LPVFNAKDLNQYDFPSSDEEPLSQVLSGSSEAEEDNDPDGPFAFRRKAGCQYYAPHLDQT
GNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCIGFARRRVGRGGRVLLDRAHSDYDSVFHH
LDLEMLSSPQHSPVNQFANTSETNTSDKSFSKDLSQILVNIKSCRWRHFRPRTPSLHDSD
NDELSCRKLYRSINRTGTAQPGTQTCSTSTQSKSSSGSAHFAFTAEQYQQHQQQLALMQK
QQLAQIQQQQANSNSSTNTSQNLASNQQKSGFRLNIQGLERTLQGFVSKTLDSASAQFAA
SALVTSEQLMGFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALL
QPSNITQTSSSHSALSHQVTAANSATTQVLIGNNIRLTVPSSVATVNSIAPINARHIPRT
LSAVPSSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIADNTVAMEVT
Sequence of entity 3 (I), FASTA
>9C6N_3 DNA methyltransferase 1-associated protein 1 (chains I)
MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYAL
LYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEE
GKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDH
QQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQ
VAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAE
KPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEEL
VHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGGPATPASGPGPASAE
PAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP
Sequence of entity 4 (J), FASTA
>9C6N_4 Actin, cytoplasmic 1 (chains J)
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
Sequence of entity 5 (L), FASTA
>9C6N_5 Actin-like protein 6A (chains L)
MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDK
GKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPV
LMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAI
PVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELVPPYMIASKEAVREGSPANWKRK
EKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAE
RLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSF
TDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGG
KQCVERKCP
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 2 |
Primary citation
Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Yang, Z., Mameri, A., Cattoglio, C. et al. Science (2024) 385:eadl5816-eadl5816. DOI 10.1126/science.adl5816 · PubMed
Other PDB entries of the same protein (UniProt Q96L91), best resolution first:
- 9CAF 2.35 Å, Cryo-EM structure of the reconstituted TRRAP lobe of the human TIP60 complex (composite…
- 8QR1 2.4 Å, Cryo-EM structure of the human Tip60 complex
- 9C57 2.75 Å, Reconstituted P400 Subcomplex of the human TIP60 complex
- 9CAD 3.05 Å, Cryo-EM structure of the TRRAP lobe of the native human TIP60 complex (composite…
- 9CAE 3.07 Å, Cryo-EM structure of the reconstituted RuvBL lobe of the human TIP60 complex (composite…
- 8XVT 3.2 Å, The core subcomplex of human NuA4/TIP60 complex
- 8XVV 3.2 Å, The TRRAP module of human NuA4/TIP60 complex
- 9C47 3.4 Å, TRRAP module of the human TIP60 complex
- 9CAC 3.43 Å, Cryo-EM structure of the RuvBL lobe of the native human TIP60 complex (composite…
- 8QRI 3.5 Å, TRRAP and EP400 in the human Tip60 complex
- 9C62 5.28 Å, P400 subcomplex of the native human TIP60 complex
- 8XVG 9.4 Å, Structure of human NuA4/TIP60 complex
Browse structure collections
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